| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 2-amino-5-(5-nitro-2-furyl)-1,3,4-oxadiazole 99.95 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome) |
| Similar Terms | |
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94 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:M13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HMOX1 | heme oxygenase 1 | 9.77417 |
| TXNRD1 | thioredoxin reductase 1 | 7.98885 |
| ABHD4 | abhydrolase domain containing 4 | 4.77757 |
| UGDH | UDP-glucose 6-dehydrogenase | 4.69333 |
| GLRX | glutaredoxin (thioltransferase) | 4.17849 |
| CCL2 | chemokine (C-C motif) ligand 2 | 4.0789 |
| GCLM | glutamate-cysteine ligase, modifier subunit | 3.58524 |
| SSBP2 | single-stranded DNA binding protein 2 | 3.54433 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | 3.39721 |
| SQSTM1 | sequestosome 1 | 3.10075 |
| PEX11A | peroxisomal biogenesis factor 11 alpha | 2.92602 |
| EAPP | E2F-associated phosphoprotein | 2.92377 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 2.82534 |
| TALDO1 | transaldolase 1 | 2.7148 |
| VAV3 | vav 3 guanine nucleotide exchange factor | 2.69599 |
| ALAS1 | 5'-aminolevulinate synthase 1 | 2.64843 |
| CYP4F11 | cytochrome P450, family 4, subfamily F, polypeptide 11 | 2.62042 |
| PRDX1 | peroxiredoxin 1 | 2.6137 |
| CTSL | cathepsin L | 2.55034 |
| TRIM16 | tripartite motif containing 16 | 2.5411 |
| RAB5IF | RAB5 interacting factor | 2.41834 |
| GSR | glutathione reductase | 2.39782 |
| VSIG2 | V-set and immunoglobulin domain containing 2 | 2.39269 |
| KEAP1 | kelch-like ECH-associated protein 1 | 2.36973 |
| CABYR | calcium binding tyrosine-(Y)-phosphorylation regulated | 2.36692 |
| GATAD2A | GATA zinc finger domain containing 2A | 2.34745 |
| UNKL | unkempt family zinc finger-like | 2.2866 |
| ADGRE5 | adhesion G protein-coupled receptor E5 | 2.28046 |
| ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | 2.2329 |
| ACAA1 | acetyl-CoA acyltransferase 1 | 2.2172 |
| KRT18 | keratin 18, type I | 2.19779 |
| ACLY | ATP citrate lyase | 2.18017 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 2.17316 |
| PYCR1 | pyrroline-5-carboxylate reductase 1 | 2.14076 |
| DDX27 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 | 2.13854 |
| RBM28 | RNA binding motif protein 28 | 2.11236 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 2.08659 |
| UBQLN2 | ubiquilin 2 | 2.06585 |
| RAI14 | retinoic acid induced 14 | 2.0617 |
| TRIB3 | tribbles pseudokinase 3 | 2.04282 |
| PEX26 | peroxisomal biogenesis factor 26 | 2.04276 |
| PRR13 | proline rich 13 | 2.02923 |
| TICAM1 | toll-like receptor adaptor molecule 1 | 2.02789 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 2.02094 |
| PHGDH | phosphoglycerate dehydrogenase | 2.01149 |
| OXSR1 | oxidative stress responsive 1 | 2.00706 |
| LOC102724560 | cystathionine beta-synthase | 2.00209 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HOXA5 | homeobox A5 | -5.28634 |
| HMG20B | high mobility group 20B | -4.4399 |
| ANKRD10 | ankyrin repeat domain 10 | -4.07524 |
| CDC20 | cell division cycle 20 | -3.75613 |
| CCNB2 | cyclin B2 | -3.68398 |
| NLRP4 | NLR family, pyrin domain containing 4 | -3.67057 |
| TIMM9 | translocase of inner mitochondrial membrane 9 homolog (yeast) | -3.48501 |
| KIF20A | kinesin family member 20A | -3.48252 |
| PSMB8 | proteasome (prosome, macropain) subunit, beta type, 8 | -3.40768 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | -3.25821 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | -3.08512 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -3.04055 |
| UBE2C | ubiquitin-conjugating enzyme E2C | -3.01739 |
| NUSAP1 | nucleolar and spindle associated protein 1 | -3.00565 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -2.8773 |
| PLK1 | polo-like kinase 1 | -2.69528 |
| CDKN3 | cyclin-dependent kinase inhibitor 3 | -2.65409 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -2.62121 |
| SCYL3 | SCY1-like 3 (S. cerevisiae) | -2.53073 |
| CCDC92 | coiled-coil domain containing 92 | -2.50698 |
| HMMR | hyaluronan-mediated motility receptor (RHAMM) | -2.45951 |
| ACYP2 | acylphosphatase 2, muscle type | -2.44392 |
| STMN1 | stathmin 1 | -2.43347 |
| ZNF318 | zinc finger protein 318 | -2.42979 |
| GRN | granulin | -2.41265 |
| CENPA | centromere protein A | -2.3949 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -2.37936 |
| BIRC5 | baculoviral IAP repeat containing 5 | -2.35303 |
| DECR1 | 2,4-dienoyl CoA reductase 1, mitochondrial | -2.35073 |
| CCNB1 | cyclin B1 | -2.31577 |
| PSME1 | proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) | -2.29837 |
| PPP2R3C | protein phosphatase 2, regulatory subunit B'', gamma | -2.29482 |
| AP5M1 | adaptor-related protein complex 5, mu 1 subunit | -2.26304 |
| DNM1 | dynamin 1 | -2.25713 |
| AURKA | aurora kinase A | -2.24388 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | -2.23226 |
| PLCB3 | phospholipase C, beta 3 (phosphatidylinositol-specific) | -2.19733 |
| WASHC3 | WASH complex subunit 3 | -2.16582 |
| ZNF862 | zinc finger protein 862 | -2.14972 |
| CYTH1 | cytohesin 1 | -2.14829 |
| NPC2 | Niemann-Pick disease, type C2 | -2.12847 |
| CKAP2 | cytoskeleton associated protein 2 | -2.12016 |
| ROBO4 | roundabout, axon guidance receptor, homolog 4 (Drosophila) | -2.0981 |
| KRT14 | keratin 14, type I | -2.06492 |
| HLA-DRB4 | major histocompatibility complex, class II, DR beta 4 | -2.05726 |
| AKAP3 | A kinase (PRKA) anchor protein 3 | -2.03345 |
| COX16 | COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) | -2.01647 |
