CRCGN017_MCF10A.TP53.M_24H:M15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-amino-5-(5-nitro-2-furyl)-1,3,4-oxadiazole 11.11 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

36 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:M15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RPL39L ribosomal protein L39-like 4.76092
KLHL21 kelch-like family member 21 4.69607
CNRIP1 cannabinoid receptor interacting protein 1 4.55027
MNAT1 MNAT CDK-activating kinase assembly factor 1 4.39123
FGFR4 fibroblast growth factor receptor 4 4.36408
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 4.33122
GATA3 GATA binding protein 3 3.92678
CCL2 chemokine (C-C motif) ligand 2 3.8294
WFS1 Wolfram syndrome 1 (wolframin) 3.73997
ACAA1 acetyl-CoA acyltransferase 1 2.93906
SLC38A6 solute carrier family 38, member 6 2.84164
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.63218
GCC1 GRIP and coiled-coil domain containing 1 2.58209
LYN LYN proto-oncogene, Src family tyrosine kinase 2.49529
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.47089
NDUFB2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa 2.26976
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3 2.2413
CT55 cancer/testis antigen 55 2.21182
MYH8 myosin, heavy chain 8, skeletal muscle, perinatal 2.13937
ANAPC15 anaphase promoting complex subunit 15 2.05163
COBL cordon-bleu WH2 repeat protein 2.04224

decreased expression

Symbol Name Standardized Value
KRT14 keratin 14, type I -4.37423
CD44 CD44 molecule (Indian blood group) -3.98286
RNF167 ring finger protein 167 -3.96918
COG2 component of oligomeric golgi complex 2 -3.95522
CTNND1 catenin (cadherin-associated protein), delta 1 -3.44657
BASP1 brain abundant, membrane attached signal protein 1 -2.87442
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.84689
COTL1 coactosin-like F-actin binding protein 1 -2.57104
IFRD2 interferon-related developmental regulator 2 -2.40332
TSPAN15 tetraspanin 15 -2.24815
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 -2.11382
MSN moesin -2.09727
COPS7B COP9 signalosome subunit 7B -2.05482
NGRN neugrin, neurite outgrowth associated -2.02991
MKS1 Meckel syndrome, type 1 -2.00609