CRCGN017_MCF10A.TP53.M_24H:J12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description caprolactam 11.09 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

36 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:J12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 5.03995
SMIM40 small integral membrane protein 40 4.79567
ADO 2-aminoethanethiol (cysteamine) dioxygenase 4.54212
LAGE3 L antigen family, member 3 3.83245
KDM5D lysine (K)-specific demethylase 5D 3.40483
EPHB2 EPH receptor B2 2.96362
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 2.92061
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.74672
TBX2 T-box 2 2.353
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 2.3467
EDN1 endothelin 1 2.26017
TRAPPC4 trafficking protein particle complex 4 2.1705
HBA1 hemoglobin, alpha 1 2.1057
CCL22 chemokine (C-C motif) ligand 22 2.07201
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2 2.04855
SETD3 SET domain containing 3 2.04595
USP9Y ubiquitin specific peptidase 9, Y-linked 2.00575

decreased expression

Symbol Name Standardized Value
LAP3 leucine aminopeptidase 3 -4.95029
UFM1 ubiquitin-fold modifier 1 -4.22451
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -3.20155
PFN1 profilin 1 -3.19732
PSIP1 PC4 and SFRS1 interacting protein 1 -3.05785
KDM5C lysine (K)-specific demethylase 5C -2.96886
THAP11 THAP domain containing 11 -2.6942
MTERF3 mitochondrial transcription termination factor 3 -2.58242
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 -2.57084
THOC1 THO complex 1 -2.45519
TRIB3 tribbles pseudokinase 3 -2.4407
LOC124905557 eukaryotic translation initiation factor 1A, X-chromosomal -2.32107
IL33 interleukin 33 -2.17823
NLRP1 NLR family, pyrin domain containing 1 -2.17366
PUDP pseudouridine 5'-phosphatase -2.16571
MSN moesin -2.11134
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -2.08639
PPIB peptidylprolyl isomerase B (cyclophilin B) -2.08296
GYG2 glycogenin 2 -2.00442