| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | xylene mixture (60% m-xylene, 9% o-xylene, 14% p-xylene, 17% ethylbenzene) 10.76 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome) |
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53 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:I18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TLR4 | toll-like receptor 4 | 4.71231 |
| PPARG | peroxisome proliferator-activated receptor gamma | 4.68134 |
| HBA1 | hemoglobin, alpha 1 | 4.63563 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | 4.12337 |
| KDM5D | lysine (K)-specific demethylase 5D | 4.01332 |
| APOE | apolipoprotein E | 3.50277 |
| GATA2 | GATA binding protein 2 | 3.49515 |
| EIF1AY | eukaryotic translation initiation factor 1A, Y-linked | 3.25216 |
| AGR2 | anterior gradient 2 | 3.18707 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | 3.03324 |
| SLC35A1 | solute carrier family 35 (CMP-sialic acid transporter), member A1 | 3.02989 |
| CERK | ceramide kinase | 2.94752 |
| CEBPD | CCAAT/enhancer binding protein (C/EBP), delta | 2.8619 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | 2.72572 |
| NFATC3 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 | 2.68236 |
| USP9Y | ubiquitin specific peptidase 9, Y-linked | 2.51758 |
| LILRA6 | leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 | 2.51581 |
| HBB | hemoglobin, beta | 2.51156 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 2.47225 |
| FAM20B | family with sequence similarity 20, member B | 2.44668 |
| DENND2D | DENN/MADD domain containing 2D | 2.40504 |
| MTARC1 | mitochondrial amidoxime reducing component 1 | 2.37101 |
| FRAT2 | frequently rearranged in advanced T-cell lymphomas 2 | 2.20878 |
| MINDY1 | MINDY lysine 48 deubiquitinase 1 | 2.20049 |
| TOR4A | torsin family 4, member A | 2.168 |
| BZW2 | basic leucine zipper and W2 domains 2 | 2.1468 |
| IFT57 | intraflagellar transport 57 | 2.12309 |
| UTY | ubiquitously transcribed tetratricopeptide repeat containing, Y-linked | 2.1192 |
| LPL | lipoprotein lipase | 2.07165 |
| peptide deformylase (mitochondrial) | 2.0636 |
| Symbol | Name | Standardized Value |
|---|---|---|
| UFM1 | ubiquitin-fold modifier 1 | -5.38203 |
| COG2 | component of oligomeric golgi complex 2 | -4.76989 |
| ISOC1 | isochorismatase domain containing 1 | -4.36414 |
| TUBA4A | tubulin, alpha 4a | -3.7664 |
| G3BP1 | GTPase activating protein (SH3 domain) binding protein 1 | -3.72576 |
| SMNDC1 | survival motor neuron domain containing 1 | -3.63716 |
| JMJD6 | jumonji domain containing 6 | -3.36724 |
| LOC124905557 | eukaryotic translation initiation factor 1A, X-chromosomal | -2.78584 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -2.74646 |
| KDM6A | lysine (K)-specific demethylase 6A | -2.41463 |
| SMC1A | structural maintenance of chromosomes 1A | -2.29128 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -2.2863 |
| PLAU | plasminogen activator, urokinase | -2.21884 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -2.21133 |
| PRPSAP1 | phosphoribosyl pyrophosphate synthetase-associated protein 1 | -2.1971 |
| KDM5C | lysine (K)-specific demethylase 5C | -2.15805 |
| PUDP | pseudouridine 5'-phosphatase | -2.10873 |
| ZRSR2 | zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 | -2.10253 |
| PLK3 | polo-like kinase 3 | -2.09259 |
| DDX6 | DEAD (Asp-Glu-Ala-Asp) box helicase 6 | -2.08973 |
| AKAP17A | A kinase (PRKA) anchor protein 17A | -2.07064 |
| BCL10 | B-cell CLL/lymphoma 10 | -2.0239 |
| MTFR1 | mitochondrial fission regulator 1 | -2.01624 |
