CRCGN017_MCF10A.TP53.M_24H:J02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-chloro-p-phenylenediamine sulfate 33.27 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

71 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:J02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
STAP2 signal transducing adaptor family member 2 5.14965
ABHD6 abhydrolase domain containing 6 4.72357
TXNRD1 thioredoxin reductase 1 4.4834
ACAA1 acetyl-CoA acyltransferase 1 3.63722
DHRS2 dehydrogenase/reductase (SDR family) member 2 3.1485
HMOX1 heme oxygenase 1 3.03295
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.788
AGR2 anterior gradient 2 2.74385
TRIM13 tripartite motif containing 13 2.7218
SPANXA1 sperm protein associated with the nucleus, X-linked, family member A1 2.70992
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.60135
SYNGAP1 synaptic Ras GTPase activating protein 1 2.54195
NUCB2 nucleobindin 2 2.45925
GCLM glutamate-cysteine ligase, modifier subunit 2.4502
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14 2.4299
DACT1 dishevelled-binding antagonist of beta-catenin 1 2.3502
BEX4 brain expressed, X-linked 4 2.2686
SQSTM1 sequestosome 1 2.19325
SMC3 structural maintenance of chromosomes 3 2.15637
NUP54 nucleoporin 54kDa 2.14295
CENPE centromere protein E, 312kDa 2.12105
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 2.1156
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 2.07255
SEC24B SEC24 family member B 2.0294
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.02525
TRIM16 tripartite motif containing 16 2.0204

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -5.37525
CCDC86 coiled-coil domain containing 86 -5.33345
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -4.84035
DERA deoxyribose-phosphate aldolase (putative) -4.72255
WASHC4 WASH complex subunit 4 -4.27407
SCYL3 SCY1-like 3 (S. cerevisiae) -4.19072
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -3.95025
THAP11 THAP domain containing 11 -3.40625
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa -2.8201
RNF111 ring finger protein 111 -2.6824
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -2.669
TCP11 t-complex 11, testis-specific -2.66135
PSENEN presenilin enhancer gamma secretase subunit -2.60745
TBCB tubulin folding cofactor B -2.60558
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -2.51625
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin) -2.47755
GALNS galactosamine (N-acetyl)-6-sulfatase -2.438
H2AJ H2A.J histone -2.4305
POU4F1 POU class 4 homeobox 1 -2.41948
PCDHGA5 protocadherin gamma subfamily A, 5 -2.3214
PRUNE2 prune homolog 2 (Drosophila) -2.31417
ASRGL1 asparaginase like 1 -2.2646
HAUS5 HAUS augmin-like complex, subunit 5 -2.26385
ZBTB39 zinc finger and BTB domain containing 39 -2.23265
RAG1 recombination activating gene 1 -2.17025
CEP72 centrosomal protein 72kDa -2.16115
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2 -2.1529
GOLGA6B golgin A6 family, member B -2.12105
TUBGCP5 tubulin, gamma complex associated protein 5 -2.11515
CD81 CD81 molecule -2.1088
SCD5 stearoyl-CoA desaturase 5 -2.10855
LINS1 lines homolog 1 -2.0962
CHIA chitinase, acidic -2.09545
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa -2.08065
RBMXL2 RNA binding motif protein, X-linked-like 2 -2.0768
VPREB1 pre-B lymphocyte 1 -2.0546
LDHAL6B lactate dehydrogenase A-like 6B -2.04705
SNX1 sorting nexin 1 -2.04452
PARP6 poly (ADP-ribose) polymerase family, member 6 -2.0357
CCDC7 coiled-coil domain containing 7 -2.0292
PHOX2B paired-like homeobox 2b -2.0258
FAIM2 Fas apoptotic inhibitory molecule 2 -2.02355
SARS2 seryl-tRNA synthetase 2, mitochondrial -2.01315
RUBCNL rubicon like autophagy enhancer -2.0127
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled -2.0024