CRCGN017_MCF10A.TP53.M_24H:J24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description pregnenolone 11.57 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

66 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:J24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SNAP25 synaptosomal-associated protein, 25kDa 8.35608
STMN2 stathmin 2 4.72952
CCP110 centriolar coiled coil protein 110kDa 3.76655
NSG2 neuronal vesicle trafficking associated 2 3.75727
AGR2 anterior gradient 2 3.56764
NEFM neurofilament, medium polypeptide 3.40733
SYT1 synaptotagmin I 3.3396
OLFM1 olfactomedin 1 3.27431
SV2B synaptic vesicle glycoprotein 2B 3.27093
NEFH neurofilament, heavy polypeptide 3.25092
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 3.23328
GNG3 guanine nucleotide binding protein (G protein), gamma 3 3.01144
GPER1 G protein-coupled estrogen receptor 1 2.97031
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 2.95551
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 2.78858
NEFL neurofilament, light polypeptide 2.76769
SYN1 synapsin I 2.76732
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 2.76384
CARTPT CART prepropeptide 2.71373
SNAP91 synaptosomal-associated protein, 91kDa 2.70819
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 2.68138
TAGLN3 transgelin 3 2.67322
RPH3A rabphilin 3A 2.67261
SH3GL2 SH3-domain GRB2-like 2 2.61296
NMNAT2 nicotinamide nucleotide adenylyltransferase 2 2.59117
NPTX1 neuronal pentraxin I 2.58889
CHGB chromogranin B 2.52643
VSNL1 visinin-like 1 2.49909
SULT4A1 sulfotransferase family 4A, member 1 2.49885
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 2.46084
ELAVL4 ELAV like neuron-specific RNA binding protein 4 2.3792
TAC1 tachykinin, precursor 1 2.34869
LGI1 leucine-rich, glioma inactivated 1 2.31766
NSF N-ethylmaleimide-sensitive factor 2.30632
SNCB synuclein, beta 2.2576
INA internexin neuronal intermediate filament protein, alpha 2.24453
SV2C synaptic vesicle glycoprotein 2C 2.22673
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 2.21682
RUNDC3A RUN domain containing 3A 2.19519
SPECC1L sperm antigen with calponin homology and coiled-coil domains 1-like 2.17175
DIRAS2 DIRAS family, GTP-binding RAS-like 2 2.11216
ZIC1 Zic family member 1 2.07823
SYP synaptophysin 2.05892
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 2.04502
ACTL6B actin-like 6B 2.02992
PDYN prodynorphin 2.02255
IFT57 intraflagellar transport 57 2.0166
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.00525

decreased expression

Symbol Name Standardized Value
KDM3A lysine (K)-specific demethylase 3A -3.5315
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.27492
PIH1D1 PIH1 domain containing 1 -3.23808
JMJD6 jumonji domain containing 6 -3.08726
CYCS cytochrome c, somatic -3.06659
NSDHL NAD(P) dependent steroid dehydrogenase-like -3.06173
CD81 CD81 molecule -2.761
THAP11 THAP domain containing 11 -2.65699
MSMO1 methylsterol monooxygenase 1 -2.59422
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.41632
RRAGD Ras-related GTP binding D -2.31947
VPREB1 pre-B lymphocyte 1 -2.1267
CBR3 carbonyl reductase 3 -2.12262
LIN37 lin-37 DREAM MuvB core complex component -2.12165
CETN2 centrin, EF-hand protein, 2 -2.09129
NMRK2 nicotinamide riboside kinase 2 -2.07895
SEC61G Sec61 gamma subunit -2.06517
DNASE1L1 deoxyribonuclease I-like 1 -2.01244