CRCGN017_MCF10A.TP53.M_24H:I03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description o-aminoazotoluene 11.09 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

38 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:I03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 3.28834
GARRE1 granule associated Rac and RHOG effector 1 2.76446
AGR2 anterior gradient 2 2.7558
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.73493
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 2.34909
ATMIN ATM interactor 2.33178
TRAPPC8 trafficking protein particle complex 8 2.21098
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.11434
TMEM165 transmembrane protein 165 2.08875
LGMN legumain 2.08189
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7 2.0817
CNRIP1 cannabinoid receptor interacting protein 1 2.00588

decreased expression

Symbol Name Standardized Value
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.79542
DNM1L dynamin 1-like -4.50242
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -4.43575
MSMO1 methylsterol monooxygenase 1 -4.20745
NUSAP1 nucleolar and spindle associated protein 1 -3.96552
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -3.29268
CCDC86 coiled-coil domain containing 86 -3.17947
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.1649
RPIA ribose 5-phosphate isomerase A -3.16053
GDF15 growth differentiation factor 15 -3.12548
CD44 CD44 molecule (Indian blood group) -3.12246
NGRN neugrin, neurite outgrowth associated -2.92773
SINHCAF SIN3-HDAC complex associated factor -2.72041
RNF167 ring finger protein 167 -2.6856
THAP11 THAP domain containing 11 -2.42648
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide -2.32275
CD3E CD3e molecule, epsilon (CD3-TCR complex) -2.30025
NUP155 nucleoporin 155kDa -2.24471
IL10RA interleukin 10 receptor, alpha -2.19883
IL13 interleukin 13 -2.16907
GTF3C3 general transcription factor IIIC, polypeptide 3, 102kDa -2.14611
CAPRIN2 caprin family member 2 -2.12904
DCLRE1B DNA cross-link repair 1B -2.10495
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -2.06986
CD3D CD3d molecule, delta (CD3-TCR complex) -2.03657
PRC1 protein regulator of cytokinesis 1 -2.01264