CRCGN017_MCF10A.TP53.M_24H:I06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description isoniazid 11.14 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

16 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:I06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCL2 chemokine (C-X-C motif) ligand 2 4.95194
VAV3 vav 3 guanine nucleotide exchange factor 4.47842
IGHMBP2 immunoglobulin mu binding protein 2 3.62657
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.86938
PARP1 poly (ADP-ribose) polymerase 1 2.22417
ACAA1 acetyl-CoA acyltransferase 1 2.15732
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) 2.06067
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 2.04612

decreased expression

Symbol Name Standardized Value
DERA deoxyribose-phosphate aldolase (putative) -5.07567
RPIA ribose 5-phosphate isomerase A -4.99312
ISOC1 isochorismatase domain containing 1 -3.88775
CHIC2 cysteine-rich hydrophobic domain 2 -3.092
YME1L1 YME1-like 1 ATPase -2.98177
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -2.94953
COG7 component of oligomeric golgi complex 7 -2.51214
ABI1 abl-interactor 1 -2.01067