CRCGN017_MCF10A.TP53.M_24H:K01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description edaravone 100.3 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

87 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:K01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.30505
CXCL2 chemokine (C-X-C motif) ligand 2 4.38885
FGFR4 fibroblast growth factor receptor 4 4.04833
GRB10 growth factor receptor-bound protein 10 3.60003
ACAA1 acetyl-CoA acyltransferase 1 3.10753
RHCG Rh family, C glycoprotein 2.46895
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) 2.41385
CAPN1 calpain 1, (mu/I) large subunit 2.35755
AOPEP aminopeptidase O (putative) 2.27195
DENND10 DENN domain containing 10 2.2028
TBC1D31 TBC1 domain family, member 31 2.15715
CRNN cornulin 2.14825
BIK BCL2-interacting killer (apoptosis-inducing) 2.1414
DTX2 deltex 2, E3 ubiquitin ligase 2.12845
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa 2.11605
PARL presenilin associated, rhomboid-like 2.10285
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide 2.0715
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.0413
AAR2 AAR2 splicing factor homolog (S. cerevisiae) 2.0348
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 2.01755

decreased expression

Symbol Name Standardized Value
LYPLA1 lysophospholipase I -4.71705
HMG20B high mobility group 20B -3.9488
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -3.83777
NR2F6 nuclear receptor subfamily 2, group F, member 6 -3.53082
CD226 CD226 molecule -2.8799
MRPL15 mitochondrial ribosomal protein L15 -2.86915
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.86577
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -2.85015
OCEL1 occludin/ELL domain containing 1 -2.8148
LRP1B low density lipoprotein receptor-related protein 1B -2.8051
RFX4 regulatory factor X, 4 (influences HLA class II expression) -2.8015
LYPLA1-TCEA1 LYPLA1-TCEA1 readthrough -2.72715
EPCIP exosomal polycystin 1 interacting protein -2.7128
SLCO1C1 solute carrier organic anion transporter family, member 1C1 -2.6448
KLHL26 kelch-like family member 26 -2.64135
NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 -2.6276
BABAM1 BRISC and BRCA1 A complex member 1 -2.57635
KDM3A lysine (K)-specific demethylase 3A -2.55375
NT5DC2 5'-nucleotidase domain containing 2 -2.5535
ADGRB3 adhesion G protein-coupled receptor B3 -2.48405
TOX thymocyte selection-associated high mobility group box -2.47965
GDF10 growth differentiation factor 10 -2.4686
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -2.40873
HNF4G hepatocyte nuclear factor 4, gamma -2.37255
MBNL3 muscleblind-like splicing regulator 3 -2.33655
SCG3 secretogranin III -2.3145
CCDC102B coiled-coil domain containing 102B -2.2581
DIRAS2 DIRAS family, GTP-binding RAS-like 2 -2.25135
CDH10 cadherin 10, type 2 (T2-cadherin) -2.24465
NR2E1 nuclear receptor subfamily 2, group E, member 1 -2.23735
CCDC181 coiled-coil domain containing 181 -2.23725
PRDM5 PR domain containing 5 -2.2299
TDRD1 tudor domain containing 1 -2.22645
LORICRIN loricrin cornified envelope precursor protein -2.2174
KLF10 Kruppel-like factor 10 -2.20985
SP4 Sp4 transcription factor -2.20415
DIAPH3 diaphanous-related formin 3 -2.1993
PDE3A phosphodiesterase 3A, cGMP-inhibited -2.1729
F2RL2 coagulation factor II (thrombin) receptor-like 2 -2.16295
IKZF2 IKAROS family zinc finger 2 (Helios) -2.1556
TBR1 T-box, brain, 1 -2.14075
FGF14 fibroblast growth factor 14 -2.11795
SCG2 secretogranin II -2.1179
PTPRK protein tyrosine phosphatase, receptor type, K -2.1144
CNGA3 cyclic nucleotide gated channel alpha 3 -2.11285
EDDM3B epididymal protein 3B -2.1118
SCAI suppressor of cancer cell invasion -2.11145
NLGN4Y neuroligin 4, Y-linked -2.1043
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 -2.0969
NOL4 nucleolar protein 4 -2.0869
CNTN6 contactin 6 -2.06965
ELOVL2 ELOVL fatty acid elongase 2 -2.06833
SYTL3 synaptotagmin-like 3 -2.05805
KALRN kalirin, RhoGEF kinase -2.04877
GTPBP3 GTP binding protein 3 (mitochondrial) -2.04405
MAPK10 mitogen-activated protein kinase 10 -2.03915
NRCAM neuronal cell adhesion molecule -2.03872
TSBP1 testis expressed basic protein 1 -2.0364
SPATA6L spermatogenesis associated 6-like -2.0351
UBE2W ubiquitin-conjugating enzyme E2W (putative) -2.0331
DAPK1 death-associated protein kinase 1 -2.03175
PRKCQ protein kinase C, theta -2.02927
TGFB3 transforming growth factor, beta 3 -2.0287
SCAPER S-phase cyclin A-associated protein in the ER -2.02445
PALS2 protein associated with LIN7 2, MAGUK p55 family member -2.01805
MEX3C mex-3 RNA binding family member C -2.0081
CTAGE1 cutaneous T-cell lymphoma-associated antigen 1 -2.0031