CRCGN017_MCF10A.TP53.M_24H:L24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sulforaphane 10.87 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

65 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:L24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 5.01565
GFOD1 glucose-fructose oxidoreductase domain containing 1 4.97332
HYOU1 hypoxia up-regulated 1 4.95755
SSBP2 single-stranded DNA binding protein 2 4.82629
STAP2 signal transducing adaptor family member 2 4.59023
GRB10 growth factor receptor-bound protein 10 3.59148
FGFR4 fibroblast growth factor receptor 4 3.42637
SPAG4 sperm associated antigen 4 3.10885
NOTCH1 notch 1 2.95441
ZNF432 zinc finger protein 432 2.85293
RAP1GAP RAP1 GTPase activating protein 2.75517
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 2.65221
WASHC5 WASH complex subunit 5 2.63532
GSTT1 glutathione S-transferase theta 1 2.62855
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.57847
TRAPPC4 trafficking protein particle complex 4 2.48169
ANO10 anoctamin 10 2.4226
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 2.31492
CXCR4 chemokine (C-X-C motif) receptor 4 2.25774
E2F2 E2F transcription factor 2 2.22055
EIF4H eukaryotic translation initiation factor 4H 2.21122
ADO 2-aminoethanethiol (cysteamine) dioxygenase 2.16272
COQ8A coenzyme Q8A 2.15085
PLCB4 phospholipase C, beta 4 2.13716
CCT7 chaperonin containing TCP1, subunit 7 (eta) 2.11403
KRT18 keratin 18, type I 2.10524
AGR2 anterior gradient 2 2.0842
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) 2.04473
RBBP5 retinoblastoma binding protein 5 2.04415
GPX3 glutathione peroxidase 3 2.03019
RPS25 ribosomal protein S25 2.02946

decreased expression

Symbol Name Standardized Value
COG2 component of oligomeric golgi complex 2 -4.96396
GTPBP8 GTP-binding protein 8 (putative) -4.82594
LDHD lactate dehydrogenase D -3.33161
KRT14 keratin 14, type I -3.07079
SLC25A46 solute carrier family 25, member 46 -3.06734
COQ9 coenzyme Q9 -3.06329
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.78497
CRYZL1 crystallin, zeta (quinone reductase)-like 1 -2.76063
BASP1 brain abundant, membrane attached signal protein 1 -2.61899
TTC13 tetratricopeptide repeat domain 13 -2.55392
PSME3IP1 proteasome activator subunit 3 interacting protein 1 -2.54043
UNC119 unc-119 homolog (C. elegans) -2.46433
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -2.41927
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.41505
NIPSNAP2 nipsnap homolog 2 -2.4139
HCK HCK proto-oncogene, Src family tyrosine kinase -2.347
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1 -2.32837
LAIR2 leukocyte-associated immunoglobulin-like receptor 2 -2.24174
CDC7 cell division cycle 7 -2.23946
ANXA1 annexin A1 -2.20096
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 -2.1729
TES testin LIM domain protein -2.17111
SH2D2A SH2 domain containing 2A -2.13771
PLSCR4 phospholipid scramblase 4 -2.12295
TCEAL9 transcription elongation factor A like 9 -2.11047
CAV2 caveolin 2 -2.10108
GALT galactose-1-phosphate uridylyltransferase -2.09414
IL11RA interleukin 11 receptor, alpha -2.0614
SLC35A5 solute carrier family 35, member A5 -2.05784
ZNHIT6 zinc finger, HIT-type containing 6 -2.02007
MAN1C1 mannosidase, alpha, class 1C, member 1 -2.01604
MGST3 microsomal glutathione S-transferase 3 -2.01452
COG5 component of oligomeric golgi complex 5 -2.00473
DUS4L dihydrouridine synthase 4-like (S. cerevisiae) -2.0024