CRCGN017_MCF10A.TP53.M_24H:J14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

43 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:J14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
FKBP14 FK506 binding protein 14, 22 kDa 4.4387
ADGRE5 adhesion G protein-coupled receptor E5 4.36253
MAMLD1 mastermind-like domain containing 1 4.25714
SSBP2 single-stranded DNA binding protein 2 4.02272
CIAO3 cytosolic iron-sulfur assembly component 3 3.97865
CNRIP1 cannabinoid receptor interacting protein 1 3.62382
CXCR4 chemokine (C-X-C motif) receptor 4 3.5696
ACAA1 acetyl-CoA acyltransferase 1 3.52325
SNAP25 synaptosomal-associated protein, 25kDa 3.46633
SATB1 SATB homeobox 1 3.1718
GRB10 growth factor receptor-bound protein 10 3.03247
FAM171A1 family with sequence similarity 171, member A1 2.80826
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2.78314
COBL cordon-bleu WH2 repeat protein 2.74476
SNCA synuclein, alpha (non A4 component of amyloid precursor) 2.70907
SMAD5 SMAD family member 5 2.491
SEC13 SEC13 homolog (S. cerevisiae) 2.48102
MYO5C myosin VC 2.43584
TMEM186 transmembrane protein 186 2.30321
ANKRD28 ankyrin repeat domain 28 2.20162
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 2.19346
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.18242
ELSPBP1 epididymal sperm binding protein 1 2.11632
GRAMD1B GRAM domain containing 1B 2.05931
INKA2 inka box actin regulator 2 2.05233
ELOVL6 ELOVL fatty acid elongase 6 2.0162

decreased expression

Symbol Name Standardized Value
TOR1A torsin family 1, member A (torsin A) -5.88036
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.84809
RPIA ribose 5-phosphate isomerase A -4.14098
CDC25B cell division cycle 25B -3.76625
CDC45 cell division cycle 45 -3.56368
APIP APAF1 interacting protein -3.20244
RBM34 RNA binding motif protein 34 -2.88194
CORO1A coronin, actin binding protein, 1A -2.80065
CXCL14 chemokine (C-X-C motif) ligand 14 -2.48998
BCOR BCL6 corepressor -2.44606
C1QA complement component 1, q subcomponent, A chain -2.43056
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1 -2.21875
ATP11B ATPase, class VI, type 11B -2.09078
LY96 lymphocyte antigen 96 -2.06446
KIZ kizuna centrosomal protein -2.04742
NAT10 N-acetyltransferase 10 (GCN5-related) -2.04223
TOR1B torsin family 1, member B (torsin B) -2.00849