| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 4-(methylnitrosamino)-1-(3-pyri?dyl)-1-butanol 10.9 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome) |
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69 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:G24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PPARG | peroxisome proliferator-activated receptor gamma | 10.0 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | 4.75925 |
| CCDC92 | coiled-coil domain containing 92 | 4.70635 |
| RPL39L | ribosomal protein L39-like | 4.49585 |
| SPAG4 | sperm associated antigen 4 | 4.45535 |
| LGMN | legumain | 4.20255 |
| STK10 | serine/threonine kinase 10 | 4.13767 |
| UGDH | UDP-glucose 6-dehydrogenase | 4.03625 |
| ABHD4 | abhydrolase domain containing 4 | 3.932 |
| TIMM22 | translocase of inner mitochondrial membrane 22 homolog (yeast) | 3.8912 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 3.05159 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 3.0365 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 3.01 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 2.76263 |
| MMP1 | matrix metallopeptidase 1 | 2.74055 |
| CORO1A | coronin, actin binding protein, 1A | 2.60025 |
| SLC16A7 | solute carrier family 16 (monocarboxylate transporter), member 7 | 2.3348 |
| FPGS | folylpolyglutamate synthase | 2.3066 |
| LPL | lipoprotein lipase | 2.3018 |
| CXCL13 | chemokine (C-X-C motif) ligand 13 | 2.2724 |
| EMC8 | ER membrane protein complex subunit 8 | 2.16895 |
| DNM2 | dynamin 2 | 2.1558 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 2.14875 |
| UEVLD | UEV and lactate/malate dehyrogenase domains | 2.1325 |
| LOC128031832 | uncharacterized LOC128031832 | 2.13245 |
| UPK3B | uroplakin 3B | 2.05865 |
| ADRB2 | adrenoceptor beta 2, surface | 2.0572 |
| BMP5 | bone morphogenetic protein 5 | 2.04838 |
| LRP5 | low density lipoprotein receptor-related protein 5 | 2.0426 |
| NR1H3 | nuclear receptor subfamily 1, group H, member 3 | 2.02005 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MSMO1 | methylsterol monooxygenase 1 | -5.0 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -4.699 |
| PPIC | peptidylprolyl isomerase C (cyclophilin C) | -4.38688 |
| NUSAP1 | nucleolar and spindle associated protein 1 | -3.70255 |
| CLTB | clathrin, light chain B | -3.41943 |
| GGCT | gamma-glutamylcyclotransferase | -3.1424 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -2.8518 |
| DSG1 | desmoglein 1 | -2.7809 |
| KRT2 | keratin 2, type II | -2.67145 |
| PAIP1 | poly(A) binding protein interacting protein 1 | -2.66305 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -2.64865 |
| CYP4F2 | cytochrome P450, family 4, subfamily F, polypeptide 2 | -2.49128 |
| LORICRIN | loricrin cornified envelope precursor protein | -2.4458 |
| KBTBD2 | kelch repeat and BTB (POZ) domain containing 2 | -2.42915 |
| PARG | poly (ADP-ribose) glycohydrolase | -2.3622 |
| FOXRED2 | FAD-dependent oxidoreductase domain containing 2 | -2.34095 |
| AHNAK2 | AHNAK nucleoprotein 2 | -2.28105 |
| PTPRZ1 | protein tyrosine phosphatase, receptor-type, Z polypeptide 1 | -2.2054 |
| EGR3 | early growth response 3 | -2.18605 |
| REG1A | regenerating islet-derived 1 alpha | -2.1758 |
| SLC5A1 | solute carrier family 5 (sodium/glucose cotransporter), member 1 | -2.1703 |
| JMJD1C | jumonji domain containing 1C | -2.12245 |
| ATP5PF | ATP synthase peripheral stalk subunit F6 | -2.12225 |
| TGM5 | transglutaminase 5 | -2.1118 |
| KDM3A | lysine (K)-specific demethylase 3A | -2.1089 |
| PDZK1IP1 | PDZK1 interacting protein 1 | -2.0943 |
| KLK8 | kallikrein-related peptidase 8 | -2.0829 |
| SERPINB4 | serpin peptidase inhibitor, clade B (ovalbumin), member 4 | -2.0623 |
| SETBP1 | SET binding protein 1 | -2.0578 |
| PLK2 | polo-like kinase 2 | -2.0463 |
| STEAP1B | STEAP family member 1B | -2.04465 |
| CBX3 | chromobox homolog 3 | -2.03708 |
| UBXN2B | UBX domain protein 2B | -2.0319 |
| TRIP4 | thyroid hormone receptor interactor 4 | -2.02465 |
| ABCG5 | ATP-binding cassette, sub-family G (WHITE), member 5 | -2.0186 |
| EPHX3 | epoxide hydrolase 3 | -2.0157 |
| CBX1 | chromobox homolog 1 | -2.013 |
| ENDOU | endonuclease, polyU-specific | -2.0116 |
| CASP1 | caspase 1, apoptosis-related cysteine peptidase | -2.00212 |
