CRCGN017_MCF10A.TP53.M_24H:H02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-nitrosopiperidine 33.49 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

42 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:H02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CASP2 caspase 2, apoptosis-related cysteine peptidase 5.05636
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 4.83315
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 4.57955
MAST2 microtubule associated serine/threonine kinase 2 3.83012
DHRS2 dehydrogenase/reductase (SDR family) member 2 3.33865
NUTF2 nuclear transport factor 2 3.0338
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 2.73875
ACAA1 acetyl-CoA acyltransferase 1 2.7018
GRB10 growth factor receptor-bound protein 10 2.53293
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 2.39275
LGMN legumain 2.2237
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 2.22345
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 2.17055
MTA2 metastasis associated 1 family, member 2 2.0556
OSTF1 osteoclast stimulating factor 1 2.02255

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -5.0
COG2 component of oligomeric golgi complex 2 -4.92885
BASP1 brain abundant, membrane attached signal protein 1 -3.97715
GDF15 growth differentiation factor 15 -3.61335
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.16745
DZANK1 double zinc ribbon and ankyrin repeat domains 1 -2.9423
TRIB3 tribbles pseudokinase 3 -2.83695
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -2.44953
EXOSC4 exosome component 4 -2.43
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) -2.37235
IGFBP7 insulin-like growth factor binding protein 7 -2.3219
ZNF250 zinc finger protein 250 -2.26105
NSFL1C NSFL1 (p97) cofactor (p47) -2.25398
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa -2.2509
PANK2 pantothenate kinase 2 -2.2425
ZNF34 zinc finger protein 34 -2.23485
PBLD phenazine biosynthesis-like protein domain containing -2.2228
ZNF133 zinc finger protein 133 -2.21028
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -2.20442
CIB1 calcium and integrin binding 1 (calmyrin) -2.191
CRNKL1 crooked neck pre-mRNA splicing factor 1 -2.1233
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2) -2.09035
SEC23B Sec23 homolog B (S. cerevisiae) -2.07225
PLAAT3 phospholipase A and acyltransferase 3 -2.05585
CRYZL1 crystallin, zeta (quinone reductase)-like 1 -2.0457
NEK11 NIMA-related kinase 11 -2.01625
MTX1 metaxin 1 -2.012