CRCGN017_MCF10A.TP53.M_24H:L21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cyclosporin-a 10.87 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

286 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:L21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUCB2 nucleobindin 2 8.9093
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 7.85545
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 7.46128
GLRX glutaredoxin (thioltransferase) 5.97575
PYCR1 pyrroline-5-carboxylate reductase 1 5.25325
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 5.23305
GFPT1 glutamine--fructose-6-phosphate transaminase 1 5.06275
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 5.0553
SLC35B1 solute carrier family 35, member B1 4.8626
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.84925
CXCL2 chemokine (C-X-C motif) ligand 2 4.82185
PHGDH phosphoglycerate dehydrogenase 4.7378
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 4.5222
ASNS asparagine synthetase (glutamine-hydrolyzing) 4.51035
AARS1 alanyl-tRNA synthetase 1 4.3624
WFS1 Wolfram syndrome 1 (wolframin) 4.3592
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 4.26105
TRIB3 tribbles pseudokinase 3 4.25945
ATF4 activating transcription factor 4 4.24905
PSAT1 phosphoserine aminotransferase 1 4.24775
GARS1 glycyl-tRNA synthetase 1 4.1115
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) 3.85048
RPN1 ribophorin I 3.7921
CARS1 cysteinyl-tRNA synthetase 1 3.7536
SARS1 seryl-tRNA synthetase 1 3.74825
P3H1 prolyl 3-hydroxylase 1 3.66065
NLRP4 NLR family, pyrin domain containing 4 3.6483
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 3.49035
HYOU1 hypoxia up-regulated 1 3.4679
SQSTM1 sequestosome 1 3.46132
UGDH UDP-glucose 6-dehydrogenase 3.42875
ECH1 enoyl CoA hydratase 1, peroxisomal 3.3253
AMDHD2 amidohydrolase domain containing 2 3.29805
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 3.2911
GMPPA GDP-mannose pyrophosphorylase A 3.27525
PDIA5 protein disulfide isomerase family A, member 5 3.26735
XPOT exportin, tRNA 3.2459
PDIA6 protein disulfide isomerase family A, member 6 3.24188
LOC128125814 uncharacterized LOC128125814 3.20465
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 3.18325
CALU calumenin 3.1503
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9 3.09648
FICD FIC domain containing 2.99065
SIL1 SIL1 nucleotide exchange factor 2.97725
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) 2.97627
TMEM39A transmembrane protein 39A 2.96605
LOC102724560 cystathionine beta-synthase 2.9632
FYN FYN proto-oncogene, Src family tyrosine kinase 2.93472
PRAF2 PRA1 domain family, member 2 2.9262
CTSL cathepsin L 2.91145
HSPA13 heat shock protein 70kDa family, member 13 2.8943
GOLGA3 golgin A3 2.8674
TNIP1 TNFAIP3 interacting protein 1 2.8545
YARS1 tyrosyl-tRNA synthetase 1 2.84665
CKAP4 cytoskeleton-associated protein 4 2.84583
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 2.81225
MARS1 methionyl-tRNA synthetase 1 2.79988
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 2.78913
TXNRD1 thioredoxin reductase 1 2.78605
AGR2 anterior gradient 2 2.77215
RNF187 ring finger protein 187 2.7678
TXNDC15 thioredoxin domain containing 15 2.7559
GPATCH8 G patch domain containing 8 2.7358
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 2.73195
GADD45A growth arrest and DNA-damage-inducible, alpha 2.7056
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 2.6755
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 2.6612
PDIA4 protein disulfide isomerase family A, member 4 2.65368
P4HB prolyl 4-hydroxylase, beta polypeptide 2.62345
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 2.5941
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma 2.59115
CXCL3 chemokine (C-X-C motif) ligand 3 2.5907
S100A12 S100 calcium binding protein A12 2.56875
CCPG1 cell cycle progression 1 2.56336
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.55525
MED8 mediator complex subunit 8 2.54328
TM9SF2 transmembrane 9 superfamily member 2 2.5329
NARS1 asparaginyl-tRNA synthetase 1 2.51435
TMEM214 transmembrane protein 214 2.51095
BABAM2 BRISC and BRCA1 A complex member 2 2.49962
CRELD2 cysteine-rich with EGF-like domains 2 2.4865
HAX1 HCLS1 associated protein X-1 2.4852
WARS1 tryptophanyl-tRNA synthetase 1 2.4831
SEC63 SEC63 homolog (S. cerevisiae) 2.48235
SSR4 signal sequence receptor, delta 2.4777
RPN2 ribophorin II 2.46957
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 2.44995
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 2.44793
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 2.44517
PIGK phosphatidylinositol glycan anchor biosynthesis, class K 2.4449
ACTMAP actin maturation protease 2.4383
NFE2L1 nuclear factor, erythroid 2-like 1 2.41702
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 2.4165
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.41295
CXCL14 chemokine (C-X-C motif) ligand 14 2.39725
WIPI1 WD repeat domain, phosphoinositide interacting 1 2.39298
LYPLA1-TCEA1 LYPLA1-TCEA1 readthrough 2.38905
USO1 USO1 vesicle transport factor 2.38828
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 2.3837
CIRBP cold inducible RNA binding protein 2.36425
ALG11 ALG11, alpha-1,2-mannosyltransferase 2.36175
VSIG2 V-set and immunoglobulin domain containing 2 2.36107
GLG1 golgi glycoprotein 1 2.35432
MYDGF myeloid-derived growth factor 2.34342
COLGALT2 collagen beta(1-O)galactosyltransferase 2 2.34155
GAA glucosidase, alpha; acid 2.3395
CREB3L2 cAMP responsive element binding protein 3-like 2 2.32995
TM9SF3 transmembrane 9 superfamily member 3 2.3225
ZCCHC8 zinc finger, CCHC domain containing 8 2.29135
RABAC1 Rab acceptor 1 (prenylated) 2.29075
DDR2 discoidin domain receptor tyrosine kinase 2 2.2884
TERF2IP telomeric repeat binding factor 2, interacting protein 2.27905
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 2.27638
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 2.26885
APMAP adipocyte plasma membrane associated protein 2.2561
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 2.2531
IARS1 isoleucyl-tRNA synthetase 1 2.23745
SLC39A14 solute carrier family 39 (zinc transporter), member 14 2.2359
UFM1 ubiquitin-fold modifier 1 2.23185
MANF mesencephalic astrocyte-derived neurotrophic factor 2.2251
HAPLN1 hyaluronan and proteoglycan link protein 1 2.21907
MMP24-AS1-EDEM2 MMP24-AS1-EDEM2 readthrough 2.2097
CDK5RAP3 CDK5 regulatory subunit associated protein 3 2.204
SARAF store-operated calcium entry-associated regulatory factor 2.2005
IQCB1 IQ motif containing B1 2.19583
ANKZF1 ankyrin repeat and zinc finger domain containing 1 2.19355
COPB1 coatomer protein complex, subunit beta 1 2.18937
CEP63 centrosomal protein 63kDa 2.1873
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 2.1864
SCCPDH saccharopine dehydrogenase (putative) 2.18407
CANX calnexin 2.18292
SSR1 signal sequence receptor, alpha 2.17427
MID1IP1 MID1 interacting protein 1 2.16805
TXNDC5 thioredoxin domain containing 5 (endoplasmic reticulum) 2.16095
HDLBP high density lipoprotein binding protein 2.14895
CRAT carnitine O-acetyltransferase 2.1351
GORASP2 golgi reassembly stacking protein 2, 55kDa 2.13295
CPT1B carnitine palmitoyltransferase 1B (muscle) 2.12932
JTB jumping translocation breakpoint 2.12297
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 2.1218
MOGS mannosyl-oligosaccharide glucosidase 2.1182
KIF21B kinesin family member 21B 2.10955
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) 2.10285
HSPA9 heat shock 70kDa protein 9 (mortalin) 2.10007
AKTIP AKT interacting protein 2.09965
EMC7 ER membrane protein complex subunit 7 2.09155
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1 2.08825
BHLHE41 basic helix-loop-helix family, member e41 2.0664
YIF1A Yip1 interacting factor homolog A (S. cerevisiae) 2.06465
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.0645
AGA aspartylglucosaminidase 2.05827
RAP1GAP RAP1 GTPase activating protein 2.03305
TWF2 twinfilin actin binding protein 2 2.02595
GBA1 glucosylceramidase beta 1 2.02433
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent) 2.01745
FNDC3B fibronectin type III domain containing 3B 2.0172
FCGBP Fc fragment of IgG binding protein 2.00195

decreased expression

Symbol Name Standardized Value
ANXA2 annexin A2 -6.10258
HSPB1 heat shock 27kDa protein 1 -5.8154
TUBB6 tubulin, beta 6 class V -5.72375
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -5.5614
DYNLT3 dynein, light chain, Tctex-type 3 -5.1347
STMN1 stathmin 1 -5.0546
GRWD1 glutamate-rich WD repeat containing 1 -5.03305
DCK deoxycytidine kinase -4.8051
CDC45 cell division cycle 45 -4.7485
DIPK1A divergent protein kinase domain 1A -4.54273
MSMO1 methylsterol monooxygenase 1 -4.1596
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -3.81107
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -3.6585
UBE3C ubiquitin protein ligase E3C -3.45505
CYCS cytochrome c, somatic -3.2697
S100A4 S100 calcium binding protein A4 -3.2257
BACE2 beta-site APP-cleaving enzyme 2 -3.21255
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -3.2108
ATG3 autophagy related 3 -3.17958
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -3.15155
ADRB2 adrenoceptor beta 2, surface -3.11865
GTF2A2 general transcription factor IIA, 2, 12kDa -3.0616
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.01345
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.95675
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.86478
SYTL2 synaptotagmin-like 2 -2.8529
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) -2.7228
TUBB4B tubulin, beta 4B class IVb -2.70428
TRIP13 thyroid hormone receptor interactor 13 -2.67805
NLRP2B NLR family pyrin domain containing 2B -2.67735
MRPL12 mitochondrial ribosomal protein L12 -2.66965
MYD88 myeloid differentiation primary response 88 -2.64515
CPNE3 copine III -2.62797
CHODL chondrolectin -2.6152
C1QBP complement component 1, q subcomponent binding protein -2.60472
IL18 interleukin 18 -2.60075
BID BH3 interacting domain death agonist -2.58133
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -2.57915
ELOVL6 ELOVL fatty acid elongase 6 -2.57095
ESRP2 epithelial splicing regulatory protein 2 -2.5651
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -2.55615
PSRC1 proline/serine-rich coiled-coil 1 -2.53885
EGLN2 egl-9 family hypoxia-inducible factor 2 -2.52675
VDAC3 voltage-dependent anion channel 3 -2.5189
ZNF274 zinc finger protein 274 -2.5176
PLSCR1 phospholipid scramblase 1 -2.5014
GTPBP8 GTP-binding protein 8 (putative) -2.49715
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta -2.49405
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.49325
CCT2 chaperonin containing TCP1, subunit 2 (beta) -2.48495
ZNF35 zinc finger protein 35 -2.46415
CRYZ crystallin, zeta (quinone reductase) -2.4516
CCDC6 coiled-coil domain containing 6 -2.435
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -2.4133
HDAC2 histone deacetylase 2 -2.4028
SMNDC1 survival motor neuron domain containing 1 -2.3926
SRSF3 serine/arginine-rich splicing factor 3 -2.38208
MACF1 microtubule-actin crosslinking factor 1 -2.37999
HOXC4 homeobox C4 -2.3777
HNRNPF heterogeneous nuclear ribonucleoprotein F -2.36425
HAT1 histone acetyltransferase 1 -2.3634
YAP1 Yes-associated protein 1 -2.3546
COMMD8 COMM domain containing 8 -2.3317
PRR15L proline rich 15-like -2.33065
RPA3 replication protein A3, 14kDa -2.3305
TWF1 twinfilin actin binding protein 1 -2.3243
SGMS1 sphingomyelin synthase 1 -2.30055
BASP1 brain abundant, membrane attached signal protein 1 -2.299
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 -2.29855
GMNN geminin, DNA replication inhibitor -2.29513
PNRC2 proline-rich nuclear receptor coactivator 2 -2.2943
SS18L2 synovial sarcoma translocation gene on chromosome 18-like 2 -2.2863
ADI1 acireductone dioxygenase 1 -2.27515
EPCAM epithelial cell adhesion molecule -2.26555
SDHAF3 succinate dehydrogenase complex assembly factor 3 -2.26365
PGAM4 phosphoglycerate mutase family member 4 -2.2428
ALDOC aldolase C, fructose-bisphosphate -2.24075
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 -2.2351
REEP1 receptor accessory protein 1 -2.23327
HLA-F major histocompatibility complex, class I, F -2.23052
TAGLN2 transgelin 2 -2.22913
BATF3 basic leucine zipper transcription factor, ATF-like 3 -2.21985
GADD45B growth arrest and DNA-damage-inducible, beta -2.218
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha -2.2131
VGLL3 vestigial-like family member 3 -2.21065
MYCBP MYC binding protein -2.20975
MCM3 minichromosome maintenance complex component 3 -2.2066
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 -2.20645
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 -2.20445
ACTR3B ARP3 actin-related protein 3 homolog B (yeast) -2.19605
HMGN4 high mobility group nucleosomal binding domain 4 -2.18923
SETMAR SET domain and mariner transposase fusion gene -2.18
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) -2.16355
TMEM14A transmembrane protein 14A -2.16185
CISD1 CDGSH iron sulfur domain 1 -2.1527
ZNF134 zinc finger protein 134 -2.14695
HMGN1 high mobility group nucleosome binding domain 1 -2.1423
MARCO macrophage receptor with collagenous structure -2.14075
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -2.13245
FEN1 flap structure-specific endonuclease 1 -2.12822
RACGAP1 Rac GTPase activating protein 1 -2.12235
OIP5 Opa interacting protein 5 -2.1189
GPRC5A G protein-coupled receptor, class C, group 5, member A -2.11442
CPB1 carboxypeptidase B1 (tissue) -2.0954
NUTF2 nuclear transport factor 2 -2.0787
PRPF4 pre-mRNA processing factor 4 -2.07667
ALDH1B1 aldehyde dehydrogenase 1 family, member B1 -2.06642
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast) -2.0638
TSPAN6 tetraspanin 6 -2.05585
MRPL44 mitochondrial ribosomal protein L44 -2.05555
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -2.0545
MED17 mediator complex subunit 17 -2.0523
CALM2 calmodulin 2 (phosphorylase kinase, delta) -2.04865
UBL5 ubiquitin-like 5 -2.048
NSMCE4A non-SMC element 4 homolog A (S. cerevisiae) -2.04708
RTL10 retrotransposon Gag like 10 -2.0431
RAD21 RAD21 homolog (S. pombe) -2.04245
POLR2H polymerase (RNA) II (DNA directed) polypeptide H -2.0421
TAF11 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa -2.03495
UFD1 ubiquitin recognition factor in ER associated degradation 1 -2.0334
HYAL2 hyaluronoglucosaminidase 2 -2.0325
TMSB10 thymosin beta 10 -2.03215
PGCKA1 PDCD10 and GCKIII kinases associated 1 -2.02455
TFCP2L1 transcription factor CP2-like 1 -2.01815
PADI3 peptidyl arginine deiminase, type III -2.01395
FRK fyn-related Src family tyrosine kinase -2.0132
HMGB3 high mobility group box 3 -2.0083
SUMO4 small ubiquitin-like modifier 4 -2.0029
RASSF7 Ras association (RalGDS/AF-6) domain family (N-terminal) member 7 -2.00115