CRCGN017_MCF10A.TP53.M_24H:L19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cyclosporin-a 97.79 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

542 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:L19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUCB2 nucleobindin 2 10.0
HBA1 hemoglobin, alpha 1 8.72204
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 8.0542
GFPT1 glutamine--fructose-6-phosphate transaminase 1 7.5214
GLRX glutaredoxin (thioltransferase) 6.68837
SLC35B1 solute carrier family 35, member B1 6.26515
AGR2 anterior gradient 2 6.23565
PYCR1 pyrroline-5-carboxylate reductase 1 6.20675
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 6.0938
CXCL2 chemokine (C-X-C motif) ligand 2 6.0797
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 5.78094
ASNS asparagine synthetase (glutamine-hydrolyzing) 5.3058
AARS1 alanyl-tRNA synthetase 1 5.2579
HBB hemoglobin, beta 5.20762
ECH1 enoyl CoA hydratase 1, peroxisomal 5.09585
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 5.0401
RPN1 ribophorin I 5.0172
PHGDH phosphoglycerate dehydrogenase 4.91525
PSAT1 phosphoserine aminotransferase 1 4.91375
UGDH UDP-glucose 6-dehydrogenase 4.89635
ATF4 activating transcription factor 4 4.7766
TRIB3 tribbles pseudokinase 3 4.5416
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 4.5298
TXNRD1 thioredoxin reductase 1 4.46585
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 4.3105
C2CD2 C2 calcium-dependent domain containing 2 4.25065
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 4.2382
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 4.187
SQSTM1 sequestosome 1 4.15893
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) 4.13198
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9 4.13088
NLRP4 NLR family, pyrin domain containing 4 4.1218
CTSL cathepsin L 4.06145
GARS1 glycyl-tRNA synthetase 1 3.99595
WFS1 Wolfram syndrome 1 (wolframin) 3.99365
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 3.93425
CREB3L2 cAMP responsive element binding protein 3-like 2 3.9324
CALU calumenin 3.88335
CARS1 cysteinyl-tRNA synthetase 1 3.87247
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.83775
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 3.81315
FICD FIC domain containing 3.79205
XPOT exportin, tRNA 3.7883
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 3.74895
HYOU1 hypoxia up-regulated 1 3.71975
COPB1 coatomer protein complex, subunit beta 1 3.7109
UFM1 ubiquitin-fold modifier 1 3.70325
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 3.60755
MANF mesencephalic astrocyte-derived neurotrophic factor 3.56795
TERF2IP telomeric repeat binding factor 2, interacting protein 3.52795
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 3.48675
RBP4 retinol binding protein 4, plasma 3.46245
EGR1 early growth response 1 3.44388
GOLGA3 golgin A3 3.427
USO1 USO1 vesicle transport factor 3.42237
VSIG2 V-set and immunoglobulin domain containing 2 3.41855
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) 3.41633
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 3.37508
SARAF store-operated calcium entry-associated regulatory factor 3.36555
FYN FYN proto-oncogene, Src family tyrosine kinase 3.34712
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 3.33682
FKBP14 FK506 binding protein 14, 22 kDa 3.30425
PGM3 phosphoglucomutase 3 3.25435
P3H1 prolyl 3-hydroxylase 1 3.2189
PRAF2 PRA1 domain family, member 2 3.21045
PDIA4 protein disulfide isomerase family A, member 4 3.2045
WARS1 tryptophanyl-tRNA synthetase 1 3.18582
CANX calnexin 3.12388
RCN1 reticulocalbin 1, EF-hand calcium binding domain 3.076
MARS1 methionyl-tRNA synthetase 1 3.04552
FKBP11 FK506 binding protein 11, 19 kDa 3.03382
ADAT1 adenosine deaminase, tRNA-specific 1 3.0089
TXNDC15 thioredoxin domain containing 15 3.0052
LOC128125814 uncharacterized LOC128125814 2.99585
SCCPDH saccharopine dehydrogenase (putative) 2.96675
ERLIN2 ER lipid raft associated 2 2.9266
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 2.91197
HDLBP high density lipoprotein binding protein 2.9106
SQOR sulfide quinone oxidoreductase 2.90655
HSPA13 heat shock protein 70kDa family, member 13 2.89488
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 2.88967
ATF6 activating transcription factor 6 2.8883
WIPI1 WD repeat domain, phosphoinositide interacting 1 2.8854
AKTIP AKT interacting protein 2.8841
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 2.87095
CERS2 ceramide synthase 2 2.868
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 2.86033
HAX1 HCLS1 associated protein X-1 2.85035
SARS1 seryl-tRNA synthetase 1 2.84355
PDIA5 protein disulfide isomerase family A, member 5 2.8402
KLHL21 kelch-like family member 21 2.84
NPIPB5 nuclear pore complex interacting protein family, member B5 2.83505
EPRS1 glutamyl-prolyl-tRNA synthetase 1 2.83387
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 2.8311
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 2.8231
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2 2.82015
TM9SF2 transmembrane 9 superfamily member 2 2.8169
AXIN1 axin 1 2.80785
TMEM260 transmembrane protein 260 2.80505
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 2.79955
TARS1 threonyl-tRNA synthetase 1 2.79865
TNIP1 TNFAIP3 interacting protein 1 2.78925
PDIA6 protein disulfide isomerase family A, member 6 2.7864
ELL2 elongation factor, RNA polymerase II, 2 2.78195
IARS1 isoleucyl-tRNA synthetase 1 2.7509
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12 2.74975
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 2.73695
SSR1 signal sequence receptor, alpha 2.73132
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 2.72615
ARFIP2 ADP-ribosylation factor interacting protein 2 2.7224
MAGT1 magnesium transporter 1 2.7176
UFL1 UFM1-specific ligase 1 2.71535
ARCN1 archain 1 2.66615
ACADVL acyl-CoA dehydrogenase, very long chain 2.63505
TMEM39A transmembrane protein 39A 2.6255
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 2.625
NARS1 asparaginyl-tRNA synthetase 1 2.62325
AOX1 aldehyde oxidase 1 2.61915
SRPRB signal recognition particle receptor, B subunit 2.577
MBNL2 muscleblind-like splicing regulator 2 2.57383
ASS1 argininosuccinate synthase 1 2.5695
CRELD2 cysteine-rich with EGF-like domains 2 2.56745
HMBOX1 homeobox containing 1 2.5519
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) 2.53905
LYPLA1-TCEA1 LYPLA1-TCEA1 readthrough 2.52305
P4HB prolyl 4-hydroxylase, beta polypeptide 2.51345
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 2.50115
LGMN legumain 2.49605
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 2.495
MMP24-AS1-EDEM2 MMP24-AS1-EDEM2 readthrough 2.49485
GRB10 growth factor receptor-bound protein 10 2.48975
GYPC glycophorin C (Gerbich blood group) 2.4844
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 2.4796
IER3 immediate early response 3 2.4755
HSPB6 heat shock protein, alpha-crystallin-related, B6 2.4701
SSR4 signal sequence receptor, delta 2.46795
DHRS7 dehydrogenase/reductase (SDR family) member 7 2.461
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma 2.46015
TM9SF3 transmembrane 9 superfamily member 3 2.45175
GLG1 golgi glycoprotein 1 2.44658
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 2.44515
DDIT4 DNA-damage-inducible transcript 4 2.4256
IL1B interleukin 1, beta 2.42172
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 2.4196
KDSR 3-ketodihydrosphingosine reductase 2.41815
ACO1 aconitase 1, soluble 2.40955
CXCL3 chemokine (C-X-C motif) ligand 3 2.40795
TRAM1 translocation associated membrane protein 1 2.40423
MORC4 MORC family CW-type zinc finger 4 2.40175
LIF leukemia inhibitory factor 2.3996
ALDH9A1 aldehyde dehydrogenase 9 family, member A1 2.38235
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 2.3772
HHIPL2 HHIP-like 2 2.37585
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 2.37115
COPG1 coatomer protein complex, subunit gamma 1 2.3576
RABAC1 Rab acceptor 1 (prenylated) 2.3573
SEC23B Sec23 homolog B (S. cerevisiae) 2.34948
ZNF862 zinc finger protein 862 2.33615
TCF7 transcription factor 7 (T-cell specific, HMG-box) 2.3357
CCNA1 cyclin A1 2.33275
RPN2 ribophorin II 2.33255
GAA glucosidase, alpha; acid 2.3281
TTC17 tetratricopeptide repeat domain 17 2.32335
SEC24D SEC24 family member D 2.31072
HMOX1 heme oxygenase 1 2.3077
RNF187 ring finger protein 187 2.30725
CAPRIN2 caprin family member 2 2.2923
CDC50A cell division cycle 50 P4-ATPase accessory subunit A 2.29205
NMRK1 nicotinamide riboside kinase 1 2.28775
ADAM9 ADAM metallopeptidase domain 9 2.2872
SEC63 SEC63 homolog (S. cerevisiae) 2.28473
ARB2A ARB2 cotranscriptional regulator A 2.2839
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 2.28375
SLC39A14 solute carrier family 39 (zinc transporter), member 14 2.2823
ALDH6A1 aldehyde dehydrogenase 6 family, member A1 2.27176
TMED7 transmembrane emp24 protein transport domain containing 7 2.26288
KIF21B kinesin family member 21B 2.25995
LOC114841035 uncharacterized LOC114841035 2.2569
TMEM45A transmembrane protein 45A 2.2519
RHOQ ras homolog family member Q 2.25043
SLC67A1 solute carrier family 67 member 1 2.25025
CCPG1 cell cycle progression 1 2.24844
OSGIN2 oxidative stress induced growth inhibitor family member 2 2.2461
CASP8AP2 caspase 8 associated protein 2 2.24375
PIGK phosphatidylinositol glycan anchor biosynthesis, class K 2.24325
MCUR1 mitochondrial calcium uniporter regulator 1 2.24105
FAM114A1 family with sequence similarity 114, member A1 2.23445
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.2293
ZNF410 zinc finger protein 410 2.21948
BRAF B-Raf proto-oncogene, serine/threonine kinase 2.2153
IL1A interleukin 1, alpha 2.21305
MID1IP1 MID1 interacting protein 1 2.2099
UXS1 UDP-glucuronate decarboxylase 1 2.2052
YIPF6 Yip1 domain family, member 6 2.20506
ZNF516 zinc finger protein 516 2.1994
EGR3 early growth response 3 2.1973
TMEM214 transmembrane protein 214 2.195
WRN Werner syndrome, RecQ helicase-like 2.19375
GHITM growth hormone inducible transmembrane protein 2.18932
TMEM208 transmembrane protein 208 2.1842
BET1 Bet1 golgi vesicular membrane trafficking protein 2.1791
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 2.1659
PPIB peptidylprolyl isomerase B (cyclophilin B) 2.16353
SCFD1 sec1 family domain containing 1 2.157
EIF2D eukaryotic translation initiation factor 2D 2.15695
DENND2D DENN/MADD domain containing 2D 2.15445
MYDGF myeloid-derived growth factor 2.14815
LY9 lymphocyte antigen 9 2.1371
UBASH3A ubiquitin associated and SH3 domain containing A 2.1304
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 2.1264
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 2.1257
MUTYH mutY homolog 2.12465
ITGA10 integrin, alpha 10 2.12385
SYNE3 spectrin repeat containing, nuclear envelope family member 3 2.11875
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 2.11611
ANKRD11 ankyrin repeat domain 11 2.11485
RETREG1 reticulophagy regulator 1 2.1121
SEC62 SEC62 homolog (S. cerevisiae) 2.10825
JTB jumping translocation breakpoint 2.1075
ADGRG2 adhesion G protein-coupled receptor G2 2.1059
SEC16A SEC16 homolog A (S. cerevisiae) 2.10435
TXLNA taxilin alpha 2.0962
MKNK2 MAP kinase interacting serine/threonine kinase 2 2.0932
SLC31A1 solute carrier family 31 (copper transporter), member 1 2.09085
CTBS chitobiase, di-N-acetyl- 2.08997
ANO10 anoctamin 10 2.0892
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 2.087
EEF1AKMT3 EEF1A lysine methyltransferase 3 2.0857
SSR2 signal sequence receptor, beta (translocon-associated protein beta) 2.08115
GCC2 GRIP and coiled-coil domain containing 2 2.0811
BLMH bleomycin hydrolase 2.08025
CA8 carbonic anhydrase VIII 2.08
G0S2 G0/G1 switch 2 2.0792
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene) 2.07697
IMPACT impact RWD domain protein 2.076
FCMR Fc fragment of IgM receptor 2.073
SIL1 SIL1 nucleotide exchange factor 2.0728
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4 2.0711
PTPRE protein tyrosine phosphatase, receptor type, E 2.06925
OLAH oleoyl-ACP hydrolase 2.06615
IGFBP4 insulin-like growth factor binding protein 4 2.0644
WWC3 WWC family member 3 2.0643
TMBIM6 transmembrane BAX inhibitor motif containing 6 2.06
LRP10 low density lipoprotein receptor-related protein 10 2.05965
SERP1 stress-associated endoplasmic reticulum protein 1 2.0587
TMED2 transmembrane emp24 domain trafficking protein 2 2.05562
ASB8 ankyrin repeat and SOCS box containing 8 2.054
ELF5 E74-like factor 5 (ets domain transcription factor) 2.04205
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 2.0419
NANS N-acetylneuraminic acid synthase 2.0404
AZIN2 antizyme inhibitor 2 2.0394
RBKS ribokinase 2.03145
YARS1 tyrosyl-tRNA synthetase 1 2.03145
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 2.03
ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase 2.02765
GORASP2 golgi reassembly stacking protein 2, 55kDa 2.027
GMPPA GDP-mannose pyrophosphorylase A 2.02315
PLAGL1 pleiomorphic adenoma gene-like 1 2.02268
BDKRB2 bradykinin receptor B2 2.02155
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.0199
TMEM254 transmembrane protein 254 2.0132
AGMAT agmatine ureohydrolase (agmatinase) 2.00815
SPCS2 signal peptidase complex subunit 2 homolog (S. cerevisiae) 2.0064
NIBAN1 niban apoptosis regulator 1 2.00462
PLPBP pyridoxal phosphate binding protein 2.00368
FZD10 frizzled class receptor 10 2.00095

decreased expression

Symbol Name Standardized Value
MRPL12 mitochondrial ribosomal protein L12 -6.74955
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -6.50365
HSPB1 heat shock 27kDa protein 1 -6.2531
TUBA4A tubulin, alpha 4a -5.60805
KIF20A kinesin family member 20A -5.43665
STMN1 stathmin 1 -5.333
PARP2 poly (ADP-ribose) polymerase 2 -5.3267
CAB39 calcium binding protein 39 -4.8982
GRWD1 glutamate-rich WD repeat containing 1 -4.7947
TRAPPC3 trafficking protein particle complex 3 -4.76653
BASP1 brain abundant, membrane attached signal protein 1 -4.66275
MSMO1 methylsterol monooxygenase 1 -4.21825
JMJD6 jumonji domain containing 6 -4.16325
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -4.0724
GTF2A2 general transcription factor IIA, 2, 12kDa -3.7277
NSDHL NAD(P) dependent steroid dehydrogenase-like -3.72042
SRSF2 serine/arginine-rich splicing factor 2 -3.65355
CBX1 chromobox homolog 1 -3.63305
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) -3.57305
TMEM160 transmembrane protein 160 -3.54685
S100A4 S100 calcium binding protein A4 -3.49135
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) -3.4477
CD320 CD320 molecule -3.3093
PRR15L proline rich 15-like -3.28655
PFN1 profilin 1 -3.27395
OXA1L oxidase (cytochrome c) assembly 1-like -3.26975
GPS1 G protein pathway suppressor 1 -3.237
ADRB2 adrenoceptor beta 2, surface -3.16105
TAF11 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa -3.1576
NUSAP1 nucleolar and spindle associated protein 1 -3.06165
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -2.976
YJU2 YJU2 splicing factor homolog -2.96495
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 -2.961
CCNB1 cyclin B1 -2.9511
RNF111 ring finger protein 111 -2.94395
BACE2 beta-site APP-cleaving enzyme 2 -2.93525
ATP5PO ATP synthase peripheral stalk subunit OSCP -2.9157
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.91205
AURKB aurora kinase B -2.8942
MVD mevalonate (diphospho) decarboxylase -2.8765
CCNB2 cyclin B2 -2.86465
ATG3 autophagy related 3 -2.86333
DCK deoxycytidine kinase -2.8609
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1 -2.85385
SS18L2 synovial sarcoma translocation gene on chromosome 18-like 2 -2.8206
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3 -2.81655
ARMC7 armadillo repeat containing 7 -2.8108
MRPL44 mitochondrial ribosomal protein L44 -2.79095
BORCS8 BLOC-1 related complex subunit 8 -2.79085
MRM3 mitochondrial rRNA methyltransferase 3 -2.77785
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 -2.77055
IP6K2 inositol hexakisphosphate kinase 2 -2.7704
MXRA7 matrix-remodelling associated 7 -2.76665
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5) -2.76005
BZW2 basic leucine zipper and W2 domains 2 -2.7409
KRT14 keratin 14, type I -2.7401
PGAM4 phosphoglycerate mutase family member 4 -2.7264
MRPS15 mitochondrial ribosomal protein S15 -2.7239
ADNP activity-dependent neuroprotector homeobox -2.7073
PMF1-BGLAP PMF1-BGLAP readthrough -2.69695
RALGDS ral guanine nucleotide dissociation stimulator -2.69625
MED28 mediator complex subunit 28 -2.6879
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -2.68663
CENPX centromere protein X -2.6759
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1 -2.6519
RTL10 retrotransposon Gag like 10 -2.63855
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 -2.62705
MED21 mediator complex subunit 21 -2.61618
MCM3 minichromosome maintenance complex component 3 -2.61375
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A -2.61275
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent) -2.60612
DGCR2 DiGeorge syndrome critical region gene 2 -2.58903
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12) -2.5857
SMNDC1 survival motor neuron domain containing 1 -2.58325
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8 -2.5756
RGS19 regulator of G-protein signaling 19 -2.5737
TSPAN6 tetraspanin 6 -2.57285
WRAP53 WD repeat containing, antisense to TP53 -2.5667
SAP30BP SAP30 binding protein -2.56515
CHD8 chromodomain helicase DNA binding protein 8 -2.55755
FAM32A family with sequence similarity 32, member A -2.55265
CRYZ crystallin, zeta (quinone reductase) -2.55225
ALDH1B1 aldehyde dehydrogenase 1 family, member B1 -2.54825
METTL17 methyltransferase like 17 -2.5372
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide -2.53715
CYCS cytochrome c, somatic -2.5332
NLRP2B NLR family pyrin domain containing 2B -2.53025
CLIC3 chloride intracellular channel 3 -2.52485
AMDHD2 amidohydrolase domain containing 2 -2.52135
PWP2 PWP2 periodic tryptophan protein homolog (yeast) -2.52
AOAH acyloxyacyl hydrolase (neutrophil) -2.51775
TICAM1 toll-like receptor adaptor molecule 1 -2.5096
ZNF574 zinc finger protein 574 -2.50265
FRG1 FSHD region gene 1 -2.49825
FAM53C family with sequence similarity 53, member C -2.4934
EXOSC9 exosome component 9 -2.48475
ABT1 activator of basal transcription 1 -2.4715
CHMP6 charged multivesicular body protein 6 -2.46225
STAP2 signal transducing adaptor family member 2 -2.4592
MYD88 myeloid differentiation primary response 88 -2.45815
CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa -2.4552
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast) -2.45405
DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 -2.44915
C1QBP complement component 1, q subcomponent binding protein -2.43337
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa -2.4273
DRC11 dynein regulatory complex subunit 11 -2.42425
MTMR14 myotubularin related protein 14 -2.42335
GRN granulin -2.41668
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.4145
MOCS3 molybdenum cofactor synthesis 3 -2.4142
RAB5C RAB5C, member RAS oncogene family -2.41155
FEN1 flap structure-specific endonuclease 1 -2.41007
SRSF3 serine/arginine-rich splicing factor 3 -2.40845
CCNA2 cyclin A2 -2.40057
CEP131 centrosomal protein 131kDa -2.39815
CENPM centromere protein M -2.38845
ANXA2 annexin A2 -2.38455
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -2.38165
CDC45 cell division cycle 45 -2.37375
TPPP tubulin polymerization promoting protein -2.37325
OSGEP O-sialoglycoprotein endopeptidase -2.36425
H2BC12 H2B clustered histone 12 -2.36132
MEX3D mex-3 RNA binding family member D -2.3612
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 -2.35753
RFC3 replication factor C (activator 1) 3, 38kDa -2.3566
CLTA clathrin, light chain A -2.35477
INCENP inner centromere protein antigens 135/155kDa -2.352
HAT1 histone acetyltransferase 1 -2.35195
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.35087
COPS7B COP9 signalosome subunit 7B -2.3477
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa -2.34045
HOXA4 homeobox A4 -2.3372
AMBRA1 autophagy/beclin-1 regulator 1 -2.32865
PRPF31 pre-mRNA processing factor 31 -2.3283
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 -2.32825
ZNF394 zinc finger protein 394 -2.30485
MRPS17 mitochondrial ribosomal protein S17 -2.2939
EIF4E2 eukaryotic translation initiation factor 4E family member 2 -2.29252
TMEM11 transmembrane protein 11 -2.287
FAAP100 FA core complex associated protein 100 -2.2865
BIRC5 baculoviral IAP repeat containing 5 -2.28603
NUP160 nucleoporin 160kDa -2.28038
ZNF274 zinc finger protein 274 -2.27975
SP2 Sp2 transcription factor -2.27555
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -2.26787
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 -2.2656
SNRNP35 small nuclear ribonucleoprotein 35kDa (U11/U12) -2.2643
CKS2 CDC28 protein kinase regulatory subunit 2 -2.2572
SMYD3 SET and MYND domain containing 3 -2.25475
PCYT2 phosphate cytidylyltransferase 2, ethanolamine -2.25355
MVP major vault protein -2.2502
MRPS2 mitochondrial ribosomal protein S2 -2.2477
COA3 cytochrome c oxidase assembly factor 3 -2.24625
HOXC4 homeobox C4 -2.2443
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -2.24008
SETMAR SET domain and mariner transposase fusion gene -2.2353
HDAC2 histone deacetylase 2 -2.231
GALK1 galactokinase 1 -2.2303
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 -2.2273
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A -2.2266
RNF138 ring finger protein 138, E3 ubiquitin protein ligase -2.22652
POLR2F polymerase (RNA) II (DNA directed) polypeptide F -2.22265
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae) -2.2206
KRT15 keratin 15, type I -2.2201
SNIP1 Smad nuclear interacting protein 1 -2.21935
EHMT1 euchromatic histone-lysine N-methyltransferase 1 -2.21845
ZDHHC13 zinc finger, DHHC-type containing 13 -2.21845
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -2.2159
RASSF7 Ras association (RalGDS/AF-6) domain family (N-terminal) member 7 -2.21252
ELOVL6 ELOVL fatty acid elongase 6 -2.2106
UMPS uridine monophosphate synthetase -2.20495
DNM1 dynamin 1 -2.20135
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta -2.19975
H1-2 H1.2 linker histone, cluster member -2.19955
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast) -2.1979
COG7 component of oligomeric golgi complex 7 -2.1969
CFAP298 cilia and flagella associated protein 298 -2.19565
KCNK5 potassium channel, two pore domain subfamily K, member 5 -2.19375
TK1 thymidine kinase 1, soluble -2.1926
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa -2.1879
DUSP2 dual specificity phosphatase 2 -2.18765
GTPBP8 GTP-binding protein 8 (putative) -2.18685
ZMYM1 zinc finger, MYM-type 1 -2.1809
DAPK3 death-associated protein kinase 3 -2.18075
HSPH1 heat shock 105kDa/110kDa protein 1 -2.1806
RGS2 regulator of G-protein signaling 2 -2.1769
LMBR1 limb development membrane protein 1 -2.17508
NCS1 neuronal calcium sensor 1 -2.17325
WDCP WD repeat and coiled coil containing -2.1709
TGIF2 TGFB-induced factor homeobox 2 -2.1686
APOA4 apolipoprotein A-IV -2.1615
ZNF185 zinc finger protein 185 (LIM domain) -2.16145
NDUFA8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa -2.15915
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae) -2.15745
NT5C 5', 3'-nucleotidase, cytosolic -2.15725
POLA2 polymerase (DNA directed), alpha 2, accessory subunit -2.15305
ATP5F1D ATP synthase F1 subunit delta -2.14705
H2BC9 H2B clustered histone 9 -2.14635
ZNF248 zinc finger protein 248 -2.14515
BEND5 BEN domain containing 5 -2.14145
NUP107 nucleoporin 107kDa -2.1389
NFYA nuclear transcription factor Y, alpha -2.13795
LARP7 La ribonucleoprotein domain family, member 7 -2.1342
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 -2.13303
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2 -2.12899
ASB6 ankyrin repeat and SOCS box containing 6 -2.1266
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 -2.1244
UBL5 ubiquitin-like 5 -2.12245
NOL11 nucleolar protein 11 -2.1215
EXOSC4 exosome component 4 -2.1195
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) -2.1188
KDM1A lysine (K)-specific demethylase 1A -2.11825
PRC1 protein regulator of cytokinesis 1 -2.11505
THOC6 THO complex 6 -2.11355
MRPL9 mitochondrial ribosomal protein L9 -2.11145
LRP3 low density lipoprotein receptor-related protein 3 -2.11115
PPP4C protein phosphatase 4, catalytic subunit -2.10795
SFXN3 sideroflexin 3 -2.10705
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) -2.10672
MFAP1 microfibrillar-associated protein 1 -2.1036
BCAS2 breast carcinoma amplified sequence 2 -2.10255
NXT1 nuclear transport factor 2-like export factor 1 -2.0988
COPS4 COP9 signalosome subunit 4 -2.0969
POLR2H polymerase (RNA) II (DNA directed) polypeptide H -2.09625
DNAAF2 dynein, axonemal, assembly factor 2 -2.0959
INTS12 integrator complex subunit 12 -2.09225
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.09145
CDKN2AIP CDKN2A interacting protein -2.086
ENG endoglin -2.08455
OXLD1 oxidoreductase-like domain containing 1 -2.0816
SMIM8 small integral membrane protein 8 -2.08035
SSNA1 Sjogren syndrome nuclear autoantigen 1 -2.07905
ESRP2 epithelial splicing regulatory protein 2 -2.07815
CLN3 ceroid-lipofuscinosis, neuronal 3 -2.07608
UBP1 upstream binding protein 1 (LBP-1a) -2.0742
TPGS1 tubulin polyglutamylase complex subunit 1 -2.07245
OIP5 Opa interacting protein 5 -2.0708
TP53I3 tumor protein p53 inducible protein 3 -2.07075
CCT8 chaperonin containing TCP1, subunit 8 (theta) -2.06995
CPNE3 copine III -2.06612
CCNF cyclin F -2.06455
TIAM1 T-cell lymphoma invasion and metastasis 1 -2.06337
FLNA filamin A, alpha -2.05925
CDK1 cyclin-dependent kinase 1 -2.05707
QTRT1 queuine tRNA-ribosyltransferase 1 -2.04955
CISD1 CDGSH iron sulfur domain 1 -2.04425
GMNN geminin, DNA replication inhibitor -2.04415
TYROBP TYRO protein tyrosine kinase binding protein -2.0435
KBTBD4 kelch repeat and BTB (POZ) domain containing 4 -2.03895
KLK8 kallikrein-related peptidase 8 -2.0387
USP5 ubiquitin specific peptidase 5 (isopeptidase T) -2.0364
SNRPC small nuclear ribonucleoprotein polypeptide C -2.03525
NASP nuclear autoantigenic sperm protein (histone-binding) -2.03425
RBM15B RNA binding motif protein 15B -2.0336
COMMD9 COMM domain containing 9 -2.0321
MCM5 minichromosome maintenance complex component 5 -2.02983
SNCG synuclein, gamma (breast cancer-specific protein 1) -2.02865
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -2.02685
FN3KRP fructosamine 3 kinase related protein -2.02575
CS citrate synthase -2.0234
IPO8 importin 8 -2.0201
CEP15 centrosomal protein 15 -2.0172
WDR77 WD repeat domain 77 -2.01555
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa -2.0152
CDR2L cerebellar degeneration-related protein 2-like -2.015
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A -2.0147
TRA2B transformer 2 beta homolog (Drosophila) -2.01133
MYLIP myosin regulatory light chain interacting protein -2.0064
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha -2.0051
CCDC134 coiled-coil domain containing 134 -2.00485
STK25 serine/threonine kinase 25 -2.00485
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -2.00402
SDC1 syndecan 1 -2.00385
LAG3 lymphocyte-activation gene 3 -2.00385
RRP1B ribosomal RNA processing 1B -2.00215
GPRC5C G protein-coupled receptor, class C, group 5, member C -2.002