CRCGN017_MCF10A.TP53.M_24H:I04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description isoniazid 100.3 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

57 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:I04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MOK MOK protein kinase 4.81866
SPAG4 sperm associated antigen 4 4.8066
ADGRE5 adhesion G protein-coupled receptor E5 4.18691
UBQLN2 ubiquilin 2 4.18269
CCP110 centriolar coiled coil protein 110kDa 3.59519
KLHL9 kelch-like family member 9 3.23405
TBX2 T-box 2 3.2228
COQ8A coenzyme Q8A 2.80784
DSTN destrin (actin depolymerizing factor) 2.28562
KCTD11 potassium channel tetramerization domain containing 11 2.28104
COMMD8 COMM domain containing 8 2.1246
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2 2.1178
ACOT9 acyl-CoA thioesterase 9 2.11006
HBB hemoglobin, beta 2.09335
MELK maternal embryonic leucine zipper kinase 2.05771
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.03718

decreased expression

Symbol Name Standardized Value
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.96103
MSMO1 methylsterol monooxygenase 1 -4.81113
PTK2 protein tyrosine kinase 2 -4.02989
PCCB propionyl CoA carboxylase, beta polypeptide -3.91064
SCYL3 SCY1-like 3 (S. cerevisiae) -3.90861
TMEM115 transmembrane protein 115 -3.60486
CAB39 calcium binding protein 39 -3.50523
FASN fatty acid synthase -3.3483
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.23225
IFRD2 interferon-related developmental regulator 2 -3.15128
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 -3.04674
TGM4 transglutaminase 4 -2.65493
APEH acylaminoacyl-peptide hydrolase -2.41071
ACTR8 ARP8 actin-related protein 8 homolog (yeast) -2.40466
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -2.35713
CEP72 centrosomal protein 72kDa -2.33604
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -2.30007
EDC3 enhancer of mRNA decapping 3 -2.25438
FBLN2 fibulin 2 -2.24728
IL23A interleukin 23, alpha subunit p19 -2.23128
RNF123 ring finger protein 123 -2.22197
MAST3 microtubule associated serine/threonine kinase 3 -2.21361
PDPN podoplanin -2.21193
MAP3K8 mitogen-activated protein kinase kinase kinase 8 -2.15041
EPYC epiphycan -2.14047
TUBAL3 tubulin, alpha-like 3 -2.12667
IRF8 interferon regulatory factor 8 -2.12538
CDYL chromodomain protein, Y-like -2.09995
COL8A2 collagen, type VIII, alpha 2 -2.09932
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) -2.08864
C1QTNF3 C1q and tumor necrosis factor related protein 3 -2.08235
NPTXR neuronal pentraxin receptor -2.08138
THBS4 thrombospondin 4 -2.06286
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 -2.05527
DLK2 delta-like 2 homolog (Drosophila) -2.05006
WNT5A wingless-type MMTV integration site family, member 5A -2.04593
RPP38 ribonuclease P/MRP 38kDa subunit -2.04417
NR1D2 nuclear receptor subfamily 1, group D, member 2 -2.01018
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 -2.00867
PDE4B phosphodiesterase 4B, cAMP-specific -2.00669
RAB15 RAB15, member RAS oncogene family -2.00564