CRCGN017_MCF10A.TP53.M_24H:J19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4-acetylaminobiphenyl 100.52 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

49 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:J19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SPAG4 sperm associated antigen 4 5.43306
AGR2 anterior gradient 2 5.12199
CCDC92 coiled-coil domain containing 92 4.95317
WASF3 WAS protein family, member 3 4.56824
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.24839
MCOLN1 mucolipin 1 3.17749
DENND2D DENN/MADD domain containing 2D 3.07818
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.01345
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) 2.94715
COMP cartilage oligomeric matrix protein 2.768
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 2.75392
CLNS1A chloride channel, nucleotide-sensitive, 1A 2.67535
SESN1 sestrin 1 2.46168
THAP12 THAP domain containing 12 2.42999
HBB hemoglobin, beta 2.37044
AAMDC adipogenesis associated, Mth938 domain containing 2.25265
SH3YL1 SH3 and SYLF domain containing 1 2.19624
NUTF2 nuclear transport factor 2 2.18828
OSTF1 osteoclast stimulating factor 1 2.11463
RSF1 remodeling and spacing factor 1 2.05022
CNPY3 canopy FGF signaling regulator 3 2.02064

decreased expression

Symbol Name Standardized Value
NUP85 nucleoporin 85kDa -4.97254
TES testin LIM domain protein -4.85078
BASP1 brain abundant, membrane attached signal protein 1 -4.82308
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -4.36997
KRT14 keratin 14, type I -3.55378
GDF15 growth differentiation factor 15 -3.42464
NRIP1 nuclear receptor interacting protein 1 -3.3387
MRPL58 mitochondrial ribosomal protein L58 -3.11937
MRPS7 mitochondrial ribosomal protein S7 -3.10932
HEATR1 HEAT repeat containing 1 -2.96014
TBCB tubulin folding cofactor B -2.91763
SAP30BP SAP30 binding protein -2.91556
BID BH3 interacting domain death agonist -2.84467
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -2.79223
KCTD2 potassium channel tetramerization domain containing 2 -2.77879
SUMO4 small ubiquitin-like modifier 4 -2.75602
GRB2 growth factor receptor-bound protein 2 -2.61883
ANKRD27 ankyrin repeat domain 27 (VPS9 domain) -2.59815
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.52395
CDR2L cerebellar degeneration-related protein 2-like -2.45681
KDM3A lysine (K)-specific demethylase 3A -2.42699
JPT1 Jupiter microtubule associated homolog 1 -2.26439
GMEB2 glucocorticoid modulatory element binding protein 2 -2.21267
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -2.20624
AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 -2.18681
CERS1 ceramide synthase 1 -2.1734
PCCB propionyl CoA carboxylase, beta polypeptide -2.17178
LLGL2 lethal giant larvae homolog 2 (Drosophila) -2.09474