| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | oxytetracycline.hcl 33.27 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome) |
| Similar Terms | |
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97 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:J08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 5.7043 |
| PYCR1 | pyrroline-5-carboxylate reductase 1 | 5.39664 |
| PHGDH | phosphoglycerate dehydrogenase | 5.2127 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 4.95085 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | 4.75303 |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 | 4.53634 |
| SLC37A4 | solute carrier family 37 (glucose-6-phosphate transporter), member 4 | 4.05608 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | 4.02549 |
| HBA1 | hemoglobin, alpha 1 | 4.00487 |
| PSAT1 | phosphoserine aminotransferase 1 | 3.92692 |
| SLC1A4 | solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 | 3.84344 |
| AARS1 | alanyl-tRNA synthetase 1 | 3.82246 |
| MYLK | myosin light chain kinase | 3.4938 |
| SHMT2 | serine hydroxymethyltransferase 2 (mitochondrial) | 3.02943 |
| WIF1 | WNT inhibitory factor 1 | 2.95594 |
| ATP11B | ATPase, class VI, type 11B | 2.86991 |
| CARS1 | cysteinyl-tRNA synthetase 1 | 2.70853 |
| TRIB3 | tribbles pseudokinase 3 | 2.67467 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 2.64762 |
| MARS1 | methionyl-tRNA synthetase 1 | 2.59565 |
| CADM1 | cell adhesion molecule 1 | 2.58559 |
| SLC1A5 | solute carrier family 1 (neutral amino acid transporter), member 5 | 2.56341 |
| SLC3A2 | solute carrier family 3 (amino acid transporter heavy chain), member 2 | 2.56011 |
| SARS1 | seryl-tRNA synthetase 1 | 2.55327 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 2.46171 |
| DECR1 | 2,4-dienoyl CoA reductase 1, mitochondrial | 2.44405 |
| EGR1 | early growth response 1 | 2.35305 |
| ATF4 | activating transcription factor 4 | 2.34808 |
| GARS1 | glycyl-tRNA synthetase 1 | 2.29569 |
| LOC102724560 | cystathionine beta-synthase | 2.29107 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 2.26583 |
| ASH2L | ash2 (absent, small, or homeotic)-like (Drosophila) | 2.25571 |
| ARL2 | ADP-ribosylation factor-like 2 | 2.22889 |
| PIGF | phosphatidylinositol glycan anchor biosynthesis, class F | 2.21529 |
| NLRP4 | NLR family, pyrin domain containing 4 | 2.21251 |
| CHMP4B | charged multivesicular body protein 4B | 2.20047 |
| DDIT4 | DNA-damage-inducible transcript 4 | 2.19622 |
| ADSL | adenylosuccinate lyase | 2.18719 |
| EIF2D | eukaryotic translation initiation factor 2D | 2.15326 |
| RBKS | ribokinase | 2.1375 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 2.1142 |
| NDUFB5 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa | 2.05623 |
| CD82 | CD82 molecule | 2.05591 |
| GDF5 | growth differentiation factor 5 | 2.05546 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 2.04942 |
| XPOT | exportin, tRNA | 2.0262 |
| AGR2 | anterior gradient 2 | 2.01712 |
| THYN1 | thymocyte nuclear protein 1 | 2.01024 |
| Symbol | Name | Standardized Value |
|---|---|---|
| THAP11 | THAP domain containing 11 | -6.13483 |
| BAG3 | BCL2-associated athanogene 3 | -4.68572 |
| CYCS | cytochrome c, somatic | -3.75362 |
| MRPS2 | mitochondrial ribosomal protein S2 | -3.74568 |
| DIPK1A | divergent protein kinase domain 1A | -3.73563 |
| UFM1 | ubiquitin-fold modifier 1 | -3.59829 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -3.33004 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -3.27748 |
| TCTA | T-cell leukemia translocation altered | -3.26466 |
| ANXA2 | annexin A2 | -3.20217 |
| TLE1 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) | -3.14677 |
| POLR2I | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa | -3.02342 |
| TRAPPC3 | trafficking protein particle complex 3 | -2.9609 |
| SLC2A6 | solute carrier family 2 (facilitated glucose transporter), member 6 | -2.94688 |
| UBA1 | ubiquitin-like modifier activating enzyme 1 | -2.94093 |
| NELFB | negative elongation factor complex member B | -2.89947 |
| COG7 | component of oligomeric golgi complex 7 | -2.80042 |
| FUBP3 | far upstream element (FUSE) binding protein 3 | -2.78233 |
| PIERCE1 | piercer of microtubule wall 1 | -2.77372 |
| MAP7D1 | MAP7 domain containing 1 | -2.64589 |
| WDR44 | WD repeat domain 44 | -2.58618 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | -2.57979 |
| UQCR10 | ubiquinol-cytochrome c reductase, complex III subunit X | -2.577 |
| EDC4 | enhancer of mRNA decapping 4 | -2.40926 |
| ODF2 | outer dense fiber of sperm tails 2 | -2.40902 |
| PUDP | pseudouridine 5'-phosphatase | -2.40647 |
| TIMCC | TIM double twin CX3C motif chaperone | -2.40047 |
| SMNDC1 | survival motor neuron domain containing 1 | -2.38634 |
| RAB9A | RAB9A, member RAS oncogene family | -2.37079 |
| ENDOG | endonuclease G | -2.36919 |
| LZTFL1 | leucine zipper transcription factor-like 1 | -2.32259 |
| BBOF1 | basal body orientation factor 1 | -2.3201 |
| ELAC2 | elaC ribonuclease Z 2 | -2.30146 |
| PPP1R26 | protein phosphatase 1, regulatory subunit 26 | -2.27403 |
| JUND | jun D proto-oncogene | -2.26715 |
| TICAM1 | toll-like receptor adaptor molecule 1 | -2.26062 |
| INSIG1 | insulin induced gene 1 | -2.25816 |
| COQ4 | coenzyme Q4 | -2.25593 |
| MRPS15 | mitochondrial ribosomal protein S15 | -2.22021 |
| PFN1 | profilin 1 | -2.21865 |
| NUS1 | nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) | -2.21473 |
| ANAPC2 | anaphase promoting complex subunit 2 | -2.19819 |
| GTF3C4 | general transcription factor IIIC, polypeptide 4, 90kDa | -2.12322 |
| TPPP3 | tubulin polymerization-promoting protein family member 3 | -2.11539 |
| DNTTIP2 | deoxynucleotidyltransferase, terminal, interacting protein 2 | -2.08162 |
| NUDT19 | nudix (nucleoside diphosphate linked moiety X)-type motif 19 | -2.06944 |
| HSPB1 | heat shock 27kDa protein 1 | -2.0678 |
| COX6B1 | cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) | -2.03464 |
| SURF2 | surfeit 2 | -2.02575 |
