CRCGN017_MCF10A.TP53.M_24H:K12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description wortmannin 1.11 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

66 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:K12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.02046
KLHL21 kelch-like family member 21 3.61273
AGR2 anterior gradient 2 3.6122
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.4728
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 3.29978
MSRA methionine sulfoxide reductase A 3.175
SCCPDH saccharopine dehydrogenase (putative) 2.83818
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.66101
NPDC1 neural proliferation, differentiation and control, 1 2.55345
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 2.38153
DPYD dihydropyrimidine dehydrogenase 2.3735
MICALL2 MICAL-like 2 2.26278
AHNAK2 AHNAK nucleoprotein 2 2.23871
CXCL2 chemokine (C-X-C motif) ligand 2 2.2031
HSPA1A heat shock 70kDa protein 1A 2.18988
DKK1 dickkopf WNT signaling pathway inhibitor 1 2.18553
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 2.15631
KIF11 kinesin family member 11 2.1313
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.10047
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 2.09713
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.08371
ADRB2 adrenoceptor beta 2, surface 2.06331
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1 2.04358
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 2.03063
GGT5 gamma-glutamyltransferase 5 2.00547

decreased expression

Symbol Name Standardized Value
TNIP1 TNFAIP3 interacting protein 1 -5.57495
TXNDC9 thioredoxin domain containing 9 -4.23847
UFM1 ubiquitin-fold modifier 1 -3.99913
LYPLA1 lysophospholipase I -3.27378
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.14325
HAT1 histone acetyltransferase 1 -3.09569
RNF167 ring finger protein 167 -2.81916
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -2.8029
CAB39 calcium binding protein 39 -2.69271
RXYLT1 ribitol xylosyltransferase 1 -2.68952
TRIB3 tribbles pseudokinase 3 -2.5641
SNCA synuclein, alpha (non A4 component of amyloid precursor) -2.54233
THAP11 THAP domain containing 11 -2.54061
CDK7 cyclin-dependent kinase 7 -2.53062
SNX3 sorting nexin 3 -2.52776
LIPT1 lipoyltransferase 1 -2.3799
MED7 mediator complex subunit 7 -2.36015
PPARG peroxisome proliferator-activated receptor gamma -2.35696
HAX1 HCLS1 associated protein X-1 -2.35591
CDK20 cyclin-dependent kinase 20 -2.35157
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -2.31952
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator -2.21719
GOLT1B golgi transport 1B -2.21252
HSPA13 heat shock protein 70kDa family, member 13 -2.20843
ODR4 odr-4 GPCR localization factor homolog -2.20253
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -2.20194
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2 -2.19177
UNC50 unc-50 homolog (C. elegans) -2.18982
INTS12 integrator complex subunit 12 -2.18474
INPP1 inositol polyphosphate-1-phosphatase -2.17731
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 -2.16664
SLC35F2 solute carrier family 35, member F2 -2.1618
KCTD11 potassium channel tetramerization domain containing 11 -2.11338
MAP2K1 mitogen-activated protein kinase kinase 1 -2.08941
SSR2 signal sequence receptor, beta (translocon-associated protein beta) -2.08895
TUBA4A tubulin, alpha 4a -2.08205
VAMP7 vesicle-associated membrane protein 7 -2.06859
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 -2.06597
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -2.0536
AQP5 aquaporin 5 -2.05151
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -2.02803