CRCGN017_MCF10A.TP53.M_24H:J22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description pregnenolone 104.17 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

25 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:J22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 3.39841
ADO 2-aminoethanethiol (cysteamine) dioxygenase 3.34048
SSBP2 single-stranded DNA binding protein 2 2.97692
HBA1 hemoglobin, alpha 1 2.81491
FGFR4 fibroblast growth factor receptor 4 2.71855
C2CD2 C2 calcium-dependent domain containing 2 2.67935
EPHB2 EPH receptor B2 2.51065
RAB21 RAB21, member RAS oncogene family 2.49318
NUCB2 nucleobindin 2 2.34168
CCDC85B coiled-coil domain containing 85B 2.23082
COMP cartilage oligomeric matrix protein 2.16919
GSTZ1 glutathione S-transferase zeta 1 2.13284
CNPY3 canopy FGF signaling regulator 3 2.07714
EPB41L4B erythrocyte membrane protein band 4.1 like 4B 2.03901
NRBF2 nuclear receptor binding factor 2 2.02803

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.78443
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide -3.4796
ANKRD10 ankyrin repeat domain 10 -3.44331
OXA1L oxidase (cytochrome c) assembly 1-like -3.4198
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.72436
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.43575
LETMD1 LETM1 domain containing 1 -2.42054
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.13893
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 -2.06244
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.03258