CRCGN017_MCF10A.TP53.M_24H:I16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description xylene mixture (60% m-xylene, 9% o-xylene, 14% p-xylene, 17% ethylbenzene) 96.8 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

26 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:I16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RPL39L ribosomal protein L39-like 3.99158
GARRE1 granule associated Rac and RHOG effector 1 3.37901
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.20918
EVL Enah/Vasp-like 2.61337
TNIP1 TNFAIP3 interacting protein 1 2.57393
COQ8A coenzyme Q8A 2.45696
WIF1 WNT inhibitory factor 1 2.31802
IGFBP3 insulin-like growth factor binding protein 3 2.29122
CETN3 centrin, EF-hand protein, 3 2.27792
MCUR1 mitochondrial calcium uniporter regulator 1 2.27537
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.27379
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.18005
COMP cartilage oligomeric matrix protein 2.07208

decreased expression

Symbol Name Standardized Value
HMG20B high mobility group 20B -6.13797
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -4.00092
GDF15 growth differentiation factor 15 -2.88296
PIH1D1 PIH1 domain containing 1 -2.67898
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -2.60843
TRIB3 tribbles pseudokinase 3 -2.50335
PLP2 proteolipid protein 2 (colonic epithelium-enriched) -2.37759
MTFR1 mitochondrial fission regulator 1 -2.29043
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.25785
TUBA4A tubulin, alpha 4a -2.06763
ANKRD10 ankyrin repeat domain 10 -2.03332
KDM3A lysine (K)-specific demethylase 3A -2.03221
SMNDC1 survival motor neuron domain containing 1 -2.00236