CRCGN017_MCF10A.TP53.M_24H:M06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,4-diaminoanisole sulfate 11.37 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

162 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:M06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 5.45186
TBPL1 TBP-like 1 5.26793
COMP cartilage oligomeric matrix protein 5.0
HBA1 hemoglobin, alpha 1 4.91089
NUP153 nucleoporin 153kDa 3.8119
TBX2 T-box 2 3.51515
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 3.46639
RBP4 retinol binding protein 4, plasma 3.38525
HBB hemoglobin, beta 3.25733
RNF111 ring finger protein 111 3.24179
CDCA4 cell division cycle associated 4 3.16733
THOC1 THO complex 1 2.9903
COXFA4L2 cytochrome c oxidase hypoxia associated subunit FA4L2 2.97122
WDR91 WD repeat domain 91 2.96569
BPGM 2,3-bisphosphoglycerate mutase 2.92197
NUP205 nucleoporin 205kDa 2.85668
CYREN cell cycle regulator of NHEJ 2.74209
VWA1 von Willebrand factor A domain containing 1 2.63848
MFSD1 major facilitator superfamily domain containing 1 2.6335
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.57802
PCYT2 phosphate cytidylyltransferase 2, ethanolamine 2.54204
ZNF107 zinc finger protein 107 2.50756
RHEX regulator of hemoglobinization and erythroid cell expansion 2.49702
CNRIP1 cannabinoid receptor interacting protein 1 2.46182
ZNF175 zinc finger protein 175 2.41845
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 2.40822
NRXN2 neurexin 2 2.40544
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like 2.38659
MGP matrix Gla protein 2.37515
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 2.36732
ADAMTSL4 ADAMTS-like 4 2.36537
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1 2.35369
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 2.34953
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1 2.34817
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 2.33215
IL7 interleukin 7 2.32198
AHDC1 AT hook, DNA binding motif, containing 1 2.30687
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 2.30454
KPNA5 karyopherin alpha 5 (importin alpha 6) 2.29934
BARD1 BRCA1 associated RING domain 1 2.28887
VLDLR very low density lipoprotein receptor 2.27201
LRRC61 leucine rich repeat containing 61 2.26115
GPATCH1 G patch domain containing 1 2.25133
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 2.22616
NYNRIN NYN domain and retroviral integrase containing 2.21939
GOSR1 golgi SNAP receptor complex member 1 2.20128
EFHD1 EF-hand domain family, member D1 2.20005
NRG2 neuregulin 2 2.17515
ZMYM6 zinc finger, MYM-type 6 2.16719
CCDC102B coiled-coil domain containing 102B 2.13632
KRT19 keratin 19, type I 2.13524
VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae) 2.13088
EBAG9 estrogen receptor binding site associated, antigen, 9 2.13027
ASCC2 activating signal cointegrator 1 complex subunit 2 2.12319
SOD3 superoxide dismutase 3, extracellular 2.11818
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.11814
MAB21L4 mab-21 like 4 2.11587
FAM184A family with sequence similarity 184, member A 2.11358
ASXL2 additional sex combs like transcriptional regulator 2 2.11302
GDF7 growth differentiation factor 7 2.11271
NPC1L1 NPC1-like 1 2.11257
CFI complement factor I 2.11078
ZNF512B zinc finger protein 512B 2.10586
CNOT4 CCR4-NOT transcription complex, subunit 4 2.10129
CPNE2 copine II 2.09508
ZNF232 zinc finger protein 232 2.08374
ZNF34 zinc finger protein 34 2.08362
MAPT microtubule-associated protein tau 2.0831
CA9 carbonic anhydrase IX 2.07942
TLR4 toll-like receptor 4 2.07901
WDR45B WD repeat domain 45B 2.07593
ACTR3B ARP3 actin-related protein 3 homolog B (yeast) 2.07511
HIRIP3 HIRA interacting protein 3 2.06678
MYT1L myelin transcription factor 1-like 2.06406
FABP6 fatty acid binding protein 6, ileal 2.06094
HILPDA hypoxia inducible lipid droplet-associated 2.05944
SLC35F6 solute carrier family 35, member F6 2.05817
CD200 CD200 molecule 2.04929
DGKG diacylglycerol kinase, gamma 90kDa 2.04351
SCRG1 stimulator of chondrogenesis 1 2.04248
MBNL3 muscleblind-like splicing regulator 3 2.03605
NPTN neuroplastin 2.02738
TRIM26 tripartite motif containing 26 2.01235
DUSP9 dual specificity phosphatase 9 2.00852
SCAF8 SR-related CTD-associated factor 8 2.00558
SERPINB10 serpin peptidase inhibitor, clade B (ovalbumin), member 10 2.00403
LGMN legumain 2.00291

decreased expression

Symbol Name Standardized Value
HMG20B high mobility group 20B -6.71667
BASP1 brain abundant, membrane attached signal protein 1 -6.16132
ACOT9 acyl-CoA thioesterase 9 -5.76511
HAT1 histone acetyltransferase 1 -5.52667
CDC25B cell division cycle 25B -4.92517
CRK v-crk avian sarcoma virus CT10 oncogene homolog -4.9022
MRPS2 mitochondrial ribosomal protein S2 -4.62805
MSN moesin -4.44625
PRDX4 peroxiredoxin 4 -3.71208
CRTAP cartilage associated protein -3.48296
PAEP progestagen-associated endometrial protein -3.47968
REEP5 receptor accessory protein 5 -3.19789
LOC127933115 uncharacterized LOC127933115 -3.19163
LDHD lactate dehydrogenase D -3.15216
MRPS16 mitochondrial ribosomal protein S16 -2.98157
EMC6 ER membrane protein complex subunit 6 -2.94175
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 -2.86048
ATF5 activating transcription factor 5 -2.85826
CD320 CD320 molecule -2.83187
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide -2.71479
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor -2.62212
RAB9A RAB9A, member RAS oncogene family -2.61756
APOO apolipoprotein O -2.60261
PFKM phosphofructokinase, muscle -2.53983
FSTL1 follistatin-like 1 -2.53332
LSM8 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.50526
RPL10A ribosomal protein L10a -2.49701
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast) -2.45748
MTMR11 myotubularin related protein 11 -2.45134
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing -2.4417
MRM3 mitochondrial rRNA methyltransferase 3 -2.43565
MAP3K3 mitogen-activated protein kinase kinase kinase 3 -2.43128
CUEDC2 CUE domain containing 2 -2.41449
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -2.40671
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -2.40312
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2 -2.39508
DHTKD1 dehydrogenase E1 and transketolase domain containing 1 -2.38036
RPL18A ribosomal protein L18a -2.31381
ECI2 enoyl-CoA delta isomerase 2 -2.29425
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 -2.29329
TSTD1 thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 -2.26172
KRT14 keratin 14, type I -2.25678
SSNA1 Sjogren syndrome nuclear autoantigen 1 -2.24734
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3 -2.23468
ZBED1 zinc finger, BED-type containing 1 -2.21764
ASMTL acetylserotonin O-methyltransferase-like -2.20052
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) -2.19518
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 -2.19427
PPP1R26 protein phosphatase 1, regulatory subunit 26 -2.19051
POLR2J3 polymerase (RNA) II (DNA directed) polypeptide J3 -2.18562
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit -2.18479
GIMAP4 GTPase, IMAP family member 4 -2.18466
MMP3 matrix metallopeptidase 3 -2.18123
NXN nucleoredoxin -2.17546
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 -2.16051
RPL29 ribosomal protein L29 -2.15862
LYSET lysosomal enzyme trafficking factor -2.15601
TMEM187 transmembrane protein 187 -2.15242
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.1454
HNRNPH2 heterogeneous nuclear ribonucleoprotein H2 (H') -2.12543
CDC42SE1 CDC42 small effector 1 -2.12434
BORCS6 BLOC-1 related complex subunit 6 -2.122
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 -2.10623
EVI2A ecotropic viral integration site 2A -2.10252
SSR4 signal sequence receptor, delta -2.09416
MEPCE methylphosphate capping enzyme -2.07894
PDE2A phosphodiesterase 2A, cGMP-stimulated -2.07364
RPL36A ribosomal protein L36a -2.06942
DCTN6 dynactin 6 -2.05955
AVPI1 arginine vasopressin-induced 1 -2.05786
GATD3 glutamine amidotransferase class 1 domain containing 3 -2.03223
SNPH syntaphilin -2.02999
ZFHX4 zinc finger homeobox 4 -2.02476
RHOC ras homolog family member C -2.00533
PMPCA peptidase (mitochondrial processing) alpha -2.00239