CRCGN017_MCF10A.TP53.M_24H:I09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description roxarsone 11.03 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

41 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:I09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
VAV3 vav 3 guanine nucleotide exchange factor 4.91847
TSEN2 TSEN2 tRNA splicing endonuclease subunit 4.7556
AGR2 anterior gradient 2 4.75211
PRKCH protein kinase C, eta 4.21691
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.13633
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 4.01301
E2F2 E2F transcription factor 2 3.57495
ACE2 angiotensin I converting enzyme 2 2.76797
CCNF cyclin F 2.73736
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.55694
SLC75A1 solute carrier family 75 member 1 2.26676
LOC128966597 MAL-like protein 2.26029
IFITM1 interferon induced transmembrane protein 1 2.25368
IL18 interleukin 18 2.21573
SIRAL2 SIR2 antiphage like 2 2.21404
DTX4 deltex 4, E3 ubiquitin ligase 2.19318
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.18821
HKDC1 hexokinase domain containing 1 2.18645
NKG7 natural killer cell granule protein 7 2.17503
RBM47 RNA binding motif protein 47 2.10414
ZBP1 Z-DNA binding protein 1 2.08068
SATB1 SATB homeobox 1 2.04063
USP19 ubiquitin specific peptidase 19 2.00532
YBX3 Y box binding protein 3 2.00525
TSPAN13 tetraspanin 13 2.00021

decreased expression

Symbol Name Standardized Value
COTL1 coactosin-like F-actin binding protein 1 -5.70603
HMG20B high mobility group 20B -5.0335
ENOPH1 enolase-phosphatase 1 -4.83405
GDF15 growth differentiation factor 15 -3.80414
ADI1 acireductone dioxygenase 1 -3.64244
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -2.52348
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.51482
TFF3 trefoil factor 3 (intestinal) -2.37733
BASP1 brain abundant, membrane attached signal protein 1 -2.24645
KDM3A lysine (K)-specific demethylase 3A -2.19709
FAM174B family with sequence similarity 174, member B -2.08305
RGS2 regulator of G-protein signaling 2 -2.06051
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -2.04746
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha -2.02612
UVRAG UV radiation resistance associated -2.0106
RAI14 retinoic acid induced 14 -2.00412