CRCGN017_MCF10A.TP53.M_24H:L09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description acrylonitrile 12.7 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

33 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:L09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABHD6 abhydrolase domain containing 6 3.87455
HYOU1 hypoxia up-regulated 1 3.48135
WFS1 Wolfram syndrome 1 (wolframin) 3.16419
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.12865
GATA3 GATA binding protein 3 2.64624
IGHMBP2 immunoglobulin mu binding protein 2 2.3579
HBA1 hemoglobin, alpha 1 2.34494
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.28367
SPDEF SAM pointed domain containing ETS transcription factor 2.18561
CHEK1 checkpoint kinase 1 2.17415
ZNF587 zinc finger protein 587 2.16889

decreased expression

Symbol Name Standardized Value
RNF167 ring finger protein 167 -3.83954
DNM1L dynamin 1-like -3.39
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.29127
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -3.29061
C2CD5 C2 calcium-dependent domain containing 5 -3.07026
FOS FBJ murine osteosarcoma viral oncogene homolog -3.04545
MSMO1 methylsterol monooxygenase 1 -3.04295
CAB39 calcium binding protein 39 -2.79217
MED21 mediator complex subunit 21 -2.79092
CREB1 cAMP responsive element binding protein 1 -2.69554
KRT14 keratin 14, type I -2.68876
BASP1 brain abundant, membrane attached signal protein 1 -2.63595
BID BH3 interacting domain death agonist -2.47032
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -2.45842
CAPRIN2 caprin family member 2 -2.41725
CCNA1 cyclin A1 -2.37533
TUBA4A tubulin, alpha 4a -2.3476
TRAPPC3 trafficking protein particle complex 3 -2.34229
EFHD2 EF-hand domain family, member D2 -2.22781
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.098
DUSP5 dual specificity phosphatase 5 -2.06426
CDH15 cadherin 15, type 1, M-cadherin (myotubule) -2.03338