CRCGN017_MCF10A.TP53.M_24H:H12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tetracycline 11.27 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

60 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:H12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 6.2712
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 5.47029
ASNS asparagine synthetase (glutamine-hydrolyzing) 5.13553
PHGDH phosphoglycerate dehydrogenase 4.64147
PYCR1 pyrroline-5-carboxylate reductase 1 4.53956
SPAG4 sperm associated antigen 4 4.31818
AARS1 alanyl-tRNA synthetase 1 4.21234
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 4.14084
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.02934
GRB10 growth factor receptor-bound protein 10 3.60606
PSAT1 phosphoserine aminotransferase 1 3.5541
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 3.54415
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 3.42385
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 3.41941
UBQLN2 ubiquilin 2 3.41203
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 3.24597
TRIB3 tribbles pseudokinase 3 3.18557
GARS1 glycyl-tRNA synthetase 1 3.09617
ATF4 activating transcription factor 4 3.08834
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) 3.00339
YARS1 tyrosyl-tRNA synthetase 1 2.91936
MAMLD1 mastermind-like domain containing 1 2.8031
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 2.66864
SARS1 seryl-tRNA synthetase 1 2.66316
HAX1 HCLS1 associated protein X-1 2.62854
XPOT exportin, tRNA 2.60545
FOS FBJ murine osteosarcoma viral oncogene homolog 2.57564
BDH1 3-hydroxybutyrate dehydrogenase, type 1 2.55348
IARS1 isoleucyl-tRNA synthetase 1 2.54753
CARS1 cysteinyl-tRNA synthetase 1 2.53347
NLRP4 NLR family, pyrin domain containing 4 2.47418
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma 2.40651
MARS1 methionyl-tRNA synthetase 1 2.39782
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.39085
EPRS1 glutamyl-prolyl-tRNA synthetase 1 2.35991
LOC128125814 uncharacterized LOC128125814 2.34876
COMP cartilage oligomeric matrix protein 2.31155
OARD1 O-acyl-ADP-ribose deacylase 1 2.27205
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 2.25564
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 2.17178
ANKRD11 ankyrin repeat domain 11 2.17077
DHRS4 dehydrogenase/reductase (SDR family) member 4 2.16195
TARS1 threonyl-tRNA synthetase 1 2.07987

decreased expression

Symbol Name Standardized Value
TUBB6 tubulin, beta 6 class V -4.18821
GOLT1B golgi transport 1B -3.37338
UFM1 ubiquitin-fold modifier 1 -2.9687
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.81897
RNF167 ring finger protein 167 -2.7057
HEATR1 HEAT repeat containing 1 -2.62178
INSIG1 insulin induced gene 1 -2.59769
BASP1 brain abundant, membrane attached signal protein 1 -2.5473
TUBA4A tubulin, alpha 4a -2.45371
STXBP2 syntaxin binding protein 2 -2.23777
SRFBP1 serum response factor binding protein 1 -2.1388
GPRC5A G protein-coupled receptor, class C, group 5, member A -2.07572
S100A4 S100 calcium binding protein A4 -2.04873
DEPDC5 DEP domain containing 5 -2.02791
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase -2.0224
HSPB1 heat shock 27kDa protein 1 -2.00979
KRT14 keratin 14, type I -2.00342