CRCGN017_MCF10A.TP53.M_24H:K06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description glutaraldehyde 10.76 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

48 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:K06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HMOX1 heme oxygenase 1 5.78941
TSEN2 TSEN2 tRNA splicing endonuclease subunit 4.01068
AAMDC adipogenesis associated, Mth938 domain containing 3.32212
KIF5C kinesin family member 5C 3.1094
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.81919
NMRK2 nicotinamide riboside kinase 2 2.5604
CLNS1A chloride channel, nucleotide-sensitive, 1A 2.45193
TUBB4B tubulin, beta 4B class IVb 2.43582
MOK MOK protein kinase 2.38976
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.37858
CASP6 caspase 6, apoptosis-related cysteine peptidase 2.35148
PKN1 protein kinase N1 2.32191
CGRRF1 cell growth regulator with ring finger domain 1 2.30695
SOD1 superoxide dismutase 1, soluble 2.27248
DCAF6 DDB1 and CUL4 associated factor 6 2.25682
F8 coagulation factor VIII, procoagulant component 2.18375
PECR peroxisomal trans-2-enoyl-CoA reductase 2.12457
CD9 CD9 molecule 2.11778
EMSY EMSY transcriptional repressor, BRCA2 interacting 2.10958
UBA1 ubiquitin-like modifier activating enzyme 1 2.10691
PCYOX1 prenylcysteine oxidase 1 2.06198
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 2.00957

decreased expression

Symbol Name Standardized Value
MSMO1 methylsterol monooxygenase 1 -4.72792
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -4.17718
RNF167 ring finger protein 167 -3.60424
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.45423
CIAPIN1 cytokine induced apoptosis inhibitor 1 -3.24587
ATG3 autophagy related 3 -2.83513
ZNHIT6 zinc finger, HIT-type containing 6 -2.66922
THAP11 THAP domain containing 11 -2.58053
TOMM70 translocase of outer mitochondrial membrane 70 -2.42093
TIMELESS timeless circadian clock -2.30607
VNN2 vanin 2 -2.23627
TRIB3 tribbles pseudokinase 3 -2.22057
UBIAD1 UbiA prenyltransferase domain containing 1 -2.12463
ANKRD55 ankyrin repeat domain 55 -2.09803
CLCC1 chloride channel CLIC-like 1 -2.09723
CTLA4 cytotoxic T-lymphocyte-associated protein 4 -2.07195
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 -2.05737
IL21 interleukin 21 -2.04486
HHEX hematopoietically expressed homeobox -2.04339
ZNF528 zinc finger protein 528 -2.03651
SMAD9 SMAD family member 9 -2.02472
PCDH17 protocadherin 17 -2.0182
TWNK twinkle mtDNA helicase -2.01682
GRWD1 glutamate-rich WD repeat containing 1 -2.00915
MEFV Mediterranean fever -2.00213
ZNF280A zinc finger protein 280A -2.00048