CRCGN017_MCF10A.TP53.M_24H:L01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description o-nitrotoluene 100.8 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

226 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:L01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
KLHL21 kelch-like family member 21 6.3474
LAGE3 L antigen family, member 3 5.579
CNRIP1 cannabinoid receptor interacting protein 1 5.2934
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 4.86375
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.48115
WIF1 WNT inhibitory factor 1 4.0037
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 3.95925
KLHL9 kelch-like family member 9 3.47025
IGHMBP2 immunoglobulin mu binding protein 2 3.36847
TOR1AIP2 torsin A interacting protein 2 3.31135
FAM50A family with sequence similarity 50, member A 3.304
TMEM134 transmembrane protein 134 3.1811
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma 3.05365
CAPNS1 calpain, small subunit 1 2.90945
ATP5IF1 ATP synthase inhibitory factor subunit 1 2.89725
LGSN lengsin, lens protein with glutamine synthetase domain 2.8298
DCTN3 dynactin 3 (p22) 2.77395
F8A2 coagulation factor VIII-associated 2 2.74635
SRSF9 serine/arginine-rich splicing factor 9 2.72785
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11 2.72175
MELK maternal embryonic leucine zipper kinase 2.58195
SNRNP35 small nuclear ribonucleoprotein 35kDa (U11/U12) 2.5636
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 2.5249
ACAA1 acetyl-CoA acyltransferase 1 2.51955
CKAP2 cytoskeleton associated protein 2 2.51115
ERCC5 excision repair cross-complementation group 5 2.5008
S100PBP S100P binding protein 2.5003
WASHC3 WASH complex subunit 3 2.4939
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 2.46955
RNF34 ring finger protein 34, E3 ubiquitin protein ligase 2.4691
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit 2.46765
HMGN3 high mobility group nucleosomal binding domain 3 2.46335
AACS acetoacetyl-CoA synthetase 2.42435
SF3B5 splicing factor 3b, subunit 5, 10kDa 2.41965
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit 2.40475
FOCAD focadhesin 2.40445
TENT5A terminal nucleotidyltransferase 5A 2.39105
RPL39 ribosomal protein L39 2.378
AGR2 anterior gradient 2 2.3698
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2 2.3579
COXFA4 cytochrome c oxidase associated subunit FA4 2.35035
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 2.35005
ARL5A ADP-ribosylation factor-like 5A 2.2985
DYNLRB1 dynein, light chain, roadblock-type 1 2.2905
WSB2 WD repeat and SOCS box containing 2 2.26485
DENR density-regulated protein 2.2617
QPRT quinolinate phosphoribosyltransferase 2.2599
RINT1 RAD50 interactor 1 2.25855
SSH3 slingshot protein phosphatase 3 2.2499
PEBP1 phosphatidylethanolamine binding protein 1 2.24773
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase 2.2421
SLC25A2 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2 2.23915
EOLA1 endothelium and lymphocyte associated ASCH domain 1 2.23755
GLB1 galactosidase, beta 1 2.23515
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa 2.2275
UNC119B unc-119 homolog B (C. elegans) 2.2274
RETREG3 reticulophagy regulator family member 3 2.22375
SPTSSA serine palmitoyltransferase, small subunit A 2.21633
IFT52 intraflagellar transport 52 2.2063
MAN2B2 mannosidase, alpha, class 2B, member 2 2.20295
HAPSTR1 HUWE1 associated protein modifying stress responses 2.2017
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4 2.19247
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.1911
CAPN1 calpain 1, (mu/I) large subunit 2.1792
ATP5ME ATP synthase membrane subunit e 2.17908
KRT10 keratin 10, type I 2.17043
PRKCZ protein kinase C, zeta 2.16865
DPP3 dipeptidyl-peptidase 3 2.15675
ISCU iron-sulfur cluster assembly enzyme 2.1534
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 2.14735
COQ8A coenzyme Q8A 2.1425
RAB5IF RAB5 interacting factor 2.14235
EMD emerin 2.13875
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C 2.1314
AP5M1 adaptor-related protein complex 5, mu 1 subunit 2.119
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) 2.1156
ANXA8L1 annexin A8-like 1 2.10635
ANXA6 annexin A6 2.10455
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) 2.1034
CKS2 CDC28 protein kinase regulatory subunit 2 2.0933
RNF113A ring finger protein 113A 2.07965
FBRS fibrosin 2.07725
EEIG1 estrogen-induced osteoclastogenesis regulator 1 2.0748
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 2.07475
RPS23 ribosomal protein S23 2.065
UBL4A ubiquitin-like 4A 2.05635
DYNLL1 dynein, light chain, LC8-type 1 2.0429
NDUFS5 NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) 2.0377
FKBP9 FK506 binding protein 9, 63 kDa 2.03395
TDG thymine-DNA glycosylase 2.02655
PTMA prothymosin, alpha 2.01803
IRAK1 interleukin-1 receptor-associated kinase 1 2.0176
MLYCD malonyl-CoA decarboxylase 2.01105
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 2.009
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 2.0072

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -4.75525
HACD3 3-hydroxyacyl-CoA dehydratase 3 -4.6559
CTNND1 catenin (cadherin-associated protein), delta 1 -4.17158
CRK v-crk avian sarcoma virus CT10 oncogene homolog -4.14833
CD320 CD320 molecule -3.88535
IFRD2 interferon-related developmental regulator 2 -3.6741
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.4467
C2CD5 C2 calcium-dependent domain containing 5 -3.3866
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 -3.3194
ANTKMT adenine nucleotide translocase lysine methyltransferase -3.0867
RAI14 retinoic acid induced 14 -2.9974
C1QBP complement component 1, q subcomponent binding protein -2.94023
ZNF232 zinc finger protein 232 -2.88015
CCRL2 chemokine (C-C motif) receptor-like 2 -2.8354
KDM3A lysine (K)-specific demethylase 3A -2.8074
TRABD TraB domain containing -2.77995
FZD4 frizzled class receptor 4 -2.7473
GDPD2 glycerophosphodiester phosphodiesterase domain containing 2 -2.68605
APEH acylaminoacyl-peptide hydrolase -2.6685
ANG angiogenin, ribonuclease, RNase A family, 5 -2.64895
CCN2 cellular communication network factor 2 -2.6449
AQP9 aquaporin 9 -2.6432
FHIT fragile histidine triad -2.6258
ANOS1 anosmin 1 -2.59615
BYSL bystin-like -2.54895
TBX2 T-box 2 -2.5445
PRUNE2 prune homolog 2 (Drosophila) -2.5334
RAB3B RAB3B, member RAS oncogene family -2.52457
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide -2.5221
GDF3 growth differentiation factor 3 -2.516
MOCS3 molybdenum cofactor synthesis 3 -2.5136
SDC1 syndecan 1 -2.5101
EDC3 enhancer of mRNA decapping 3 -2.48305
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 -2.47172
PCCB propionyl CoA carboxylase, beta polypeptide -2.47015
MBOAT2 membrane bound O-acyltransferase domain containing 2 -2.46765
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 -2.46602
ZSCAN26 zinc finger and SCAN domain containing 26 -2.4558
MPDU1 mannose-P-dolichol utilization defect 1 -2.45475
DCAF10 DDB1 and CUL4 associated factor 10 -2.419
IL33 interleukin 33 -2.4018
RAB23 RAB23, member RAS oncogene family -2.3793
IFNAR1 interferon (alpha, beta and omega) receptor 1 -2.3751
IFNB1 interferon, beta 1, fibroblast -2.37495
ACSS3 acyl-CoA synthetase short-chain family member 3 -2.36685
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -2.36462
RLN2 relaxin 2 -2.3632
ZNF287 zinc finger protein 287 -2.36025
ZNF276 zinc finger protein 276 -2.3305
APOC2 apolipoprotein C-II -2.32845
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter) -2.32575
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4 -2.3114
RPRD1A regulation of nuclear pre-mRNA domain containing 1A -2.30085
PLA2G2E phospholipase A2, group IIE -2.285
SALL2 spalt-like transcription factor 2 -2.2735
IL10RB interleukin 10 receptor, beta -2.2628
PCDHGA1 protocadherin gamma subfamily A, 1 -2.26015
HLX H2.0-like homeobox -2.25055
NCLN nicalin -2.24105
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) -2.24065
HPX hemopexin -2.23542
COG7 component of oligomeric golgi complex 7 -2.23365
DOCK4 dedicator of cytokinesis 4 -2.23305
TLR4 toll-like receptor 4 -2.2238
LTC4S leukotriene C4 synthase -2.2169
PAX6 paired box 6 -2.2109
PECAM1 platelet/endothelial cell adhesion molecule 1 -2.1873
NRXN1 neurexin 1 -2.18635
MYCT1 myc target 1 -2.18565
RARRES2 retinoic acid receptor responder (tazarotene induced) 2 -2.1856
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 -2.17405
RFPL3 ret finger protein-like 3 -2.1709
SCG2 secretogranin II -2.155
CTSD cathepsin D -2.154
MMRN2 multimerin 2 -2.1521
KANK3 KN motif and ankyrin repeat domains 3 -2.1515
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase -2.1474
CFHR5 complement factor H-related 5 -2.13645
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 -2.12635
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 -2.1255
CLIC5 chloride intracellular channel 5 -2.12502
IL9 interleukin 9 -2.1249
FLOT1 flotillin 1 -2.12437
PRRX1 paired related homeobox 1 -2.1208
DOK5 docking protein 5 -2.1172
TLN2 talin 2 -2.11675
MAN2C1 mannosidase, alpha, class 2C, member 1 -2.11455
ARL4C ADP-ribosylation factor-like 4C -2.1125
KATNBL1 katanin p80 subunit B-like 1 -2.10555
NME6 NME/NM23 nucleoside diphosphate kinase 6 -2.1003
GPR176 G protein-coupled receptor 176 -2.0993
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) -2.09503
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -2.09078
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein -2.08365
ATP11B ATPase, class VI, type 11B -2.07875
ZNF253 zinc finger protein 253 -2.0769
GAS1 growth arrest-specific 1 -2.07577
PPEF1 protein phosphatase, EF-hand calcium binding domain 1 -2.0755
PTPRK protein tyrosine phosphatase, receptor type, K -2.0739
VARS1 valyl-tRNA synthetase 1 -2.07345
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide -2.0721
AMOT angiomotin -2.0629
CTCF CCCTC-binding factor (zinc finger protein) -2.05535
ZNF91 zinc finger protein 91 -2.05085
NCF4 neutrophil cytosolic factor 4, 40kDa -2.05043
CD300A CD300a molecule -2.0491
CD93 CD93 molecule -2.04725
TTLL12 tubulin tyrosine ligase-like family member 12 -2.04655
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) -2.0446
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.0423
FKBP4 FK506 binding protein 4, 59kDa -2.04142
RMDN3 regulator of microtubule dynamics 3 -2.03895
LYPLA1-TCEA1 LYPLA1-TCEA1 readthrough -2.0381
RABEP1 rabaptin, RAB GTPase binding effector protein 1 -2.0376
POLRMT polymerase (RNA) mitochondrial (DNA directed) -2.036
CXCR1 chemokine (C-X-C motif) receptor 1 -2.03425
IRF1 interferon regulatory factor 1 -2.0341
PCDH8 protocadherin 8 -2.0334
MMD monocyte to macrophage differentiation-associated -2.02395
EXO5 exonuclease 5 -2.0225
C5AR1 complement component 5a receptor 1 -2.0198
ACVRL1 activin A receptor type II-like 1 -2.01865
BMX BMX non-receptor tyrosine kinase -2.01815
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase -2.01807
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa -2.0157
GUCY1A2 guanylate cyclase 1, soluble, alpha 2 -2.01225
IL15RA interleukin 15 receptor, alpha -2.01045
AMBP alpha-1-microglobulin/bikunin precursor -2.00435
RGS11 regulator of G-protein signaling 11 -2.00117
VNN2 vanin 2 -2.0001
RNF123 ring finger protein 123 -2.0001