CRCGN017_MCF10A.TP53.M_24H:I08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description roxarsone 33.1 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

55 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:I08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAMLD1 mastermind-like domain containing 1 4.33788
CXCR4 chemokine (C-X-C motif) receptor 4 4.28216
LAGE3 L antigen family, member 3 3.59161
MCUR1 mitochondrial calcium uniporter regulator 1 3.23007
STK10 serine/threonine kinase 10 2.96273
SQOR sulfide quinone oxidoreductase 2.93753
OLFML2B olfactomedin-like 2B 2.89325
MICALL1 MICAL-like 1 2.81688
HBB hemoglobin, beta 2.68708
HBA1 hemoglobin, alpha 1 2.66006
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.59589
TUFM Tu translation elongation factor, mitochondrial 2.53265
CENPE centromere protein E, 312kDa 2.27073
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 2.2399
LASP1 LIM and SH3 protein 1 2.21616
MOGAT1 monoacylglycerol O-acyltransferase 1 2.12458
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 2.10369
CAPN1 calpain 1, (mu/I) large subunit 2.08048
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 2.04893
DPH2 DPH2 homolog (S. cerevisiae) 2.03916
ARID4B AT rich interactive domain 4B (RBP1-like) 2.03532

decreased expression

Symbol Name Standardized Value
GDF15 growth differentiation factor 15 -5.4832
HMG20B high mobility group 20B -4.64131
CYCS cytochrome c, somatic -4.55103
TCTA T-cell leukemia translocation altered -4.27855
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -4.2234
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.92875
NSDHL NAD(P) dependent steroid dehydrogenase-like -3.87212
BAG3 BCL2-associated athanogene 3 -3.60108
CDC25B cell division cycle 25B -3.35687
RBM34 RNA binding motif protein 34 -2.97453
TRIB3 tribbles pseudokinase 3 -2.87991
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -2.79767
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -2.49779
BSG basigin (Ok blood group) -2.48781
HILPDA hypoxia inducible lipid droplet-associated -2.4239
CDK18 cyclin-dependent kinase 18 -2.26071
TUBA3E tubulin, alpha 3e -2.23124
FASN fatty acid synthase -2.2147
H2BC5 H2B clustered histone 5 -2.19059
TLE5 TLE family member 5, transcriptional modulator -2.172
RPF1 ribosome production factor 1 homolog (S. cerevisiae) -2.17186
ENO2 enolase 2 (gamma, neuronal) -2.15634
MTERF3 mitochondrial transcription termination factor 3 -2.13549
SDC4 syndecan 4 -2.10492
MXI1 MAX interactor 1, dimerization protein -2.10422
CDC34 cell division cycle 34 -2.09359
HAND1 heart and neural crest derivatives expressed 1 -2.09056
H2BC9 H2B clustered histone 9 -2.07307
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 -2.06494
THAP11 THAP domain containing 11 -2.05742
TUBA3C tubulin, alpha 3c -2.0469
YJU2 YJU2 splicing factor homolog -2.03896
RNF126 ring finger protein 126 -2.02682
ZNF557 zinc finger protein 557 -2.02358