CRCGN017_MCF10A.TP53.M_24H:H19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,3-propane sultone 100.3 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

37 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:H19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 4.5025
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.93897
RPL39L ribosomal protein L39-like 3.6011
SPAG4 sperm associated antigen 4 3.49813
C2CD2 C2 calcium-dependent domain containing 2 3.4545
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.375
CCP110 centriolar coiled coil protein 110kDa 3.18073
PPARG peroxisome proliferator-activated receptor gamma 3.14223
KDM5D lysine (K)-specific demethylase 5D 3.0007
ABHD6 abhydrolase domain containing 6 2.78211
HBA1 hemoglobin, alpha 1 2.48646
CCL2 chemokine (C-C motif) ligand 2 2.4253
ITFG1 integrin alpha FG-GAP repeat containing 1 2.3766
KIF5C kinesin family member 5C 2.2004
IDE insulin-degrading enzyme 2.18716
OLFML2B olfactomedin-like 2B 2.1449
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 2.0426

decreased expression

Symbol Name Standardized Value
TCTA T-cell leukemia translocation altered -3.86803
TES testin LIM domain protein -3.7196
TNIP1 TNFAIP3 interacting protein 1 -3.69817
UFM1 ubiquitin-fold modifier 1 -3.6558
KIF14 kinesin family member 14 -3.56727
HACD3 3-hydroxyacyl-CoA dehydratase 3 -3.36827
BASP1 brain abundant, membrane attached signal protein 1 -3.25067
KRT14 keratin 14, type I -3.1166
BAG3 BCL2-associated athanogene 3 -3.09443
LYPLA1 lysophospholipase I -2.91823
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.87913
TUBB6 tubulin, beta 6 class V -2.6458
GOLT1B golgi transport 1B -2.64293
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.49307
SMC1A structural maintenance of chromosomes 1A -2.23852
GRN granulin -2.23461
OXA1L oxidase (cytochrome c) assembly 1-like -2.09327
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 -2.092
MAP2K1 mitogen-activated protein kinase kinase 1 -2.06393
MSN moesin -2.02503