CRCGN017_MCF10A.TP53.M_24H:G23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4-(methylnitrosamino)-1-(3-pyri?dyl)-1-butanol 32.71 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

50 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:G23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SSBP2 single-stranded DNA binding protein 2 5.71604
CNRIP1 cannabinoid receptor interacting protein 1 4.82949
IGHMBP2 immunoglobulin mu binding protein 2 3.45564
DHDDS dehydrodolichyl diphosphate synthase 2.77843
ITFG1 integrin alpha FG-GAP repeat containing 1 2.59857
FOXC1 forkhead box C1 2.4361
POMT1 protein-O-mannosyltransferase 1 2.43377
LOC122526780 uncharacterized LOC122526780 2.40639
NDUFA10 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa 2.37267
ZXDC ZXD family zinc finger C 2.36289
DENND2D DENN/MADD domain containing 2D 2.31211
RINT1 RAD50 interactor 1 2.30293
ZMIZ1 zinc finger, MIZ-type containing 1 2.30275
BBS1 Bardet-Biedl syndrome 1 2.25781
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 2.24571
NPPB natriuretic peptide B 2.19707
NT5DC3 5'-nucleotidase domain containing 3 2.15438
AFF4 AF4/FMR2 family, member 4 2.1452
PDE5A phosphodiesterase 5A, cGMP-specific 2.11513
CER1 cerberus 1, DAN family BMP antagonist 2.0935
UTRN utrophin 2.09003
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa 2.03736
HAPSTR1 HUWE1 associated protein modifying stress responses 2.02107
TMEM101 transmembrane protein 101 2.01811
MEFV Mediterranean fever 2.01564
DDB1 damage-specific DNA binding protein 1, 127kDa 2.01161
DCLK1 doublecortin-like kinase 1 2.00832

decreased expression

Symbol Name Standardized Value
TNIP1 TNFAIP3 interacting protein 1 -5.47246
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -3.36541
EXOSC4 exosome component 4 -3.27043
TMEM115 transmembrane protein 115 -3.14838
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.07938
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.82407
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) -2.60776
APEH acylaminoacyl-peptide hydrolase -2.56653
IFRD2 interferon-related developmental regulator 2 -2.52581
CYB561D2 cytochrome b561 family, member D2 -2.48447
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.42385
SORBS3 sorbin and SH3 domain containing 3 -2.38474
SFMBT1 Scm-like with four mbt domains 1 -2.37659
TEX264 testis expressed 264 -2.37113
FBXO7 F-box protein 7 -2.22993
ACY1 aminoacylase 1 -2.14056
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa -2.13651
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae) -2.08339
TICAM1 toll-like receptor adaptor molecule 1 -2.08142
QARS1 glutaminyl-tRNA synthetase 1 -2.0548
MSN moesin -2.0233
POLR2H polymerase (RNA) II (DNA directed) polypeptide H -2.02224
PPIE peptidylprolyl isomerase E (cyclophilin E) -2.00062