CRCGN017_MCF10A.TP53.M_24H:H16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description caffeine 101.98 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

122 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:H16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 5.22568
HMOX1 heme oxygenase 1 4.94237
TXNRD1 thioredoxin reductase 1 4.69409
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 4.5002
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 4.1446
ASNS asparagine synthetase (glutamine-hydrolyzing) 3.11871
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.91157
ALDOC aldolase C, fructose-bisphosphate 2.79899
PHGDH phosphoglycerate dehydrogenase 2.7545
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.65401
GLRX glutaredoxin (thioltransferase) 2.62108
KDM5A lysine (K)-specific demethylase 5A 2.61773
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.60963
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.55654
XPOT exportin, tRNA 2.51012
IARS1 isoleucyl-tRNA synthetase 1 2.48953
TRIB3 tribbles pseudokinase 3 2.45346
CLNS1A chloride channel, nucleotide-sensitive, 1A 2.42098
BAG2 BCL2-associated athanogene 2 2.42039
ACAA1 acetyl-CoA acyltransferase 1 2.3887
GARS1 glycyl-tRNA synthetase 1 2.36039
CTSL cathepsin L 2.31834
RBP4 retinol binding protein 4, plasma 2.30588
MRPL48 mitochondrial ribosomal protein L48 2.30265
PROCR protein C receptor, endothelial 2.28476
MID1IP1 MID1 interacting protein 1 2.27084
CERS2 ceramide synthase 2 2.2377
INPP1 inositol polyphosphate-1-phosphatase 2.23049
SPRR3 small proline-rich protein 3 2.19168
CDK7 cyclin-dependent kinase 7 2.15627
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.15537
RHOB ras homolog family member B 2.12763
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 2.11671
VLDLR very low density lipoprotein receptor 2.10424
GFPT1 glutamine--fructose-6-phosphate transaminase 1 2.09255
COCH cochlin 2.08992
DKK1 dickkopf WNT signaling pathway inhibitor 1 2.08536
KLF2 Kruppel-like factor 2 2.07343
ACY1 aminoacylase 1 2.04936
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) 2.03982
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 2.02381
SLC35G2 solute carrier family 35, member G2 2.01764
CXCL8 chemokine (C-X-C motif) ligand 8 2.00379

decreased expression

Symbol Name Standardized Value
KRT14 keratin 14, type I -5.51244
CTNND1 catenin (cadherin-associated protein), delta 1 -4.31258
COG7 component of oligomeric golgi complex 7 -4.24249
HAT1 histone acetyltransferase 1 -3.99885
PUF60 poly-U binding splicing factor 60KDa -3.588
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.53497
NCAPD2 non-SMC condensin I complex, subunit D2 -3.37821
PSRC1 proline/serine-rich coiled-coil 1 -3.34103
PCNA proliferating cell nuclear antigen -3.30386
PLK1 polo-like kinase 1 -3.12746
TENT4A terminal nucleotidyltransferase 4A -3.10301
CCNB2 cyclin B2 -3.08389
AGBL5 ATP/GTP binding protein-like 5 -2.93659
CDC20 cell division cycle 20 -2.83902
PARP2 poly (ADP-ribose) polymerase 2 -2.75142
CDCA8 cell division cycle associated 8 -2.72241
OSGEP O-sialoglycoprotein endopeptidase -2.71291
TRAPPC3 trafficking protein particle complex 3 -2.66887
NUSAP1 nucleolar and spindle associated protein 1 -2.65584
DNALI1 dynein, axonemal, light intermediate chain 1 -2.64546
DSG2 desmoglein 2 -2.62487
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -2.57664
CD101 CD101 molecule -2.55986
TEP1 telomerase-associated protein 1 -2.54704
NRIP1 nuclear receptor interacting protein 1 -2.54222
KIF20A kinesin family member 20A -2.52078
KRT15 keratin 15, type I -2.51846
RBBP8 retinoblastoma binding protein 8 -2.51058
CCNB1 cyclin B1 -2.47387
PPP4C protein phosphatase 4, catalytic subunit -2.44712
DRC11 dynein regulatory complex subunit 11 -2.44488
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 -2.43958
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) -2.39926
ARRB2 arrestin, beta 2 -2.37459
BEND5 BEN domain containing 5 -2.3643
MXD3 MAX dimerization protein 3 -2.29706
CYB5RL cytochrome b5 reductase-like -2.28669
CSPG5 chondroitin sulfate proteoglycan 5 (neuroglycan C) -2.26789
CYBRD1 cytochrome b reductase 1 -2.26425
MKKS McKusick-Kaufman syndrome -2.25385
NCAN neurocan -2.23728
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 -2.22302
ZNF629 zinc finger protein 629 -2.21647
JRK Jrk homolog (mouse) -2.19951
CCDC25 coiled-coil domain containing 25 -2.1943
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4 -2.17321
CRNKL1 crooked neck pre-mRNA splicing factor 1 -2.16199
IER5 immediate early response 5 -2.1568
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae) -2.15457
KIF22 kinesin family member 22 -2.14939
ZNF587B zinc finger protein 587B -2.14267
STAB1 stabilin 1 -2.13065
CDK20 cyclin-dependent kinase 20 -2.12046
TNIP1 TNFAIP3 interacting protein 1 -2.11783
VPS35L VPS35 endosomal protein sorting factor like -2.11009
HDAC3 histone deacetylase 3 -2.10662
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) -2.1056
DOK2 docking protein 2, 56kDa -2.09652
KIF15 kinesin family member 15 -2.09442
CCR2 chemokine (C-C motif) receptor 2 -2.09405
MRPS15 mitochondrial ribosomal protein S15 -2.09048
NRBP1 nuclear receptor binding protein 1 -2.08902
CLBA1 clathrin binding box of aftiphilin containing 1 -2.07405
LALBA lactalbumin, alpha- -2.07201
COL9A1 collagen, type IX, alpha 1 -2.06191
SORBS3 sorbin and SH3 domain containing 3 -2.05978
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 -2.05642
FRZB frizzled-related protein -2.05154
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1 -2.04849
IFT22 intraflagellar transport 22 -2.04204
HMG20B high mobility group 20B -2.04177
COPS7A COP9 signalosome subunit 7A -2.02907
CSN1S1 casein alpha s1 -2.02499
BBOF1 basal body orientation factor 1 -2.0237
UBAC1 UBA domain containing 1 -2.02172
CNTLN centlein, centrosomal protein -2.01882
ARC activity-regulated cytoskeleton-associated protein -2.0122
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) -2.00454
HIRIP3 HIRA interacting protein 3 -2.0043