CRCGN017_MCF10A.TP53.M_24H:I21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tributyl phosphate 11.11 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

52 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:I21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 5.31488
CORO1A coronin, actin binding protein, 1A 3.60736
MAST2 microtubule associated serine/threonine kinase 2 3.5639
DENND2D DENN/MADD domain containing 2D 3.29558
IL32 interleukin 32 2.69012
SESN1 sestrin 1 2.55367
PRKX protein kinase, X-linked 2.24293
EPHA1 EPH receptor A1 2.20958
MYBPC1 myosin binding protein C, slow type 2.17433
SPC25 SPC25, NDC80 kinetochore complex component 2.15323
DHRS4 dehydrogenase/reductase (SDR family) member 4 2.13901
HBB hemoglobin, beta 2.10866
ETHE1 ethylmalonic encephalopathy 1 2.10465
FBXO11 F-box protein 11 2.06735
PXMP2 peroxisomal membrane protein 2, 22kDa 2.03003

decreased expression

Symbol Name Standardized Value
UFM1 ubiquitin-fold modifier 1 -5.09904
NPDC1 neural proliferation, differentiation and control, 1 -4.64265
CREB1 cAMP responsive element binding protein 1 -3.71585
GNAS GNAS complex locus -3.68416
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -3.45781
CD320 CD320 molecule -3.41008
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.0366
VIM vimentin -2.83877
MED4 mediator complex subunit 4 -2.7911
POLR2M polymerase (RNA) II (DNA directed) polypeptide M -2.72887
NVL nuclear VCP-like -2.61575
TUBA1C tubulin, alpha 1c -2.61556
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.55111
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -2.52691
RPP38 ribonuclease P/MRP 38kDa subunit -2.42329
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) -2.41257
MOCS3 molybdenum cofactor synthesis 3 -2.2905
CCDC102B coiled-coil domain containing 102B -2.27387
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome) -2.27317
GDF15 growth differentiation factor 15 -2.26603
AKAP11 A kinase (PRKA) anchor protein 11 -2.24265
PRELID3B PRELI domain containing 3B -2.21017
RPN2 ribophorin II -2.20275
CALM2 calmodulin 2 (phosphorylase kinase, delta) -2.19697
NFYA nuclear transcription factor Y, alpha -2.16021
TUBA1B tubulin, alpha 1b -2.14117
PDE3B phosphodiesterase 3B, cGMP-inhibited -2.1355
LAMB1 laminin, beta 1 -2.13049
CNBP CCHC-type zinc finger, nucleic acid binding protein -2.09644
PROSER1 proline and serine rich 1 -2.08999
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -2.08897
CLCC1 chloride channel CLIC-like 1 -2.08012
NCAPD2 non-SMC condensin I complex, subunit D2 -2.07736
SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 -2.05407
MUC6 mucin 6, oligomeric mucus/gel-forming -2.04361
TRIB3 tribbles pseudokinase 3 -2.03626
NLRP1 NLR family, pyrin domain containing 1 -2.00454