CRCGN017_MCF10A.TP53.M_24H:I15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description trans-cinnamaldehyde 11.2 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

46 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:I15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.94778
EPHB2 EPH receptor B2 3.72045
PPOX protoporphyrinogen oxidase 3.40186
DHRS2 dehydrogenase/reductase (SDR family) member 2 3.30456
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 3.12224
UGDH UDP-glucose 6-dehydrogenase 3.04763
ACAA1 acetyl-CoA acyltransferase 1 2.94325
CIRBP cold inducible RNA binding protein 2.66934
MELK maternal embryonic leucine zipper kinase 2.64096
TOMM34 translocase of outer mitochondrial membrane 34 2.25823
TYK2 tyrosine kinase 2 2.25258
NTHL1 nth endonuclease III-like 1 (E. coli) 2.09397
ZNF211 zinc finger protein 211 2.069
KLF2 Kruppel-like factor 2 2.06013
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 2.0529

decreased expression

Symbol Name Standardized Value
DERA deoxyribose-phosphate aldolase (putative) -4.46006
PUF60 poly-U binding splicing factor 60KDa -4.17583
PCNA proliferating cell nuclear antigen -3.42654
CCNB1 cyclin B1 -3.25353
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.04813
RNF167 ring finger protein 167 -2.94542
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.77808
C1QBP complement component 1, q subcomponent binding protein -2.72959
C2CD5 C2 calcium-dependent domain containing 5 -2.72528
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide -2.72172
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma -2.5681
TOMM70 translocase of outer mitochondrial membrane 70 -2.54607
MSMO1 methylsterol monooxygenase 1 -2.37013
PBLD phenazine biosynthesis-like protein domain containing -2.32703
SCRIB scribbled planar cell polarity protein -2.28288
ANKRD44 ankyrin repeat domain 44 -2.23918
FGF4 fibroblast growth factor 4 -2.23774
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12 -2.21014
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 -2.205
WBP11 WW domain binding protein 11 -2.16633
MRPS17 mitochondrial ribosomal protein S17 -2.15708
AVL9 AVL9 homolog (S. cerevisiase) -2.1354
HPS4 Hermansky-Pudlak syndrome 4 -2.09719
RAB38 RAB38, member RAS oncogene family -2.08556
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) -2.07995
KRT14 keratin 14, type I -2.0788
ABHD6 abhydrolase domain containing 6 -2.05235
MAN2A1 mannosidase, alpha, class 2A, member 1 -2.04846
PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1 -2.04804
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -2.04652
GPAA1 glycosylphosphatidylinositol anchor attachment 1 -2.03913