CRCGN017_MCF10A.TP53.M_24H:L18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description ethyl methanesulfonate 11.26 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

56 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:L18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AMDHD2 amidohydrolase domain containing 2 5.2293
OXSR1 oxidative stress responsive 1 5.1858
SPAG4 sperm associated antigen 4 4.817
MOK MOK protein kinase 4.75115
CXCL2 chemokine (C-X-C motif) ligand 2 4.1766
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.04035
ACAA1 acetyl-CoA acyltransferase 1 3.58008
IGHMBP2 immunoglobulin mu binding protein 2 3.54055
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 3.06995
TBX2 T-box 2 2.89932
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like 2.71465
DENND2D DENN/MADD domain containing 2D 2.66625
MORN1 MORN repeat containing 1 2.5649
KCNQ4 potassium channel, voltage gated KQT-like subfamily Q, member 4 2.43425
MATN4 matrilin 4 2.4324
GRM4 glutamate receptor, metabotropic 4 2.42555
CLDN9 claudin 9 2.3815
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1 2.3471
PNMA3 paraneoplastic Ma antigen 3 2.32295
SSTR5 somatostatin receptor 5 2.31955
MYH13 myosin, heavy chain 13, skeletal muscle 2.3135
RSPH6A radial spoke head 6 homolog A (Chlamydomonas) 2.29225
CATSPERH catsper channel auxiliary subunit eta 2.27295
PDCD1 programmed cell death 1 2.26675
SPTBN2 spectrin, beta, non-erythrocytic 2 2.25405
TRPV4 transient receptor potential cation channel, subfamily V, member 4 2.2057
CLSTN3 calsyntenin 3 2.18935
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific 2.16455
LCN1 lipocalin 1 2.15985
PLEKHJ1 pleckstrin homology domain containing, family J member 1 2.14455
DUX4 double homeobox 4 2.1439
ADGRB1 adhesion G protein-coupled receptor B1 2.1265
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 2.1248
SCT secretin 2.1204
POMT2 protein-O-mannosyltransferase 2 2.10785
CDCA3 cell division cycle associated 3 2.08185
EMC10 ER membrane protein complex subunit 10 2.0558
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11 2.0491
HAND2 heart and neural crest derivatives expressed 2 2.01685
CGB8 chorionic gonadotropin, beta polypeptide 8 2.0156
TLE6 transducin-like enhancer of split 6 2.01545
PSPN persephin 2.01405
KRT3 keratin 3, type II 2.0115
ZNF205 zinc finger protein 205 2.0102
GNRH2 gonadotropin-releasing hormone 2 2.00225

decreased expression

Symbol Name Standardized Value
PUF60 poly-U binding splicing factor 60KDa -4.84
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -4.21982
DYNLT3 dynein, light chain, Tctex-type 3 -3.64195
COTL1 coactosin-like F-actin binding protein 1 -3.50065
HOXA5 homeobox A5 -3.1857
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -2.41492
PCCB propionyl CoA carboxylase, beta polypeptide -2.29975
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.21518
GID8 GID complex subunit 8 -2.17425
PLAGL1 pleiomorphic adenoma gene-like 1 -2.15113
TRPS1 trichorhinophalangeal syndrome I -2.0663