CRCGN017_MCF10A.TP53.M_24H:H21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,3-propane sultone 11.14 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

65 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:H21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABHD6 abhydrolase domain containing 6 5.18359
SNAP25 synaptosomal-associated protein, 25kDa 5.14071
AMDHD2 amidohydrolase domain containing 2 4.91547
UBQLN2 ubiquilin 2 4.88484
ACLY ATP citrate lyase 3.20585
RBP4 retinol binding protein 4, plasma 3.02951
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 2.96034
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.88487
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 2.80955
NEFM neurofilament, medium polypeptide 2.66081
STMN2 stathmin 2 2.62984
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.54431
SCT secretin 2.46222
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 2.44848
SYT1 synaptotagmin I 2.43154
PLSCR3 phospholipid scramblase 3 2.41594
NEFL neurofilament, light polypeptide 2.40759
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A 2.39325
DHDDS dehydrodolichyl diphosphate synthase 2.37236
SULT4A1 sulfotransferase family 4A, member 1 2.36322
SNCB synuclein, beta 2.35508
SYP synaptophysin 2.35422
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 2.34935
APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F 2.34556
TPD52L2 tumor protein D52-like 2 2.34338
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.27845
SV2B synaptic vesicle glycoprotein 2B 2.27293
OLFM1 olfactomedin 1 2.24357
EDIL3 EGF-like repeats and discoidin I-like domains 3 2.23147
SCGN secretagogin, EF-hand calcium binding protein 2.22898
NPTXR neuronal pentraxin receptor 2.21488
SAMD14 sterile alpha motif domain containing 14 2.17929
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta 2.16745
SCG2 secretogranin II 2.13693
GNG3 guanine nucleotide binding protein (G protein), gamma 3 2.11851
BAHCC1 BAH domain and coiled-coil containing 1 2.11698
OLFML2B olfactomedin-like 2B 2.08714
PPP2R5D protein phosphatase 2, regulatory subunit B', delta 2.05106
SYN1 synapsin I 2.04376
KRT3 keratin 3, type II 2.03765
DCLK1 doublecortin-like kinase 1 2.02875
PYCR3 pyrroline-5-carboxylate reductase 3 2.02841
VRTN vertebrae development associated 2.00778

decreased expression

Symbol Name Standardized Value
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -5.08537
TRAPPC3 trafficking protein particle complex 3 -4.74991
TMCO1 transmembrane and coiled-coil domains 1 -3.86991
GDF15 growth differentiation factor 15 -2.89278
MSMO1 methylsterol monooxygenase 1 -2.76965
GNL2 guanine nucleotide binding protein-like 2 (nucleolar) -2.66434
CNIH1 cornichon family AMPA receptor auxiliary protein 1 -2.47165
MEAF6 MYST/Esa1-associated factor 6 -2.46334
RALGDS ral guanine nucleotide dissociation stimulator -2.45259
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) -2.43417
OXCT1 3-oxoacid CoA transferase 1 -2.36265
S100PBP S100P binding protein -2.35103
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -2.32764
SLC41A3 solute carrier family 41, member 3 -2.32727
CCDC47 coiled-coil domain containing 47 -2.30622
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -2.28195
F5 coagulation factor V (proaccelerin, labile factor) -2.17226
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.16536
EIF3I eukaryotic translation initiation factor 3, subunit I -2.15156
RTRAF RNA transcription, translation and transport factor -2.06202
BGLAP bone gamma-carboxyglutamate (gla) protein -2.05799
ZMYM4 zinc finger, MYM-type 4 -2.03123