CRCGN017_MCF10A.TP53.M_24H:K10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description wortmannin 10.0 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

676 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:K10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCL2 chemokine (C-X-C motif) ligand 2 7.22615
IL1B interleukin 1, beta 6.69155
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 5.50495
SQOR sulfide quinone oxidoreductase 5.47345
TNIP1 TNFAIP3 interacting protein 1 5.24015
ADAM10 ADAM metallopeptidase domain 10 5.17515
MYL9 myosin, light chain 9, regulatory 5.12485
TSEN2 TSEN2 tRNA splicing endonuclease subunit 5.05425
UBQLN2 ubiquilin 2 4.52475
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 4.4308
TPM1 tropomyosin 1 (alpha) 4.42931
AVEN apoptosis, caspase activation inhibitor 4.4123
SPAG4 sperm associated antigen 4 4.20005
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 3.9928
VAT1 vesicle amine transport 1 3.9354
FAT1 FAT atypical cadherin 1 3.8527
MINDY2 MINDY lysine 48 deubiquitinase 2 3.6003
FCHO1 FCH domain only 1 3.56775
IL1A interleukin 1, alpha 3.5379
BAMBI BMP and activin membrane-bound inhibitor 3.4299
GRN granulin 3.42158
FHL2 four and a half LIM domains 2 3.3579
PACS2 phosphofurin acidic cluster sorting protein 2 3.24498
PARP12 poly (ADP-ribose) polymerase family, member 12 3.11875
SPINT1 serine peptidase inhibitor, Kunitz type 1 3.0982
RNF44 ring finger protein 44 3.09025
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.0824
KLF11 Kruppel-like factor 11 3.07665
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 3.06275
ZC3H12A zinc finger CCCH-type containing 12A 3.0507
PTHLH parathyroid hormone-like hormone 3.03852
MEAK7 MTOR associated protein, eak-7 homolog 3.0366
ITFG1 integrin alpha FG-GAP repeat containing 1 3.02295
AMIGO2 adhesion molecule with Ig-like domain 2 2.9945
MMP1 matrix metallopeptidase 1 2.97322
SREK1IP1 SREK1-interacting protein 1 2.95
CXCL3 chemokine (C-X-C motif) ligand 3 2.9295
MYH9 myosin, heavy chain 9, non-muscle 2.9045
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.9001
INA internexin neuronal intermediate filament protein, alpha 2.84725
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 2.83555
MSRA methionine sulfoxide reductase A 2.80255
INF2 inverted formin, FH2 and WH2 domain containing 2.7963
FSD1 fibronectin type III and SPRY domain containing 1 2.7954
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.7846
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 2.76405
ELMO1 engulfment and cell motility 1 2.7627
APOL1 apolipoprotein L, 1 2.7491
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.7322
PDE9A phosphodiesterase 9A 2.7087
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase 2.7083
KLHDC2 kelch domain containing 2 2.6926
PGAP4 post-GPI attachment to proteins GalNAc transferase 4 2.6775
NOP53 NOP53 ribosome biogenesis factor 2.65775
NCF1 neutrophil cytosolic factor 1 2.65465
MOCS1 molybdenum cofactor synthesis 1 2.65272
NUAK2 NUAK family, SNF1-like kinase, 2 2.64255
ZBED2 zinc finger, BED-type containing 2 2.64155
NT5E 5'-nucleotidase, ecto (CD73) 2.6381
TP53BP2 tumor protein p53 binding protein 2 2.6371
IL4R interleukin 4 receptor 2.63585
PMM2 phosphomannomutase 2 2.63555
TGFB1I1 transforming growth factor beta 1 induced transcript 1 2.62935
CTSA cathepsin A 2.6249
IRF1 interferon regulatory factor 1 2.62165
TNF tumor necrosis factor 2.61055
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 2.59955
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 2.58825
CYB5R3 cytochrome b5 reductase 3 2.58155
IVNS1ABP influenza virus NS1A binding protein 2.5618
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 2.55445
ZNF280D zinc finger protein 280D 2.5407
EIF3L eukaryotic translation initiation factor 3, subunit L 2.54005
EIF3CL eukaryotic translation initiation factor 3, subunit C-like 2.53068
GBP2 guanylate binding protein 2, interferon-inducible 2.5269
ZNF665 zinc finger protein 665 2.525
TOR1A torsin family 1, member A (torsin A) 2.52248
TRIM13 tripartite motif containing 13 2.5166
CRTAC1 cartilage acidic protein 1 2.51573
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1 2.51425
TLR3 toll-like receptor 3 2.51395
ETHE1 ethylmalonic encephalopathy 1 2.51065
BSDC1 BSD domain containing 1 2.51062
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 2.5071
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa 2.50365
CNOT4 CCR4-NOT transcription complex, subunit 4 2.50234
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 2.49862
LRRC61 leucine rich repeat containing 61 2.49775
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.4934
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.4925
NRIP2 nuclear receptor interacting protein 2 2.49235
LGMN legumain 2.4906
RNF111 ring finger protein 111 2.48805
LAMA5 laminin, alpha 5 2.4784
SQSTM1 sequestosome 1 2.47687
SPATA2L spermatogenesis associated 2-like 2.47315
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.4704
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 2.45955
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2 2.45195
PMP22 peripheral myelin protein 22 2.44322
KDM6B lysine (K)-specific demethylase 6B 2.4415
ZNF696 zinc finger protein 696 2.43645
SLCO3A1 solute carrier organic anion transporter family, member 3A1 2.42698
ADIRF adipogenesis regulatory factor 2.4242
CBX7 chromobox homolog 7 2.4194
ELMO3 engulfment and cell motility 3 2.4045
NOTCH1 notch 1 2.39435
ZFHX3 zinc finger homeobox 3 2.39265
CCNG2 cyclin G2 2.39168
TESK1 testis-specific kinase 1 2.3851
TRIB2 tribbles pseudokinase 2 2.3841
PHC1 polyhomeotic homolog 1 (Drosophila) 2.38165
YPEL5 yippee-like 5 (Drosophila) 2.38095
MVP major vault protein 2.37965
RASA2 RAS p21 protein activator 2 2.378
IER5 immediate early response 5 2.37735
TRIB1 tribbles pseudokinase 1 2.37625
JAG2 jagged 2 2.37022
MANBA mannosidase, beta A, lysosomal 2.3672
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 2.3668
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 2.36643
LPGAT1 lysophosphatidylglycerol acyltransferase 1 2.3655
UGDH UDP-glucose 6-dehydrogenase 2.3611
DUSP5 dual specificity phosphatase 5 2.36055
RALGDS ral guanine nucleotide dissociation stimulator 2.35573
H2AC19 H2A clustered histone 19 2.35532
GREM1 gremlin 1, DAN family BMP antagonist 2.3543
KIZ kizuna centrosomal protein 2.34595
LAMC2 laminin, gamma 2 2.34345
DBN1 drebrin 1 2.34115
DENND4A DENN/MADD domain containing 4A 2.33475
CD40 CD40 molecule, TNF receptor superfamily member 5 2.33445
AIDA axin interactor, dorsalization associated 2.3343
ADRB2 adrenoceptor beta 2, surface 2.33375
RPUSD2 RNA pseudouridylate synthase domain containing 2 2.33325
LRFN3 leucine rich repeat and fibronectin type III domain containing 3 2.3331
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.3286
AHNAK2 AHNAK nucleoprotein 2 2.3276
LPCAT4 lysophosphatidylcholine acyltransferase 4 2.32327
TRIM8 tripartite motif containing 8 2.3232
MN1 meningioma (disrupted in balanced translocation) 1 2.31565
OLFML2A olfactomedin-like 2A 2.2969
EHD3 EH-domain containing 3 2.29405
FAM193A family with sequence similarity 193, member A 2.291
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28 2.2887
PCGF3 polycomb group ring finger 3 2.2879
RIGI RNA sensor RIG-I 2.28565
SOX4 SRY (sex determining region Y)-box 4 2.28436
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 2.2805
DGKA diacylglycerol kinase, alpha 80kDa 2.27887
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 2.2773
L1TD1 LINE-1 type transposase domain containing 1 2.277
RAB29 RAB29, member RAS oncogene family 2.27297
MTCL1 microtubule crosslinking factor 1 2.2719
CALCOCO1 calcium binding and coiled-coil domain 1 2.27075
CHN1 chimerin 1 2.26485
DIXDC1 DIX domain containing 1 2.26325
CRELD1 cysteine-rich with EGF-like domains 1 2.26125
CASD1 CAS1 domain containing 1 2.2571
KIAA0930 KIAA0930 2.25413
MACO1 macoilin 1 2.2502
TMCC1 transmembrane and coiled-coil domain family 1 2.24988
DKK3 dickkopf WNT signaling pathway inhibitor 3 2.24923
AOX1 aldehyde oxidase 1 2.24502
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 2.24075
PLEKHS1 pleckstrin homology domain containing, family S member 1 2.23495
SCCPDH saccharopine dehydrogenase (putative) 2.2333
COXFA4L2 cytochrome c oxidase hypoxia associated subunit FA4L2 2.23275
PUDP pseudouridine 5'-phosphatase 2.226
NDRG1 N-myc downstream regulated 1 2.22495
BPGM 2,3-bisphosphoglycerate mutase 2.2242
TLE5 TLE family member 5, transcriptional modulator 2.22285
RAB5B RAB5B, member RAS oncogene family 2.21795
KIAA0040 KIAA0040 2.21585
MX1 MX dynamin-like GTPase 1 2.21455
MMP9 matrix metallopeptidase 9 2.2143
NIPAL2 NIPA-like domain containing 2 2.21225
YIPF3 Yip1 domain family, member 3 2.20585
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1 2.20149
TMEM115 transmembrane protein 115 2.19585
UFC1 ubiquitin-fold modifier conjugating enzyme 1 2.195
HMGA2 high mobility group AT-hook 2 2.195
NME3 NME/NM23 nucleoside diphosphate kinase 3 2.19285
VNN1 vanin 1 2.1912
PTK2B protein tyrosine kinase 2 beta 2.18645
NMNAT2 nicotinamide nucleotide adenylyltransferase 2 2.1858
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 2.1775
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2.17575
EDNRA endothelin receptor type A 2.16993
ZNF395 zinc finger protein 395 2.16805
NHEJ1 nonhomologous end-joining factor 1 2.1631
RAI2 retinoic acid induced 2 2.1627
FAM131B family with sequence similarity 131, member B 2.15905
STBD1 starch binding domain 1 2.15255
EPN2 epsin 2 2.15025
FBXO28 F-box protein 28 2.14357
C1RL complement component 1, r subcomponent-like 2.14195
HSF2BP heat shock transcription factor 2 binding protein 2.1402
CES2 carboxylesterase 2 2.13808
CDCP1 CUB domain containing protein 1 2.13805
CREBL2 cAMP responsive element binding protein-like 2 2.13788
ZNF423 zinc finger protein 423 2.13095
BCOR BCL6 corepressor 2.1286
IPO13 importin 13 2.1275
INHBA inhibin, beta A 2.12733
GPR161 G protein-coupled receptor 161 2.12677
NBEA neurobeachin 2.1256
TAPBPL TAP binding protein-like 2.12447
TCF20 transcription factor 20 (AR1) 2.1224
LAP3 leucine aminopeptidase 3 2.1184
ATP7B ATPase, Cu++ transporting, beta polypeptide 2.11695
MYO1D myosin ID 2.11455
TIMP2 TIMP metallopeptidase inhibitor 2 2.1133
IRF9 interferon regulatory factor 9 2.11205
RNF19B ring finger protein 19B 2.11093
FBXL12 F-box and leucine-rich repeat protein 12 2.10575
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 2.10335
COL7A1 collagen, type VII, alpha 1 2.10075
WDR13 WD repeat domain 13 2.1003
TAL1 T-cell acute lymphocytic leukemia 1 2.0988
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.09748
FRYL FRY-like 2.09365
PBLD phenazine biosynthesis-like protein domain containing 2.0936
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 2.08905
PRKD2 protein kinase D2 2.0886
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 2.08853
EPHX2 epoxide hydrolase 2, cytoplasmic 2.0884
NPDC1 neural proliferation, differentiation and control, 1 2.0865
PANK4 pantothenate kinase 4 2.0834
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent) 2.08312
SNRNP35 small nuclear ribonucleoprotein 35kDa (U11/U12) 2.0767
CXCL11 chemokine (C-X-C motif) ligand 11 2.076
PSEN2 presenilin 2 2.07533
ZNF155 zinc finger protein 155 2.07415
MINPP1 multiple inositol-polyphosphate phosphatase 1 2.07305
PDGFA platelet-derived growth factor alpha polypeptide 2.06978
COL17A1 collagen, type XVII, alpha 1 2.06725
PTCD1 pentatricopeptide repeat domain 1 2.06575
RIPK4 receptor-interacting serine-threonine kinase 4 2.06155
LRP10 low density lipoprotein receptor-related protein 10 2.0613
ZNF112 zinc finger protein 112 2.0606
SYNPO synaptopodin 2.05875
GEMIN8 gem (nuclear organelle) associated protein 8 2.05645
TGFA transforming growth factor, alpha 2.05508
PPOX protoporphyrinogen oxidase 2.05165
THSD7A thrombospondin, type I, domain containing 7A 2.05125
EIF2D eukaryotic translation initiation factor 2D 2.05065
NCSTN nicastrin 2.0482
RHBDF2 rhomboid 5 homolog 2 (Drosophila) 2.04505
TM9SF3 transmembrane 9 superfamily member 3 2.0448
CDIP1 cell death-inducing p53 target 1 2.0432
FNBP1L formin binding protein 1-like 2.04245
GDI1 GDP dissociation inhibitor 1 2.03435
SHFL shiftless antiviral inhibitor of ribosomal frameshifting 2.032
ELF4 E74-like factor 4 (ets domain transcription factor) 2.02647
BDKRB2 bradykinin receptor B2 2.02565
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 2.02295
CCL20 chemokine (C-C motif) ligand 20 2.0219
RNF187 ring finger protein 187 2.0197
CHMP7 charged multivesicular body protein 7 2.0187
DHX30 DEAH (Asp-Glu-Ala-His) box helicase 30 2.01767
ZSCAN9 zinc finger and SCAN domain containing 9 2.01615
PCDHA9 protocadherin alpha 9 2.0144
BIK BCL2-interacting killer (apoptosis-inducing) 2.00995
CEP104 centrosomal protein 104kDa 2.00962
PWP2 PWP2 periodic tryptophan protein homolog (yeast) 2.00905
ROGDI rogdi homolog (Drosophila) 2.00885
MXI1 MAX interactor 1, dimerization protein 2.0085
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 2.00787
KAT2B K(lysine) acetyltransferase 2B 2.0047
PWWP3A PWWP domain containing 3A, DNA repair factor 2.0033
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12 2.00185
CNPY3 canopy FGF signaling regulator 3 2.00165

decreased expression

Symbol Name Standardized Value
UBE2C ubiquitin-conjugating enzyme E2C -9.097
CDC20 cell division cycle 20 -8.2642
PLK1 polo-like kinase 1 -7.96285
KIF20A kinesin family member 20A -7.68395
BIRC5 baculoviral IAP repeat containing 5 -7.53263
CDK1 cyclin-dependent kinase 1 -7.37178
KIF14 kinesin family member 14 -7.1327
CCNB2 cyclin B2 -7.04845
CCNA2 cyclin A2 -7.0276
NUSAP1 nucleolar and spindle associated protein 1 -6.91913
TOP2A topoisomerase (DNA) II alpha 170kDa -6.84853
DEPDC1 DEP domain containing 1 -6.5265
PSRC1 proline/serine-rich coiled-coil 1 -6.5141
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -6.45555
KIF4A kinesin family member 4A -6.1537
HMMR hyaluronan-mediated motility receptor (RHAMM) -6.15063
TXNDC9 thioredoxin domain containing 9 -6.07057
CENPA centromere protein A -5.90677
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -5.7476
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -5.605
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -5.4114
CEP55 centrosomal protein 55kDa -5.4076
TPX2 TPX2, microtubule-associated -5.3972
AURKB aurora kinase B -5.3938
CDKN3 cyclin-dependent kinase inhibitor 3 -5.3775
TTK TTK protein kinase -5.3711
SPC25 SPC25, NDC80 kinetochore complex component -5.1909
PTTG1 pituitary tumor-transforming 1 -5.165
OIP5 Opa interacting protein 5 -5.12155
DDIT4 DNA-damage-inducible transcript 4 -5.0716
PIMREG PICALM interacting mitotic regulator -5.0556
NCAPH non-SMC condensin I complex, subunit H -5.00405
PUF60 poly-U binding splicing factor 60KDa -5.0
KIF11 kinesin family member 11 -4.8509
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -4.80645
CDCA8 cell division cycle associated 8 -4.7994
CDCA3 cell division cycle associated 3 -4.77885
KDM3A lysine (K)-specific demethylase 3A -4.7605
NEK2 NIMA-related kinase 2 -4.6914
CDC25C cell division cycle 25C -4.685
PRC1 protein regulator of cytokinesis 1 -4.6514
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -4.52845
FOXM1 forkhead box M1 -4.4322
TMX2 thioredoxin-related transmembrane protein 2 -4.4274
CCNB1 cyclin B1 -4.42705
NEIL3 nei endonuclease VIII-like 3 (E. coli) -4.2582
STMN1 stathmin 1 -4.25325
RACGAP1 Rac GTPase activating protein 1 -4.25115
SESN1 sestrin 1 -4.1826
SPDL1 spindle apparatus coiled-coil protein 1 -4.17915
SPAG5 sperm associated antigen 5 -4.15425
PARPBP PARP1 binding protein -4.14895
NDC80 NDC80 kinetochore complex component -4.0946
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -4.0635
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -4.0053
CENPE centromere protein E, 312kDa -4.00265
GTF2A2 general transcription factor IIA, 2, 12kDa -3.9973
AURKA aurora kinase A -3.9688
LBR lamin B receptor -3.96725
PARP2 poly (ADP-ribose) polymerase 2 -3.95365
TROAP trophinin associated protein -3.9489
KIFC1 kinesin family member C1 -3.9327
MKI67 marker of proliferation Ki-67 -3.92249
ASF1B anti-silencing function 1B histone chaperone -3.84675
TIMM10 translocase of inner mitochondrial membrane 10 homolog (yeast) -3.845
MRPL58 mitochondrial ribosomal protein L58 -3.84095
TUBA4A tubulin, alpha 4a -3.80245
PBK PDZ binding kinase -3.75095
SHCBP1 SHC SH2-domain binding protein 1 -3.73895
MRPL49 mitochondrial ribosomal protein L49 -3.71105
GTPBP8 GTP-binding protein 8 (putative) -3.69585
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -3.6808
RPA3 replication protein A3, 14kDa -3.67245
SMC4 structural maintenance of chromosomes 4 -3.65893
CCNF cyclin F -3.60402
B4GAT1 beta-1,4-glucuronyltransferase 1 -3.60255
UBE2S ubiquitin-conjugating enzyme E2S -3.55785
TRIP13 thyroid hormone receptor interactor 13 -3.5575
BORA bora, aurora kinase A activator -3.55605
GOLT1B golgi transport 1B -3.54325
HJURP Holliday junction recognition protein -3.52375
KRT10 keratin 10, type I -3.51625
CTNND1 catenin (cadherin-associated protein), delta 1 -3.51315
GEMIN2 gem (nuclear organelle) associated protein 2 -3.48199
DBF4 DBF4 zinc finger -3.4411
TK1 thymidine kinase 1, soluble -3.41145
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 -3.4058
NLRP2B NLR family pyrin domain containing 2B -3.40065
CYCS cytochrome c, somatic -3.39385
COQ2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase -3.38335
CENPN centromere protein N -3.37647
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) -3.37535
EXOSC9 exosome component 9 -3.36215
CMC2 C-x(9)-C motif containing 2 -3.3253
LRRC20 leucine rich repeat containing 20 -3.31425
KIF15 kinesin family member 15 -3.2943
RPP30 ribonuclease P/MRP 30kDa subunit -3.27975
DTYMK deoxythymidylate kinase (thymidylate kinase) -3.2785
KIF18A kinesin family member 18A -3.23595
KIF23 kinesin family member 23 -3.23245
MNAT1 MNAT CDK-activating kinase assembly factor 1 -3.2259
ATAD2 ATPase family, AAA domain containing 2 -3.2243
CHEK2 checkpoint kinase 2 -3.2065
COQ3 coenzyme Q3 methyltransferase -3.1905
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.18272
OXSM 3-oxoacyl-ACP synthase, mitochondrial -3.15885
ADI1 acireductone dioxygenase 1 -3.1553
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit -3.15275
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -3.14925
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -3.1419
CCNC cyclin C -3.1363
CKAP2 cytoskeleton associated protein 2 -3.13325
DCK deoxycytidine kinase -3.12025
COMMD8 COMM domain containing 8 -3.1129
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 -3.1127
TSC22D3 TSC22 domain family, member 3 -3.10792
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 -3.1039
ASF1A anti-silencing function 1A histone chaperone -3.0949
ECD ecdysoneless homolog (Drosophila) -3.09355
MRPL35 mitochondrial ribosomal protein L35 -3.08625
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E -3.08565
FBXO5 F-box protein 5 -3.0685
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -3.0635
TACC3 transforming, acidic coiled-coil containing protein 3 -3.05995
HAT1 histone acetyltransferase 1 -3.0231
MRPL39 mitochondrial ribosomal protein L39 -3.02
EMC9 ER membrane protein complex subunit 9 -2.9946
USP39 ubiquitin specific peptidase 39 -2.989
ZNF274 zinc finger protein 274 -2.98325
ECT2 epithelial cell transforming 2 -2.98135
DDB2 damage-specific DNA binding protein 2, 48kDa -2.97275
MCM10 minichromosome maintenance complex component 10 -2.9515
NCAPD2 non-SMC condensin I complex, subunit D2 -2.94835
SAP30 Sin3A-associated protein, 30kDa -2.9326
MRPS16 mitochondrial ribosomal protein S16 -2.9323
KIF2C kinesin family member 2C -2.92215
CKS1B CDC28 protein kinase regulatory subunit 1B -2.91875
ATP5MC3 ATP synthase membrane subunit c locus 3 -2.90025
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2 -2.88345
SLC25A46 solute carrier family 25, member 46 -2.87465
SLC17A9 solute carrier family 17 (vesicular nucleotide transporter), member 9 -2.86085
ABITRAM actin binding transcription modulator -2.85955
NDUFB3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa -2.8526
LDHD lactate dehydrogenase D -2.8377
CDC45 cell division cycle 45 -2.8368
KHDC4 KH domain containing 4, pre-mRNA splicing factor -2.835
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.8229
CENPU centromere protein U -2.81865
RPL26L1 ribosomal protein L26-like 1 -2.81315
MELK maternal embryonic leucine zipper kinase -2.8067
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -2.798
NCAPG non-SMC condensin I complex, subunit G -2.79617
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 -2.7925
SF3B5 splicing factor 3b, subunit 5, 10kDa -2.78815
CGRRF1 cell growth regulator with ring finger domain 1 -2.78665
LMAN2L lectin, mannose-binding 2-like -2.777
HMGB2 high mobility group box 2 -2.76135
FKBP14 FK506 binding protein 14, 22 kDa -2.76005
VRK1 vaccinia related kinase 1 -2.7519
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase -2.74143
TMEM126B transmembrane protein 126B -2.7347
MRPS22 mitochondrial ribosomal protein S22 -2.71525
MCTS1 malignant T cell amplified sequence 1 -2.71475
KIF20B kinesin family member 20B -2.69782
IPCEF1 interaction protein for cytohesin exchange factors 1 -2.6955
CDC23 cell division cycle 23 -2.6874
MBIP MAP3K12 binding inhibitory protein 1 -2.6846
NAT10 N-acetyltransferase 10 (GCN5-related) -2.68085
RGS2 regulator of G-protein signaling 2 -2.6793
RYR1 ryanodine receptor 1 (skeletal) -2.6696
SSRP1 structure specific recognition protein 1 -2.65843
EPHX3 epoxide hydrolase 3 -2.6563
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -2.65615
RAD51C RAD51 paralog C -2.64748
FKBP10 FK506 binding protein 10, 65 kDa -2.6404
RNASE7 ribonuclease, RNase A family, 7 -2.63908
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.6363
POLA2 polymerase (DNA directed), alpha 2, accessory subunit -2.6345
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) -2.63395
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 -2.62385
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.62285
PLK4 polo-like kinase 4 -2.62132
KIF18B kinesin family member 18B -2.6213
COX7B cytochrome c oxidase subunit VIIb -2.618
CKS2 CDC28 protein kinase regulatory subunit 2 -2.6179
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) -2.59675
HSPB1 heat shock 27kDa protein 1 -2.5929
GTSE1 G-2 and S-phase expressed 1 -2.59279
ERCC6L excision repair cross-complementation group 6-like -2.59055
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit -2.585
SLC35B1 solute carrier family 35, member B1 -2.5598
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.55495
COPS4 COP9 signalosome subunit 4 -2.55295
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 -2.5525
RFC2 replication factor C (activator 1) 2, 40kDa -2.55228
LMNB1 lamin B1 -2.5507
GINS2 GINS complex subunit 2 (Psf2 homolog) -2.5476
XPO1 exportin 1 -2.5421
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa -2.53842
GIN1 gypsy retrotransposon integrase 1 -2.537
RAD51AP1 RAD51 associated protein 1 -2.53635
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.5336
TDP1 tyrosyl-DNA phosphodiesterase 1 -2.53185
RHOT1 ras homolog family member T1 -2.5272
FANCI Fanconi anemia, complementation group I -2.52252
RAD21 RAD21 homolog (S. pombe) -2.5211
ZNF184 zinc finger protein 184 -2.5193
MFAP4 microfibrillar-associated protein 4 -2.514
ETFB electron-transfer-flavoprotein, beta polypeptide -2.49575
PHGDH phosphoglycerate dehydrogenase -2.4951
NPM3 nucleophosmin/nucleoplasmin 3 -2.4817
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) -2.4815
S100A4 S100 calcium binding protein A4 -2.48015
DNM1 dynamin 1 -2.47625
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 -2.47415
VBP1 von Hippel-Lindau binding protein 1 -2.47305
MYCBP MYC binding protein -2.47107
MAGEC2 melanoma antigen family C2 -2.47045
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -2.46461
STARD7 StAR-related lipid transfer (START) domain containing 7 -2.4635
TRAK2 trafficking protein, kinesin binding 2 -2.45855
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 -2.45845
SAR1B secretion associated, Ras related GTPase 1B -2.4485
RPL39L ribosomal protein L39-like -2.44265
PGM1 phosphoglucomutase 1 -2.4412
COX5B cytochrome c oxidase subunit Vb -2.43843
IL13RA2 interleukin 13 receptor, alpha 2 -2.4379
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) -2.4379
CKAP5 cytoskeleton associated protein 5 -2.43735
RAB33B RAB33B, member RAS oncogene family -2.43163
ELP5 elongator acetyltransferase complex subunit 5 -2.42925
DCP2 decapping mRNA 2 -2.4184
COMMD3-BMI1 COMMD3-BMI1 readthrough -2.418
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa -2.41795
PMCH pro-melanin-concentrating hormone -2.416
TAC4 tachykinin 4 (hemokinin) -2.4133
ANXA7 annexin A7 -2.41065
SEC61G Sec61 gamma subunit -2.40505
BNIP1 BCL2/adenovirus E1B 19kDa interacting protein 1 -2.40418
CDC6 cell division cycle 6 -2.40162
GGNBP2 gametogenetin binding protein 2 -2.39925
GARRE1 granule associated Rac and RHOG effector 1 -2.3938
ZNF106 zinc finger protein 106 -2.3935
SNRPC small nuclear ribonucleoprotein polypeptide C -2.39265
HSPA14 heat shock 70kDa protein 14 -2.38825
POLG2 polymerase (DNA directed), gamma 2, accessory subunit -2.38657
NDC1 NDC1 transmembrane nucleoporin -2.37995
NCAPG2 non-SMC condensin II complex, subunit G2 -2.3794
YME1L1 YME1-like 1 ATPase -2.37742
CENPS-CORT CENPS-CORT readthrough -2.37195
LOC128966597 MAL-like protein -2.3683
TMPO thymopoietin -2.36045
SNRPG small nuclear ribonucleoprotein polypeptide G -2.35775
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 -2.35215
GGCT gamma-glutamylcyclotransferase -2.35155
MRPL12 mitochondrial ribosomal protein L12 -2.3403
DDB1 damage-specific DNA binding protein 1, 127kDa -2.3402
TFAM transcription factor A, mitochondrial -2.33768
SUB1 SUB1 homolog (S. cerevisiae) -2.33707
TIMM23 translocase of inner mitochondrial membrane 23 homolog (yeast) -2.3368
AP1S2 adaptor-related protein complex 1, sigma 2 subunit -2.33623
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 -2.33565
STIL SCL/TAL1 interrupting locus -2.3342
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -2.33145
EAPP E2F-associated phosphoprotein -2.324
BOLA1 bolA family member 1 -2.3233
GOLT1A golgi transport 1A -2.32185
HMGN1 high mobility group nucleosome binding domain 1 -2.32165
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 -2.3146
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -2.3121
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa -2.30735
HSDL2 hydroxysteroid dehydrogenase like 2 -2.30597
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast) -2.3021
NUP43 nucleoporin 43kDa -2.29995
PCCB propionyl CoA carboxylase, beta polypeptide -2.29075
PTBP3 polypyrimidine tract binding protein 3 -2.28917
ENG endoglin -2.28785
BARD1 BRCA1 associated RING domain 1 -2.28575
ATP5F1C ATP synthase F1 subunit gamma -2.27765
HIGD1A HIG1 hypoxia inducible domain family, member 1A -2.27682
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -2.26785
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -2.2667
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) -2.26405
BTBD1 BTB (POZ) domain containing 1 -2.26035
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma -2.26015
SSR1 signal sequence receptor, alpha -2.25284
ANXA2 annexin A2 -2.25022
YEATS4 YEATS domain containing 4 -2.25015
RCC1 regulator of chromosome condensation 1 -2.24853
PGAM4 phosphoglycerate mutase family member 4 -2.24115
ZBTB32 zinc finger and BTB domain containing 32 -2.2333
PRR15L proline rich 15-like -2.22845
PTPN20 protein tyrosine phosphatase, non-receptor type 20 -2.2202
ZDHHC6 zinc finger, DHHC-type containing 6 -2.2179
ZWINT ZW10 interacting kinetochore protein -2.2165
PDCD10 programmed cell death 10 -2.2158
CPVL carboxypeptidase, vitellogenic-like -2.21375
GOLGA7 golgin A7 -2.2093
COL3A1 collagen, type III, alpha 1 -2.19635
FEN1 flap structure-specific endonuclease 1 -2.19453
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae) -2.19385
GNG12 guanine nucleotide binding protein (G protein), gamma 12 -2.1938
CARD8 caspase recruitment domain family, member 8 -2.19025
INPP1 inositol polyphosphate-1-phosphatase -2.18885
ASDURF ASNSD1 upstream open reading frame -2.1887
PEX3 peroxisomal biogenesis factor 3 -2.18012
EXO1 exonuclease 1 -2.17785
FKBP3 FK506 binding protein 3, 25kDa -2.1777
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.17767
C1QBP complement component 1, q subcomponent binding protein -2.17757
ZNF226 zinc finger protein 226 -2.17285
BCLAF1 BCL2-associated transcription factor 1 -2.17026
CDC123 cell division cycle 123 -2.1636
TBC1D15 TBC1 domain family, member 15 -2.1606
EXOSC8 exosome component 8 -2.1581
ITK IL2-inducible T-cell kinase -2.1531
MRPS7 mitochondrial ribosomal protein S7 -2.1526
CDK5RAP1 CDK5 regulatory subunit associated protein 1 -2.15235
ACYP1 acylphosphatase 1, erythrocyte (common) type -2.15115
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 -2.14975
RWDD1 RWD domain containing 1 -2.14455
PSPH phosphoserine phosphatase -2.14447
NANS N-acetylneuraminic acid synthase -2.14445
LACTB2 lactamase, beta 2 -2.1435
CHKA choline kinase alpha -2.1427
TP53RK TP53 regulating kinase -2.13925
CUTC cutC copper transporter -2.1379
MGP matrix Gla protein -2.1359
IDI1 isopentenyl-diphosphate delta isomerase 1 -2.13457
MDH1 malate dehydrogenase 1, NAD (soluble) -2.134
IDE insulin-degrading enzyme -2.13282
ARHGAP19 Rho GTPase activating protein 19 -2.13252
GALK1 galactokinase 1 -2.1308
MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria -2.1291
KIN Kin17 DNA and RNA binding protein -2.1291
PPA2 pyrophosphatase (inorganic) 2 -2.1224
S100A2 S100 calcium binding protein A2 -2.119
DPAGT1 dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase) -2.11597
RNF167 ring finger protein 167 -2.11425
ENY2 enhancer of yellow 2 homolog (Drosophila) -2.11425
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5 -2.1104
TFB1M transcription factor B1, mitochondrial -2.10885
ECHDC1 ethylmalonyl-CoA decarboxylase 1 -2.1084
CHEK1 checkpoint kinase 1 -2.10625
FASTKD3 FAST kinase domains 3 -2.1018
MLEC malectin -2.09787
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -2.0953
OXCT1 3-oxoacid CoA transferase 1 -2.09405
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa -2.0895
NOX5 NADPH oxidase, EF-hand calcium binding domain 5 -2.08835
GSTA4 glutathione S-transferase alpha 4 -2.0882
TRIAP1 TP53 regulated inhibitor of apoptosis 1 -2.0875
ACP6 acid phosphatase 6, lysophosphatidic -2.087
ZFAND1 zinc finger, AN1-type domain 1 -2.08655
DSN1 DSN1, MIS12 kinetochore complex component -2.08645
HAUS4 HAUS augmin-like complex, subunit 4 -2.0853
ZFC3H1 zinc finger, C3H1-type containing -2.08495
PTGES3 prostaglandin E synthase 3 (cytosolic) -2.0814
NUP133 nucleoporin 133kDa -2.08085
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -2.08025
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -2.0765
TEX30 testis expressed 30 -2.0764
BRIX1 BRX1, biogenesis of ribosomes -2.0752
IRX5 iroquois homeobox 5 -2.07375
H2AZ1 H2A.Z variant histone 1 -2.0668
DCPS decapping enzyme, scavenger -2.06525
SLC35F2 solute carrier family 35, member F2 -2.06465
MTCH2 mitochondrial carrier 2 -2.0641
FIRRM FIGNL1 interacting regulator of recombination and mitosis -2.06385
PGC progastricsin (pepsinogen C) -2.06285
ZNF211 zinc finger protein 211 -2.0623
HAX1 HCLS1 associated protein X-1 -2.06185
FAM32A family with sequence similarity 32, member A -2.0609
STARD13 StAR-related lipid transfer (START) domain containing 13 -2.05055
TUBA1B tubulin, alpha 1b -2.0504
HOPX HOP homeobox -2.0499
RFC5 replication factor C (activator 1) 5, 36.5kDa -2.03998
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1 -2.03985
ERAL1 Era-like 12S mitochondrial rRNA chaperone 1 -2.03645
RIPPLY2-CYB5R4 RIPPLY2-CYB5R4 readthrough -2.03535
BMS1 BMS1 ribosome biogenesis factor -2.0352
NPY1R neuropeptide Y receptor Y1 -2.0325
CATSPERZ catsper channel auxiliary subunit zeta -2.0324
DHCR7 7-dehydrocholesterol reductase -2.03137
SRP9 signal recognition particle 9kDa -2.03125
DHFR dihydrofolate reductase -2.03121
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae) -2.03085
HLA-DRB3 major histocompatibility complex, class II, DR beta 3 -2.03055
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1 -2.029
PCDHB16 protocadherin beta 16 -2.02615
TMED9 transmembrane emp24 protein transport domain containing 9 -2.02565
PXMP4 peroxisomal membrane protein 4, 24kDa -2.0184
ANKRD49 ankyrin repeat domain 49 -2.0168
ECI2 enoyl-CoA delta isomerase 2 -2.0156
MIS12 MIS12 kinetochore complex component -2.0152
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 -2.015
POLK polymerase (DNA directed) kappa -2.01355
CCT4 chaperonin containing TCP1, subunit 4 (delta) -2.01115
LGALS7B lectin, galactoside-binding, soluble, 7B -2.01095
RAB5IF RAB5 interacting factor -2.01015
THEM6 thioesterase superfamily member 6 -2.008
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.00675
MARCHF7 membrane associated ring-CH-type finger 7 -2.00542