CRCGN017_MCF10A.TP53.M_24H:L13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-nitropropane 98.8 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

96 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:L13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 5.2869
KLHL21 kelch-like family member 21 4.93405
HBA1 hemoglobin, alpha 1 4.61998
ZNF134 zinc finger protein 134 4.4964
ZNF586 zinc finger protein 586 4.1159
TOMM34 translocase of outer mitochondrial membrane 34 3.89225
ZNF211 zinc finger protein 211 3.62215
ZNF551 zinc finger protein 551 3.5261
ZNF419 zinc finger protein 419 3.33278
ZNF304 zinc finger protein 304 3.30345
ZNF587 zinc finger protein 587 3.1522
ZNF761 zinc finger protein 761 2.8437
GRB10 growth factor receptor-bound protein 10 2.78322
ZNF587B zinc finger protein 587B 2.57095
MINDY1 MINDY lysine 48 deubiquitinase 1 2.5069
EVL Enah/Vasp-like 2.3083
BLMH bleomycin hydrolase 2.24915
PNRC2 proline-rich nuclear receptor coactivator 2 2.2155
CTSZ cathepsin Z 2.191
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 2.17355
ZNF84 zinc finger protein 84 2.1657
UBXN8 UBX domain protein 8 2.1615
ZNF443 zinc finger protein 443 2.1481
TRIM28 tripartite motif containing 28 2.12005
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.09215
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C 2.08395
MSL2 male-specific lethal 2 homolog (Drosophila) 2.0835
SAE1 SUMO1 activating enzyme subunit 1 2.07575
GNG12 guanine nucleotide binding protein (G protein), gamma 12 2.0695
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 2.05165
CHMP2A charged multivesicular body protein 2A 2.03035
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 2.0296
UBE2M ubiquitin-conjugating enzyme E2M 2.0188
BMAL2 basic helix-loop-helix ARNT like 2 2.0077
PITX1 paired-like homeodomain 1 2.00058

decreased expression

Symbol Name Standardized Value
HMG20B high mobility group 20B -5.36783
COG2 component of oligomeric golgi complex 2 -5.0447
COG7 component of oligomeric golgi complex 7 -5.0
GDF15 growth differentiation factor 15 -4.8165
TCTA T-cell leukemia translocation altered -4.4035
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide -4.24773
BASP1 brain abundant, membrane attached signal protein 1 -3.8643
TRAPPC3 trafficking protein particle complex 3 -3.6782
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -3.38715
MRPS15 mitochondrial ribosomal protein S15 -3.2775
PRUNE2 prune homolog 2 (Drosophila) -3.00607
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 -2.80215
IER5 immediate early response 5 -2.77965
UBFD1 ubiquitin family domain containing 1 -2.5807
SEC24B SEC24 family member B -2.5204
MTMR14 myotubularin related protein 14 -2.4451
KATNIP katanin interacting protein -2.4448
MRNIP MRN complex interacting protein -2.3797
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase -2.3587
NGRN neugrin, neurite outgrowth associated -2.3457
SUGCT succinyl-CoA:glutarate-CoA transferase -2.3439
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma -2.32995
BPHL biphenyl hydrolase-like (serine hydrolase) -2.311
CIB1 calcium and integrin binding 1 (calmyrin) -2.2926
CNN1 calponin 1, basic, smooth muscle -2.28995
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 -2.2756
TENT4A terminal nucleotidyltransferase 4A -2.25805
AGO1 argonaute RISC catalytic component 1 -2.23835
HIRIP3 HIRA interacting protein 3 -2.21625
IL10RB interleukin 10 receptor, beta -2.2139
CBY1 chibby homolog 1 (Drosophila) -2.21035
NAGA N-acetylgalactosaminidase, alpha- -2.20293
ABHD11 abhydrolase domain containing 11 -2.2023
NPIPA6 nuclear pore complex interacting protein family, member A6 -2.1919
BLOC1S1 biogenesis of lysosomal organelles complex-1, subunit 1 -2.18885
PPP4C protein phosphatase 4, catalytic subunit -2.18825
HEATR6 HEAT repeat containing 6 -2.1788
LOC124900388 uncharacterized LOC124900388 -2.1696
PRCC papillary renal cell carcinoma (translocation-associated) -2.16745
DRC3 dynein regulatory complex subunit 3 -2.1644
METTL22 methyltransferase like 22 -2.1583
MLF2 myeloid leukemia factor 2 -2.1487
RABGGTA Rab geranylgeranyltransferase, alpha subunit -2.1407
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6 -2.13195
UFD1 ubiquitin recognition factor in ER associated degradation 1 -2.1214
GAK cyclin G associated kinase -2.11985
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae) -2.1082
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial -2.1076
APOC1 apolipoprotein C-I -2.10047
CROT carnitine O-octanoyltransferase -2.0964
FLCN folliculin -2.0936
TULP3 tubby like protein 3 -2.07685
PPP2R2D protein phosphatase 2, regulatory subunit B, delta -2.0763
TIPRL TOR signaling pathway regulator -2.06065
METTL25B methyltransferase like 25B -2.0547
ATG4B autophagy related 4B, cysteine peptidase -2.0444
RNF125 ring finger protein 125, E3 ubiquitin protein ligase -2.04265
MTX1 metaxin 1 -2.0128
MSMB microseminoprotein, beta- -2.00618
COX7A2L cytochrome c oxidase subunit VIIa polypeptide 2 like -2.0017
ACOT13 acyl-CoA thioesterase 13 -2.00035