CRCGN017_MCF10A.TP53.M_24H:K21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sodium 4-((e)-{5-methoxy-4-[(e)-(4-methoxyphenyl)diazenyl]-2-methylphenyl}diazenyl)benzenesulfonate 11.07 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

90 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:K21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HBA1 hemoglobin, alpha 1 6.8963
LAGE3 L antigen family, member 3 6.00595
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 5.45433
STAP2 signal transducing adaptor family member 2 5.2627
SSBP2 single-stranded DNA binding protein 2 5.14207
ADO 2-aminoethanethiol (cysteamine) dioxygenase 5.10895
C2CD2 C2 calcium-dependent domain containing 2 4.8944
HBB hemoglobin, beta 4.76602
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 4.42028
TBX2 T-box 2 3.5095
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.28343
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.99325
DCTPP1 dCTP pyrophosphatase 1 2.7184
TBXA2R thromboxane A2 receptor 2.58891
CCDC6 coiled-coil domain containing 6 2.47585
GPATCH8 G patch domain containing 8 2.42307
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like 2.4152
NRBF2 nuclear receptor binding factor 2 2.3775
FIBP fibroblast growth factor (acidic) intracellular binding protein 2.35085
FAM3A family with sequence similarity 3, member A 2.25793
AGR2 anterior gradient 2 2.24945
HOXB2 homeobox B2 2.2316
PCNP PEST proteolytic signal containing nuclear protein 2.2218
SMAD7 SMAD family member 7 2.21945
BBS10 Bardet-Biedl syndrome 10 2.20865
FAM168A family with sequence similarity 168, member A 2.196
ZFP30 ZFP30 zinc finger protein 2.1912
TRAPPC4 trafficking protein particle complex 4 2.15217
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 2.14575
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 2.1387
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 2.13455
PPCS phosphopantothenoylcysteine synthetase 2.1236
JRKL JRK-like 2.11785
EXD2 exonuclease 3'-5' domain containing 2 2.0968
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 2.0913
GLRX5 glutaredoxin 5 2.08845
GTF2H2C GTF2H2 family member C 2.08842
FTO fat mass and obesity associated 2.0637
POLR2M polymerase (RNA) II (DNA directed) polypeptide M 2.0608
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.05775
NKIRAS2 NFKB inhibitor interacting Ras-like 2 2.05538
CH25H cholesterol 25-hydroxylase 2.052
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase 2.0505
KAT7 K(lysine) acetyltransferase 7 2.04985
CCDC85B coiled-coil domain containing 85B 2.0362
SYNM synemin, intermediate filament protein 2.0268
PARG poly (ADP-ribose) glycohydrolase 2.0203
MRPS27 mitochondrial ribosomal protein S27 2.0093
GCA grancalcin, EF-hand calcium binding protein 2.00335
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant 2.00115

decreased expression

Symbol Name Standardized Value
CD58 CD58 molecule -8.38558
YME1L1 YME1-like 1 ATPase -5.46102
TSPAN4 tetraspanin 4 -5.06305
CDC45 cell division cycle 45 -4.94805
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -4.53415
SCYL3 SCY1-like 3 (S. cerevisiae) -4.12582
TLK2 tousled-like kinase 2 -3.7169
IGSF3 immunoglobulin superfamily, member 3 -2.8234
ABI1 abl-interactor 1 -2.64562
MTPAP mitochondrial poly(A) polymerase -2.57535
CAB39 calcium binding protein 39 -2.54265
KIFAP3 kinesin-associated protein 3 -2.5088
ANKRD10 ankyrin repeat domain 10 -2.4828
PRPF18 pre-mRNA processing factor 18 -2.4656
FOXE1 forkhead box E1 -2.46
RBM15B RNA binding motif protein 15B -2.41725
WAC WW domain containing adaptor with coiled-coil -2.39722
LOC127933115 uncharacterized LOC127933115 -2.3961
FAIM Fas apoptotic inhibitory molecule -2.39405
SFT2D2 SFT2 domain containing 2 -2.3774
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin -2.37445
RAB38 RAB38, member RAS oncogene family -2.31895
KDM3A lysine (K)-specific demethylase 3A -2.30825
CD163 CD163 molecule -2.25245
SOX5 SRY (sex determining region Y)-box 5 -2.23975
TPO thyroid peroxidase -2.2283
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 -2.22503
CGREF1 cell growth regulator with EF-hand domain 1 -2.16135
CACNG1 calcium channel, voltage-dependent, gamma subunit 1 -2.1481
PDGFRL platelet-derived growth factor receptor-like -2.1471
CDK5RAP2 CDK5 regulatory subunit associated protein 2 -2.10935
VSIG4 V-set and immunoglobulin domain containing 4 -2.10685
LOC105379278 uncharacterized LOC105379278 -2.10525
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) -2.0951
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 -2.08208
TRIP12 thyroid hormone receptor interactor 12 -2.0421
RTL10 retrotransposon Gag like 10 -2.0399
HDHD5 haloacid dehalogenase like hydrolase domain containing 5 -2.0337
EMC3 ER membrane protein complex subunit 3 -2.01635
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 -2.0149