CRCGN017_MCF10A.TP53.M_24H:J10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description caprolactam 99.8 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

57 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:J10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 4.66275
TOMM34 translocase of outer mitochondrial membrane 34 4.61035
MAMLD1 mastermind-like domain containing 1 4.4905
INTS3 integrator complex subunit 3 4.4424
SQOR sulfide quinone oxidoreductase 4.0874
ACAA1 acetyl-CoA acyltransferase 1 3.72327
CRELD2 cysteine-rich with EGF-like domains 2 3.0722
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 2.60015
ATG7 autophagy related 7 2.36385
CRBN cereblon 2.20075
TCEA2 transcription elongation factor A (SII), 2 2.18715
SLC75A1 solute carrier family 75 member 1 2.0814
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) 2.0764
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 2.0509
TYK2 tyrosine kinase 2 2.04845
CRIPT cysteine-rich PDZ-binding protein 2.044

decreased expression

Symbol Name Standardized Value
ISOC1 isochorismatase domain containing 1 -5.2816
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.13225
KRT14 keratin 14, type I -4.72715
KBTBD2 kelch repeat and BTB (POZ) domain containing 2 -3.5575
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.37605
ZMYM2 zinc finger, MYM-type 2 -2.97737
CLTB clathrin, light chain B -2.92316
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 -2.7639
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.71365
RPP38 ribonuclease P/MRP 38kDa subunit -2.70775
MACF1 microtubule-actin crosslinking factor 1 -2.58437
MTERF3 mitochondrial transcription termination factor 3 -2.48185
LORICRIN loricrin cornified envelope precursor protein -2.47415
ZNF217 zinc finger protein 217 -2.4383
CALML4 calmodulin-like 4 -2.42732
PLEKHS1 pleckstrin homology domain containing, family S member 1 -2.3573
DPY19L1 dpy-19-like 1 (C. elegans) -2.3286
FKBP9 FK506 binding protein 9, 63 kDa -2.29335
IGFBP7 insulin-like growth factor binding protein 7 -2.28452
GRHL2 grainyhead-like 2 (Drosophila) -2.27745
DSG1 desmoglein 1 -2.23885
FLG filaggrin -2.2207
ALOX12B arachidonate 12-lipoxygenase, 12R type -2.21815
FAM234B family with sequence similarity 234 member B -2.20825
KRT1 keratin 1, type II -2.1855
CDH5 cadherin 5, type 2 (vascular endothelium) -2.18155
ZMPSTE24 zinc metallopeptidase STE24 -2.14775
AVL9 AVL9 homolog (S. cerevisiase) -2.1415
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2 -2.11325
LCE2B late cornified envelope 2B -2.1019
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) -2.09478
LOC124906748 beta-defensin 4A -2.0843
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) -2.0823
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic) -2.07422
SNRPE small nuclear ribonucleoprotein polypeptide E -2.0574
SP3 Sp3 transcription factor -2.03435
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G -2.031
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) -2.03075
KRT2 keratin 2, type II -2.024
TEC tec protein tyrosine kinase -2.0164
COXFA4L2 cytochrome c oxidase hypoxia associated subunit FA4L2 -2.0078