CRCGN017_MCF10A.TP53.M_24H:K19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sodium 4-((e)-{5-methoxy-4-[(e)-(4-methoxyphenyl)diazenyl]-2-methylphenyl}diazenyl)benzenesulfonate 99.61 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

23 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:K19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GPER1 G protein-coupled estrogen receptor 1 4.44525
CNRIP1 cannabinoid receptor interacting protein 1 4.39982
HDGFL3 HDGF like 3 4.0333
VAV3 vav 3 guanine nucleotide exchange factor 3.52903
BEX3 brain expressed X-linked 3 2.67224
KDM5D lysine (K)-specific demethylase 5D 2.60225
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.55234
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 2.53577
NFIL3 nuclear factor, interleukin 3 regulated 2.24893
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.10668
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 2.06185

decreased expression

Symbol Name Standardized Value
HACD3 3-hydroxyacyl-CoA dehydratase 3 -4.25932
HAT1 histone acetyltransferase 1 -3.43658
NGRN neugrin, neurite outgrowth associated -3.19661
RGS2 regulator of G-protein signaling 2 -3.01064
SMNDC1 survival motor neuron domain containing 1 -2.68813
IFRD2 interferon-related developmental regulator 2 -2.49122
TMEM115 transmembrane protein 115 -2.46522
LOC124905557 eukaryotic translation initiation factor 1A, X-chromosomal -2.35361
SMC1A structural maintenance of chromosomes 1A -2.23031
KDM5C lysine (K)-specific demethylase 5C -2.1493
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 -2.01328
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -2.00929