| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | tetracycline 33.82 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome) |
| Similar Terms | |
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158 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:H11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 8.15543 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 7.05997 |
| PYCR1 | pyrroline-5-carboxylate reductase 1 | 6.91588 |
| TRIB3 | tribbles pseudokinase 3 | 5.67284 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | 5.64641 |
| AARS1 | alanyl-tRNA synthetase 1 | 5.59968 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | 5.54884 |
| PSAT1 | phosphoserine aminotransferase 1 | 5.42289 |
| PHGDH | phosphoglycerate dehydrogenase | 5.28121 |
| GARS1 | glycyl-tRNA synthetase 1 | 5.20685 |
| SLC1A4 | solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 | 5.19897 |
| ATF4 | activating transcription factor 4 | 4.83945 |
| SHMT2 | serine hydroxymethyltransferase 2 (mitochondrial) | 4.66429 |
| XPOT | exportin, tRNA | 4.46425 |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 | 4.21078 |
| GLRX | glutaredoxin (thioltransferase) | 3.95833 |
| KLHL21 | kelch-like family member 21 | 3.79477 |
| SLC3A2 | solute carrier family 3 (amino acid transporter heavy chain), member 2 | 3.76176 |
| SLC1A5 | solute carrier family 1 (neutral amino acid transporter), member 5 | 3.75472 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | 3.71989 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 3.68295 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 3.67215 |
| LOC128125814 | uncharacterized LOC128125814 | 3.67177 |
| TXNRD1 | thioredoxin reductase 1 | 3.66838 |
| HAX1 | HCLS1 associated protein X-1 | 3.60718 |
| VSIG2 | V-set and immunoglobulin domain containing 2 | 3.59246 |
| MARS1 | methionyl-tRNA synthetase 1 | 3.53663 |
| CARS1 | cysteinyl-tRNA synthetase 1 | 3.46012 |
| TARS1 | threonyl-tRNA synthetase 1 | 3.45686 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 3.39074 |
| NUCB2 | nucleobindin 2 | 3.37575 |
| AGR2 | anterior gradient 2 | 3.35552 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 3.3301 |
| CXCR4 | chemokine (C-X-C motif) receptor 4 | 3.29438 |
| IFRD1 | interferon-related developmental regulator 1 | 3.15529 |
| ZCCHC8 | zinc finger, CCHC domain containing 8 | 3.14005 |
| SARS1 | seryl-tRNA synthetase 1 | 3.06088 |
| GRB10 | growth factor receptor-bound protein 10 | 3.01042 |
| CEBPG | CCAAT/enhancer binding protein (C/EBP), gamma | 3.0039 |
| EGR1 | early growth response 1 | 2.98911 |
| CTSL | cathepsin L | 2.97538 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 2.95026 |
| YARS1 | tyrosyl-tRNA synthetase 1 | 2.93759 |
| EGR3 | early growth response 3 | 2.75072 |
| RBKS | ribokinase | 2.69052 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | 2.66895 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 2.66311 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | 2.66056 |
| RBP4 | retinol binding protein 4, plasma | 2.64007 |
| AGL | amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase | 2.56603 |
| NARS1 | asparaginyl-tRNA synthetase 1 | 2.56033 |
| TES | testin LIM domain protein | 2.54457 |
| DECR1 | 2,4-dienoyl CoA reductase 1, mitochondrial | 2.52873 |
| HMOX1 | heme oxygenase 1 | 2.52332 |
| SMIM40 | small integral membrane protein 40 | 2.49363 |
| NLRP4 | NLR family, pyrin domain containing 4 | 2.47255 |
| YIF1A | Yip1 interacting factor homolog A (S. cerevisiae) | 2.47194 |
| CNIH1 | cornichon family AMPA receptor auxiliary protein 1 | 2.44982 |
| LYPLA1-TCEA1 | LYPLA1-TCEA1 readthrough | 2.42276 |
| DDIT4 | DNA-damage-inducible transcript 4 | 2.41684 |
| ECH1 | enoyl CoA hydratase 1, peroxisomal | 2.394 |
| CHMP4B | charged multivesicular body protein 4B | 2.38086 |
| CCDC85B | coiled-coil domain containing 85B | 2.3318 |
| MRPS16 | mitochondrial ribosomal protein S16 | 2.29686 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 2.29168 |
| SLC43A1 | solute carrier family 43 (amino acid system L transporter), member 1 | 2.22687 |
| SLC25A13 | solute carrier family 25 (aspartate/glutamate carrier), member 13 | 2.20616 |
| MID1IP1 | MID1 interacting protein 1 | 2.19923 |
| P3H1 | prolyl 3-hydroxylase 1 | 2.1859 |
| POLD4 | polymerase (DNA-directed), delta 4, accessory subunit | 2.12797 |
| GOLT1A | golgi transport 1A | 2.09026 |
| CCNA1 | cyclin A1 | 2.05837 |
| SLC31A1 | solute carrier family 31 (copper transporter), member 1 | 2.03574 |
| PIGP | phosphatidylinositol glycan anchor biosynthesis, class P | 2.02729 |
| Symbol | Name | Standardized Value |
|---|---|---|
| BAG3 | BCL2-associated athanogene 3 | -4.75356 |
| HSPB1 | heat shock 27kDa protein 1 | -4.482 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -4.25638 |
| S100A4 | S100 calcium binding protein A4 | -4.16442 |
| ANXA2 | annexin A2 | -3.69839 |
| GRWD1 | glutamate-rich WD repeat containing 1 | -3.56081 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -3.50465 |
| TRAPPC3 | trafficking protein particle complex 3 | -3.44745 |
| MSMO1 | methylsterol monooxygenase 1 | -3.43812 |
| PRR15L | proline rich 15-like | -3.31628 |
| INSIG1 | insulin induced gene 1 | -3.28239 |
| ANKRD10 | ankyrin repeat domain 10 | -3.2116 |
| C2CD5 | C2 calcium-dependent domain containing 5 | -3.10878 |
| STMN1 | stathmin 1 | -3.06281 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -3.05856 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -3.02834 |
| NSDHL | NAD(P) dependent steroid dehydrogenase-like | -3.02063 |
| ALDOC | aldolase C, fructose-bisphosphate | -2.99892 |
| HOXA4 | homeobox A4 | -2.77331 |
| NDUFS3 | NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) | -2.77014 |
| TCEA2 | transcription elongation factor A (SII), 2 | -2.70626 |
| HOXA5 | homeobox A5 | -2.61298 |
| SH3D19 | SH3 domain containing 19 | -2.60873 |
| SNCG | synuclein, gamma (breast cancer-specific protein 1) | -2.60211 |
| SLC34A2 | solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 | -2.59568 |
| SQOR | sulfide quinone oxidoreductase | -2.57765 |
| SYTL3 | synaptotagmin-like 3 | -2.52752 |
| PYDC1 | PYD (pyrin domain) containing 1 | -2.52135 |
| SLC2A6 | solute carrier family 2 (facilitated glucose transporter), member 6 | -2.52053 |
| ELOVL6 | ELOVL fatty acid elongase 6 | -2.49979 |
| ZNF557 | zinc finger protein 557 | -2.45277 |
| CIAPIN1 | cytokine induced apoptosis inhibitor 1 | -2.40375 |
| TICAM1 | toll-like receptor adaptor molecule 1 | -2.3663 |
| RRAGB | Ras-related GTP binding B | -2.34752 |
| SMNDC1 | survival motor neuron domain containing 1 | -2.34198 |
| ARFIP2 | ADP-ribosylation factor interacting protein 2 | -2.32681 |
| RGS2 | regulator of G-protein signaling 2 | -2.3266 |
| CLN3 | ceroid-lipofuscinosis, neuronal 3 | -2.31275 |
| ELAC2 | elaC ribonuclease Z 2 | -2.31183 |
| USB1 | U6 snRNA biogenesis 1 | -2.29824 |
| STAP2 | signal transducing adaptor family member 2 | -2.28843 |
| XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | -2.27302 |
| ZFP91 | ZFP91 zinc finger protein | -2.26203 |
| RIT2 | Ras-like without CAAX 2 | -2.25809 |
| STEAP4 | STEAP family member 4 | -2.25764 |
| SFTPD | surfactant protein D | -2.2419 |
| EPB41L5 | erythrocyte membrane protein band 4.1 like 5 | -2.23398 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | -2.23295 |
| MAB21L1 | mab-21-like 1 (C. elegans) | -2.23265 |
| CAPN1 | calpain 1, (mu/I) large subunit | -2.23022 |
| SPINK5 | serine peptidase inhibitor, Kazal type 5 | -2.21463 |
| SERF1A | small EDRK-rich factor 1A (telomeric) | -2.20537 |
| MED31 | mediator complex subunit 31 | -2.20513 |
| CACNA2D2 | calcium channel, voltage-dependent, alpha 2/delta subunit 2 | -2.20391 |
| DHCR24 | 24-dehydrocholesterol reductase | -2.20199 |
| LOC100652777 | group 10 secretory phospholipase A2-like | -2.18582 |
| IAPP | islet amyloid polypeptide | -2.17707 |
| PEX26 | peroxisomal biogenesis factor 26 | -2.16621 |
| UQCR10 | ubiquinol-cytochrome c reductase, complex III subunit X | -2.15332 |
| CLCN2 | chloride channel, voltage-sensitive 2 | -2.14598 |
| GPR39 | G protein-coupled receptor 39 | -2.12563 |
| GINS3 | GINS complex subunit 3 (Psf3 homolog) | -2.12424 |
| LRIG2 | leucine-rich repeats and immunoglobulin-like domains 2 | -2.11884 |
| MVP | major vault protein | -2.10625 |
| GRIA4 | glutamate receptor, ionotropic, AMPA 4 | -2.10003 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -2.09895 |
| UBE2W | ubiquitin-conjugating enzyme E2W (putative) | -2.09281 |
| KRT14 | keratin 14, type I | -2.088 |
| DDX6 | DEAD (Asp-Glu-Ala-Asp) box helicase 6 | -2.0818 |
| SRSF2 | serine/arginine-rich splicing factor 2 | -2.06448 |
| SULT4A1 | sulfotransferase family 4A, member 1 | -2.05764 |
| CLEC16A | C-type lectin domain family 16, member A | -2.05076 |
| HTR1E | 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled | -2.04952 |
| OXSR1 | oxidative stress responsive 1 | -2.04661 |
| ATF5 | activating transcription factor 5 | -2.03885 |
| TDRD12 | tudor domain containing 12 | -2.03799 |
| BMP2 | bone morphogenetic protein 2 | -2.03403 |
| PCDHGA9 | protocadherin gamma subfamily A, 9 | -2.02242 |
| KRT15 | keratin 15, type I | -2.0187 |
| MRPL44 | mitochondrial ribosomal protein L44 | -2.01362 |
| ADRB2 | adrenoceptor beta 2, surface | -2.00991 |
| OR5I1 | olfactory receptor, family 5, subfamily I, member 1 | -2.00297 |
| VGLL3 | vestigial-like family member 3 | -2.00281 |
| CYP4B1 | cytochrome P450, family 4, subfamily B, polypeptide 1 | -2.00123 |
