CRCGN017_MCF10A.TP53.M_24H:I17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description xylene mixture (60% m-xylene, 9% o-xylene, 14% p-xylene, 17% ethylbenzene) 32.27 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

244 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:I17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 5.29425
ABHD4 abhydrolase domain containing 4 5.2701
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 4.68625
CXCR4 chemokine (C-X-C motif) receptor 4 4.1706
TSPAN6 tetraspanin 6 3.50852
OLFML2B olfactomedin-like 2B 3.4183
AGR2 anterior gradient 2 3.33875
GPRC5C G protein-coupled receptor, class C, group 5, member C 2.7968
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 2.47612
TSPAN1 tetraspanin 1 2.41165
NT5C 5', 3'-nucleotidase, cytosolic 2.396
HSPA4L heat shock 70kDa protein 4-like 2.3462
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 2.2179
MYBPC1 myosin binding protein C, slow type 2.2118
ATP5MC1 ATP synthase membrane subunit c locus 1 2.19325
ALOX5AP arachidonate 5-lipoxygenase-activating protein 2.1808
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 2.15365
SFXN1 sideroflexin 1 2.13955
CXXC1 CXXC finger protein 1 2.1357
GOLPH3L golgi phosphoprotein 3-like 2.1144
RIC8B RIC8 guanine nucleotide exchange factor B 2.11035
MSRB1 methionine sulfoxide reductase B1 2.10145
SLC41A3 solute carrier family 41, member 3 2.08445
HBA1 hemoglobin, alpha 1 2.05631
NIP7 NIP7, nucleolar pre-rRNA processing protein 2.0505
PRH1 proline-rich protein HaeIII subfamily 1 2.03485
PROS1 protein S (alpha) 2.02655
COPS7A COP9 signalosome subunit 7A 2.0199
FTO fat mass and obesity associated 2.01305

decreased expression

Symbol Name Standardized Value
PMM2 phosphomannomutase 2 -5.6615
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.1405
TUBB6 tubulin, beta 6 class V -4.79645
KRT14 keratin 14, type I -4.2675
GNAS GNAS complex locus -4.09959
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -3.94955
ATG3 autophagy related 3 -3.54017
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.5314
RGS2 regulator of G-protein signaling 2 -3.2227
SLC35A5 solute carrier family 35, member A5 -3.0594
KRT37 keratin 37, type I -2.917
CALM2 calmodulin 2 (phosphorylase kinase, delta) -2.82395
UNC5C unc-5 homolog C (C. elegans) -2.76605
CD200 CD200 molecule -2.75208
CCDC177 coiled-coil domain containing 177 -2.74355
GPR22 G protein-coupled receptor 22 -2.73865
TMOD2 tropomodulin 2 (neuronal) -2.72995
NIPSNAP3B nipsnap homolog 3B (C. elegans) -2.645
LATS1 large tumor suppressor kinase 1 -2.6193
MGAM2 maltase-glucoamylase 2 (putative) -2.60815
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 -2.5964
DNASE1 deoxyribonuclease I -2.57435
PEDS1 plasmanylethanolamine desaturase 1 -2.566
ENTREP2 endosomal transmembrane epsin interactor 2 -2.55735
NOTCH4 notch 4 -2.5563
BASP1 brain abundant, membrane attached signal protein 1 -2.55225
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -2.545
MMP16 matrix metallopeptidase 16 (membrane-inserted) -2.53377
NLGN4Y neuroligin 4, Y-linked -2.52905
LOC102723713 TP53-target gene 3 protein -2.5283
LGALS13 lectin, galactoside-binding, soluble, 13 -2.5218
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2 -2.4909
SRP9 signal recognition particle 9kDa -2.48315
DEFA5 defensin, alpha 5, Paneth cell-specific -2.4774
CPAMD8 C3 and PZP-like, alpha-2-macroglobulin domain containing 8 -2.4529
CNKSR2 connector enhancer of kinase suppressor of Ras 2 -2.44465
CCR8 chemokine (C-C motif) receptor 8 -2.44005
OR7A5 olfactory receptor, family 7, subfamily A, member 5 -2.43295
MAGEB4 melanoma antigen family B4 -2.4307
SOX11 SRY (sex determining region Y)-box 11 -2.42207
LRRTM4 leucine rich repeat transmembrane neuronal 4 -2.4215
EPPIN epididymal peptidase inhibitor -2.41463
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 -2.39935
LCT lactase -2.3944
SYT13 synaptotagmin XIII -2.39115
DEFA6 defensin, alpha 6, Paneth cell-specific -2.381
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled -2.37485
STON1-GTF2A1L STON1-GTF2A1L readthrough -2.36995
ZNF80 zinc finger protein 80 -2.3441
PDE5A phosphodiesterase 5A, cGMP-specific -2.3295
VAX2 ventral anterior homeobox 2 -2.3237
SRY sex determining region Y -2.3136
ZPBP zona pellucida binding protein -2.30315
MINAR1 membrane integral NOTCH2 associated receptor 1 -2.3024
USP29 ubiquitin specific peptidase 29 -2.29785
FGF7 fibroblast growth factor 7 -2.2978
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -2.2975
SPO11 SPO11 meiotic protein covalently bound to DSB -2.293
FAM13C family with sequence similarity 13, member C -2.2922
SLC25A30 solute carrier family 25, member 30 -2.28935
COLEC10 collectin sub-family member 10 (C-type lectin) -2.2832
MTMR7 myotubularin related protein 7 -2.27645
COPS7B COP9 signalosome subunit 7B -2.27495
CRYGB crystallin, gamma B -2.2729
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled -2.27185
TSPAN2 tetraspanin 2 -2.2717
NLGN1 neuroligin 1 -2.26985
KRT36 keratin 36, type I -2.26925
GFM1 G elongation factor, mitochondrial 1 -2.26205
GALR1 galanin receptor 1 -2.25925
IAPP islet amyloid polypeptide -2.2517
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 -2.25025
ZNF493 zinc finger protein 493 -2.24615
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -2.246
PAPOLB poly(A) polymerase beta (testis specific) -2.24315
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic) -2.232
CYLC2 cylicin, basic protein of sperm head cytoskeleton 2 -2.22425
PNLIPRP2 pancreatic lipase-related protein 2 -2.2241
LOC124907012 endogenous retrovirus group K member 7 Env polyprotein-like -2.22185
GSTT4 glutathione S-transferase theta 4 -2.21965
MAB21L4 mab-21 like 4 -2.21225
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -2.209
GML glycosylphosphatidylinositol anchored molecule like -2.20815
CCDC102B coiled-coil domain containing 102B -2.2018
SPATA1 spermatogenesis associated 1 -2.20015
MROH9 maestro heat-like repeat family member 9 -2.2
SP4 Sp4 transcription factor -2.19745
SYN2 synapsin II -2.19392
GCNT4 glucosaminyl (N-acetyl) transferase 4, core 2 -2.19275
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) -2.19235
RAVER2 ribonucleoprotein, PTB-binding 2 -2.18985
PRKN parkin RBR E3 ubiquitin protein ligase -2.18895
NALF1 NALCN channel auxiliary factor 1 -2.18685
MC4R melanocortin 4 receptor -2.1803
IL21 interleukin 21 -2.18025
PPEF2 protein phosphatase, EF-hand calcium binding domain 2 -2.18005
AMELX amelogenin, X-linked -2.1783
BTC betacellulin -2.1774
ADAM29 ADAM metallopeptidase domain 29 -2.1742
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7 -2.17275
TMEM186 transmembrane protein 186 -2.1725
ADGRL4 adhesion G protein-coupled receptor L4 -2.17135
CPA1 carboxypeptidase A1 (pancreatic) -2.17085
PGRMC2 progesterone receptor membrane component 2 -2.16948
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1 -2.1693
EGFL6 EGF-like-domain, multiple 6 -2.16895
PEX5L peroxisomal biogenesis factor 5-like -2.16765
MORC1 MORC family CW-type zinc finger 1 -2.1662
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1 -2.1619
OAT ornithine aminotransferase -2.15805
SYCP1 synaptonemal complex protein 1 -2.15665
REG3A regenerating islet-derived 3 alpha -2.15495
ZNF280A zinc finger protein 280A -2.1526
TRIM49D2 tripartite motif containing 49D2 -2.15035
RARS1 arginyl-tRNA synthetase 1 -2.1407
OR1A2 olfactory receptor, family 1, subfamily A, member 2 -2.1406
GRIK3 glutamate receptor, ionotropic, kainate 3 -2.13925
LCOR ligand dependent nuclear receptor corepressor -2.13765
ZNF492 zinc finger protein 492 -2.13645
ELOA2 elongin A2 -2.13525
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta -2.12585
ZNF223 zinc finger protein 223 -2.12395
STXBP5L syntaxin binding protein 5-like -2.1232
EMC7 ER membrane protein complex subunit 7 -2.11905
CCDC121 coiled-coil domain containing 121 -2.1189
MRGBP MRG/MORF4L binding protein -2.11855
REG1A regenerating islet-derived 1 alpha -2.1161
NSUN7 NOP2/Sun domain family, member 7 -2.1157
ATP8B3 ATPase, aminophospholipid transporter, class I, type 8B, member 3 -2.1147
FMO3 flavin containing monooxygenase 3 -2.1139
DLGAP2 discs, large (Drosophila) homolog-associated protein 2 -2.11347
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 -2.11182
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 -2.10895
TSSK1B testis-specific serine kinase 1B -2.10685
THAP9 THAP domain containing 9 -2.10685
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20 -2.1067
WDR26 WD repeat domain 26 -2.1052
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled -2.1051
CDH20 cadherin 20, type 2 -2.1032
PTGIS prostaglandin I2 (prostacyclin) synthase -2.10243
MCF2L2 MCF.2 cell line derived transforming sequence-like 2 -2.1018
CNTRL centriolin -2.1013
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic -2.10075
CLEC4E C-type lectin domain family 4, member E -2.0978
KRT24 keratin 24, type I -2.0967
CUZD1 CUB and zona pellucida-like domains 1 -2.0943
NPTX1 neuronal pentraxin I -2.09265
CNTNAP1 contactin associated protein 1 -2.09005
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4 -2.0883
KLHL11 kelch-like family member 11 -2.08825
ZNF529 zinc finger protein 529 -2.08785
SPACA1 sperm acrosome associated 1 -2.08715
HRH4 histamine receptor H4 -2.08637
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 -2.08627
TULP2 tubby like protein 2 -2.08295
KCNJ13 potassium channel, inwardly rectifying subfamily J, member 13 -2.07995
AGBL3 ATP/GTP binding protein-like 3 -2.0796
ZNF37A zinc finger protein 37A -2.0782
ADAM21 ADAM metallopeptidase domain 21 -2.0782
BMP8B bone morphogenetic protein 8b -2.0776
TAGLN3 transgelin 3 -2.07685
CRISP1 cysteine-rich secretory protein 1 -2.07623
SCN2A sodium channel, voltage gated, type II alpha subunit -2.07495
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -2.07325
RAP1B RAP1B, member of RAS oncogene family -2.0722
CHRM5 cholinergic receptor, muscarinic 5 -2.0678
TLL1 tolloid-like 1 -2.0673
KCNK2 potassium channel, two pore domain subfamily K, member 2 -2.0666
LOC100996709 ADP-ribosylation factor-like protein 17 -2.0657
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 -2.0629
CORT cortistatin -2.0605
LIMD2 LIM domain containing 2 -2.059
FAM135A family with sequence similarity 135, member A -2.05625
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -2.05605
EGR4 early growth response 4 -2.05538
ZNF345 zinc finger protein 345 -2.0511
SOX18 SRY (sex determining region Y)-box 18 -2.05085
RIT2 Ras-like without CAAX 2 -2.05
IFNA1 interferon, alpha 1 -2.04945
ZNF675 zinc finger protein 675 -2.0484
EXOC6B exocyst complex component 6B -2.04295
FXYD7 FXYD domain containing ion transport regulator 7 -2.04245
KLHL4 kelch-like family member 4 -2.0412
ZNF157 zinc finger protein 157 -2.04115
SPICE1 spindle and centriole associated protein 1 -2.03985
PHOX2B paired-like homeobox 2b -2.0396
EMILIN2 elastin microfibril interfacer 2 -2.0381
COL8A1 collagen, type VIII, alpha 1 -2.03737
TBR1 T-box, brain, 1 -2.0346
TAS2R1 taste receptor, type 2, member 1 -2.03215
PRDM9 PR domain containing 9 -2.0319
GTPBP10 GTP-binding protein 10 (putative) -2.03175
RIPPLY3 ripply transcriptional repressor 3 -2.03155
PABPC1 poly(A) binding protein, cytoplasmic 1 -2.0308
CA5B carbonic anhydrase VB, mitochondrial -2.02978
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 -2.02825
OPCML opioid binding protein/cell adhesion molecule-like -2.0282
GCM2 glial cells missing homolog 2 (Drosophila) -2.02735
AJAP1 adherens junctions associated protein 1 -2.02642
CCDC144A coiled-coil domain containing 144A -2.02595
KLHL3 kelch-like family member 3 -2.0229
RIMS1 regulating synaptic membrane exocytosis 1 -2.0165
DIAPH3 diaphanous-related formin 3 -2.0159
OR1E1 olfactory receptor, family 1, subfamily E, member 1 -2.0136
NKX3-2 NK3 homeobox 2 -2.01285
LAG3 lymphocyte-activation gene 3 -2.0126
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13 -2.01065
TAS2R3 taste receptor, type 2, member 3 -2.0091
CFAP68 cilia and flagella associated protein 68 -2.00775
CCNK cyclin K -2.00585
ZNF214 zinc finger protein 214 -2.0053
BEAN1 brain expressed, associated with NEDD4, 1 -2.0047
PRSS3 protease, serine, 3 -2.00402
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1 -2.00351
EDDM3B epididymal protein 3B -2.00175