CRCGN017_MCF10A.TP53.M_24H:H01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-nitrosopiperidine 100.46 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

62 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:H01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
FKBP14 FK506 binding protein 14, 22 kDa 4.7883
ADO 2-aminoethanethiol (cysteamine) dioxygenase 4.55293
KIF5C kinesin family member 5C 4.27943
TXNL4B thioredoxin-like 4B 4.2303
ACLY ATP citrate lyase 4.20957
LOC122526780 uncharacterized LOC122526780 4.031
MICALL1 MICAL-like 1 3.62617
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.57475
GPER1 G protein-coupled estrogen receptor 1 3.5601
FGFR4 fibroblast growth factor receptor 4 3.1106
TBC1D31 TBC1 domain family, member 31 2.97245
NUCB2 nucleobindin 2 2.8836
ACAA1 acetyl-CoA acyltransferase 1 2.87915
TBX2 T-box 2 2.84075
TBPL1 TBP-like 1 2.50485
INTS6 integrator complex subunit 6 2.47447
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14 2.45175
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.38828
GPHRA golgi pH regulator A 2.38777
TMEM51 transmembrane protein 51 2.38045
DMXL1 Dmx-like 1 2.3761
SMTN smoothelin 2.35635
SNCA synuclein, alpha (non A4 component of amyloid precursor) 2.34983
RECQL RecQ helicase-like 2.3451
HBA1 hemoglobin, alpha 1 2.32375
KLK11 kallikrein-related peptidase 11 2.3112
CIC capicua transcriptional repressor 2.16155
MRM2 mitochondrial rRNA methyltransferase 2 2.13835
PRR16 proline rich 16 2.0958
FLNA filamin A, alpha 2.05558
TRAPPC11 trafficking protein particle complex 11 2.0218
FIP1L1 factor interacting with PAPOLA and CPSF1 2.0089

decreased expression

Symbol Name Standardized Value
RPIA ribose 5-phosphate isomerase A -4.1737
CIAPIN1 cytokine induced apoptosis inhibitor 1 -3.38205
CAB39 calcium binding protein 39 -3.1678
CD81 CD81 molecule -3.1654
CANT1 calcium activated nucleotidase 1 -2.9336
KDM3A lysine (K)-specific demethylase 3A -2.79035
TMEM9B TMEM9 domain family, member B -2.3866
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 -2.37765
GPA33 glycoprotein A33 (transmembrane) -2.349
OTC ornithine carbamoyltransferase -2.2962
CDKL2 cyclin-dependent kinase-like 2 (CDC2-related kinase) -2.2728
TPGS2 tubulin polyglutamylase complex subunit 2 -2.20807
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.1814
TFCP2L1 transcription factor CP2-like 1 -2.16705
FAM222B family with sequence similarity 222, member B -2.1648
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) -2.1629
CXCL14 chemokine (C-X-C motif) ligand 14 -2.1566
MARCHF3 membrane associated ring-CH-type finger 3 -2.141
OR7A5 olfactory receptor, family 7, subfamily A, member 5 -2.1379
SIGLEC5 sialic acid binding Ig-like lectin 5 -2.135
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 -2.1234
WNT2 wingless-type MMTV integration site family member 2 -2.09885
GREB1L growth regulation by estrogen in breast cancer-like -2.0802
CCNK cyclin K -2.06175
TTPA tocopherol (alpha) transfer protein -2.0474
ACSL6 acyl-CoA synthetase long-chain family member 6 -2.04357
CDX1 caudal type homeobox 1 -2.028
PEAK1 pseudopodium-enriched atypical kinase 1 -2.00545
TCEAL4 transcription elongation factor A (SII)-like 4 -2.0052
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G -2.00485