CRCGN017_MCF10A.TP53.M_24H:J11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description caprolactam 33.27 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

42 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:J11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ACAA1 acetyl-CoA acyltransferase 1 5.74433
AMDHD2 amidohydrolase domain containing 2 5.38018
TBX2 T-box 2 5.00019
KDM5A lysine (K)-specific demethylase 5A 4.68301
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.56868
AGR2 anterior gradient 2 2.9725
CDCA4 cell division cycle associated 4 2.85908
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 2.72553
MTA2 metastasis associated 1 family, member 2 2.58187
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 2.55917
SNAP25 synaptosomal-associated protein, 25kDa 2.55135
E2F2 E2F transcription factor 2 2.54885
GALK1 galactokinase 1 2.54095
U2AF2 U2 small nuclear RNA auxiliary factor 2 2.49559
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.47706
WIF1 WNT inhibitory factor 1 2.4451
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.37144
TARBP2 TAR (HIV-1) RNA binding protein 2 2.34292
GPHRA golgi pH regulator A 2.29116
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 2.2577
BCAS3 breast carcinoma amplified sequence 3 2.21798
RAB3D RAB3D, member RAS oncogene family 2.19847
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 2.15817
CADM4 cell adhesion molecule 4 2.14467
GZMM granzyme M (lymphocyte met-ase 1) 2.12888
RAB31 RAB31, member RAS oncogene family 2.10103
GLRX5 glutaredoxin 5 2.07875
CLDN9 claudin 9 2.07751
DENND2D DENN/MADD domain containing 2D 2.05391
GNRH2 gonadotropin-releasing hormone 2 2.03184
TBC1D31 TBC1 domain family, member 31 2.03079
ZBTB32 zinc finger and BTB domain containing 32 2.02885

decreased expression

Symbol Name Standardized Value
MSN moesin -3.6034
TXLNA taxilin alpha -3.22371
THAP11 THAP domain containing 11 -2.57546
CAB39 calcium binding protein 39 -2.21248
CSNK1A1 casein kinase 1, alpha 1 -2.15472
BID BH3 interacting domain death agonist -2.08228
NUP93 nucleoporin 93kDa -2.07932
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -2.03519
KLHL21 kelch-like family member 21 -2.00882
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -2.00368