CRCGN017_MCF10A.TP53.M_24H:M14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-amino-5-(5-nitro-2-furyl)-1,3,4-oxadiazole 33.32 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

41 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:M14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 7.06182
TXNRD1 thioredoxin reductase 1 4.3761
CXCR4 chemokine (C-X-C motif) receptor 4 3.61844
TBX2 T-box 2 3.46939
WIF1 WNT inhibitory factor 1 3.44106
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 2.99258
OLFML2B olfactomedin-like 2B 2.80608
HMOX1 heme oxygenase 1 2.58122
PRKCQ protein kinase C, theta 2.21052
SATB1 SATB homeobox 1 2.07259

decreased expression

Symbol Name Standardized Value
NPDC1 neural proliferation, differentiation and control, 1 -3.94388
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.77094
PMM2 phosphomannomutase 2 -3.72185
DERA deoxyribose-phosphate aldolase (putative) -3.58985
GOLT1B golgi transport 1B -3.4789
HACD3 3-hydroxyacyl-CoA dehydratase 3 -3.02353
CDC20 cell division cycle 20 -2.93515
KRT14 keratin 14, type I -2.85359
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase -2.67097
RECQL RecQ helicase-like -2.56386
TRAPPC3 trafficking protein particle complex 3 -2.46798
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 -2.45057
RPIA ribose 5-phosphate isomerase A -2.3698
CASD1 CAS1 domain containing 1 -2.28391
PRUNE2 prune homolog 2 (Drosophila) -2.27269
NT5E 5'-nucleotidase, ecto (CD73) -2.23391
VDAC1 voltage-dependent anion channel 1 -2.22328
NINL ninein-like -2.15252
ZNF510 zinc finger protein 510 -2.15144
GOLGA1 golgin A1 -2.14984
ANAPC2 anaphase promoting complex subunit 2 -2.14435
ERC2 ELKS/RAB6-interacting/CAST family member 2 -2.13749
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa -2.11815
MRPS15 mitochondrial ribosomal protein S15 -2.11132
NEUROD1 neuronal differentiation 1 -2.10571
PRPF4 pre-mRNA processing factor 4 -2.07647
SZT2 seizure threshold 2 homolog (mouse) -2.07147
MAOB monoamine oxidase B -2.04363
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 -2.03829
CLCN2 chloride channel, voltage-sensitive 2 -2.02394
CCNG2 cyclin G2 -2.01032