CRCGN017_MCF10A.TP53.M_24H:K17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-aminoanthracene 33.77 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

56 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:K17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LAGE3 L antigen family, member 3 4.6837
SNAP25 synaptosomal-associated protein, 25kDa 3.59935
SPAG4 sperm associated antigen 4 3.27225
ACAA1 acetyl-CoA acyltransferase 1 3.16576
E2F2 E2F transcription factor 2 3.13407
MICALL1 MICAL-like 1 2.93411
CCP110 centriolar coiled coil protein 110kDa 2.89965
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 2.48207
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.40101
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 2.22307
MRPL18 mitochondrial ribosomal protein L18 2.17459
CAMKMT calmodulin-lysine N-methyltransferase 2.15309
OCEL1 occludin/ELL domain containing 1 2.13288
RBKS ribokinase 2.11638
HOXA5 homeobox A5 2.11119
ODAM odontogenic, ameloblast asssociated 2.09468
PABPC3 poly(A) binding protein, cytoplasmic 3 2.01996
UFC1 ubiquitin-fold modifier conjugating enzyme 1 2.01817

decreased expression

Symbol Name Standardized Value
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -4.88442
RPIA ribose 5-phosphate isomerase A -4.00162
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -3.49555
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -3.44866
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.21575
WASHC4 WASH complex subunit 4 -3.16542
GTPBP8 GTP-binding protein 8 (putative) -3.04524
MRPS2 mitochondrial ribosomal protein S2 -2.97803
LDHD lactate dehydrogenase D -2.8874
NAMPT nicotinamide phosphoribosyltransferase -2.69135
ECHDC3 enoyl CoA hydratase domain containing 3 -2.66697
TRIB3 tribbles pseudokinase 3 -2.4584
TRAPPC14 trafficking protein particle complex subunit 14 -2.41855
FOS FBJ murine osteosarcoma viral oncogene homolog -2.37189
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -2.35319
PPP1R26 protein phosphatase 1, regulatory subunit 26 -2.33719
ADRB2 adrenoceptor beta 2, surface -2.31779
GNG11 guanine nucleotide binding protein (G protein), gamma 11 -2.29148
PUS7 pseudouridylate synthase 7 (putative) -2.27531
AGK acylglycerol kinase -2.24156
HEATR1 HEAT repeat containing 1 -2.20254
NECAP2 NECAP endocytosis associated 2 -2.19831
COG5 component of oligomeric golgi complex 5 -2.18855
ECM2 extracellular matrix protein 2, female organ and adipocyte specific -2.1877
MED22 mediator complex subunit 22 -2.18151
CREB1 cAMP responsive element binding protein 1 -2.1796
CYB561 cytochrome b561 -2.14653
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast) -2.14359
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase -2.12894
BCAP29 B-cell receptor-associated protein 29 -2.12661
DUS4L dihydrouridine synthase 4-like (S. cerevisiae) -2.12587
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta -2.11059
ZFPM2 zinc finger protein, FOG family member 2 -2.10952
LYRM4 LYR motif containing 4 -2.07466
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2 -2.0671
RASA2 RAS p21 protein activator 2 -2.06521
CMTR1 cap methyltransferase 1 -2.04894
ARHGAP29 Rho GTPase activating protein 29 -2.00752