CRCGN017_MCF10A.TP53.M_24H:H18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description caffeine 11.33 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

18 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:H18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.73793
PLEKHJ1 pleckstrin homology domain containing, family J member 1 2.67912
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 2.63838
ACAA1 acetyl-CoA acyltransferase 1 2.54844
MCUR1 mitochondrial calcium uniporter regulator 1 2.51985
RAB31 RAB31, member RAS oncogene family 2.47625
HDGFL3 HDGF like 3 2.46557
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 2.36426
HBA1 hemoglobin, alpha 1 2.29632
TUBB6 tubulin, beta 6 class V 2.12063

decreased expression

Symbol Name Standardized Value
TXNDC9 thioredoxin domain containing 9 -4.09369
HSPA8 heat shock 70kDa protein 8 -3.67991
TUBA4A tubulin, alpha 4a -3.55954
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.67087
BASP1 brain abundant, membrane attached signal protein 1 -2.37652
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.35444
CLTB clathrin, light chain B -2.24288
SPAG7 sperm associated antigen 7 -2.0207