CRCGN017_MCF10A.TP53.M_24H:J05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4-nitro-o-phenylenediamine 33.27 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

99 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:J05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HMOX1 heme oxygenase 1 9.94678
TXNRD1 thioredoxin reductase 1 7.46397
NUCB2 nucleobindin 2 6.13837
BDH1 3-hydroxybutyrate dehydrogenase, type 1 4.96222
ABHD4 abhydrolase domain containing 4 4.17074
UGDH UDP-glucose 6-dehydrogenase 4.10928
SQSTM1 sequestosome 1 3.59982
OXSR1 oxidative stress responsive 1 3.50977
GLRX glutaredoxin (thioltransferase) 3.43483
TALDO1 transaldolase 1 3.11429
NQO1 NAD(P)H dehydrogenase, quinone 1 3.08281
TRIM16 tripartite motif containing 16 3.01001
HBA1 hemoglobin, alpha 1 2.87504
AKR1C3 aldo-keto reductase family 1, member C3 2.87302
SPAG4 sperm associated antigen 4 2.8451
MUC1 mucin 1, cell surface associated 2.83196
HSPB1 heat shock 27kDa protein 1 2.79926
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.77537
SYNE2 spectrin repeat containing, nuclear envelope 2 2.71914
LRP10 low density lipoprotein receptor-related protein 10 2.68298
CAPN1 calpain 1, (mu/I) large subunit 2.67951
CTSL cathepsin L 2.54418
ACAA1 acetyl-CoA acyltransferase 1 2.54141
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 2.5064
DENND2D DENN/MADD domain containing 2D 2.49422
FOXO4 forkhead box O4 2.48897
CNRIP1 cannabinoid receptor interacting protein 1 2.45955
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 2.43609
TSKU tsukushi, small leucine rich proteoglycan 2.42532
ANO10 anoctamin 10 2.36105
AKTIP AKT interacting protein 2.33311
IL32 interleukin 32 2.303
GCLM glutamate-cysteine ligase, modifier subunit 2.25588
MINDY1 MINDY lysine 48 deubiquitinase 1 2.21781
DHRS7 dehydrogenase/reductase (SDR family) member 7 2.20537
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.19494
CHMP1B charged multivesicular body protein 1B 2.18185
ASL argininosuccinate lyase 2.17111
GSR glutathione reductase 2.16184
HDGFL3 HDGF like 3 2.15494
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 2.14815
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3 2.13149
GFPT1 glutamine--fructose-6-phosphate transaminase 1 2.12388
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10 2.11234
SPAG7 sperm associated antigen 7 2.10906
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 2.10155
ERMP1 endoplasmic reticulum metallopeptidase 1 2.09038
PIGP phosphatidylinositol glycan anchor biosynthesis, class P 2.06632
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.05573
RNF103 ring finger protein 103 2.05467
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1 2.05283
SCYL3 SCY1-like 3 (S. cerevisiae) 2.05155
MSRB1 methionine sulfoxide reductase B1 2.04481
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 2.02602
UBE4A ubiquitination factor E4A 2.00988
IFI30 interferon, gamma-inducible protein 30 2.00913
OSBPL9 oxysterol binding protein-like 9 2.00875
HCAR3 hydroxycarboxylic acid receptor 3 2.00704
VDAC2 voltage-dependent anion channel 2 2.00109

decreased expression

Symbol Name Standardized Value
THAP11 THAP domain containing 11 -4.81908
HEATR1 HEAT repeat containing 1 -3.78544
GRWD1 glutamate-rich WD repeat containing 1 -3.63649
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -3.48847
NUSAP1 nucleolar and spindle associated protein 1 -3.43994
CRYZ crystallin, zeta (quinone reductase) -3.24318
CDC45 cell division cycle 45 -3.22673
CD44 CD44 molecule (Indian blood group) -3.03035
RNF167 ring finger protein 167 -2.92825
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.84403
COG2 component of oligomeric golgi complex 2 -2.83841
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.80375
POLR1G RNA polymerase I subunit G -2.60387
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -2.50328
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae) -2.46589
CDCA4 cell division cycle associated 4 -2.42132
MSMO1 methylsterol monooxygenase 1 -2.37423
IGFBP7 insulin-like growth factor binding protein 7 -2.35848
FANCC Fanconi anemia, complementation group C -2.35838
NCAPH non-SMC condensin I complex, subunit H -2.35735
CDC25A cell division cycle 25A -2.33206
MCM3 minichromosome maintenance complex component 3 -2.33177
GMNN geminin, DNA replication inhibitor -2.31953
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -2.27251
EXO1 exonuclease 1 -2.26323
CDC7 cell division cycle 7 -2.23238
PPY pancreatic polypeptide -2.22753
STEAP1B STEAP family member 1B -2.2093
MTERF3 mitochondrial transcription termination factor 3 -2.18767
PAEP progestagen-associated endometrial protein -2.17994
SPRY4 sprouty homolog 4 (Drosophila) -2.15567
NUP85 nucleoporin 85kDa -2.14969
GINS3 GINS complex subunit 3 (Psf3 homolog) -2.12758
TEDC2 tubulin epsilon and delta complex 2 -2.105
MCM6 minichromosome maintenance complex component 6 -2.10148
STXBP2 syntaxin binding protein 2 -2.0608
MRGBP MRG/MORF4L binding protein -2.03648
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.01633
NLE1 notchless homolog 1 (Drosophila) -2.01549
MOK MOK protein kinase -2.00176