CRCGN017_MCF10A.TP53.M_24H:M20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description penicillin-v-potassium 33.64 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

34 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:M20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAMLD1 mastermind-like domain containing 1 5.03619
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 4.8154
ADO 2-aminoethanethiol (cysteamine) dioxygenase 4.31447
FGFR4 fibroblast growth factor receptor 4 3.41882
GARRE1 granule associated Rac and RHOG effector 1 3.13719
AGR2 anterior gradient 2 3.11033
NRBF2 nuclear receptor binding factor 2 2.57032
GRB10 growth factor receptor-bound protein 10 2.33285
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.31532
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.26019
PDZK1 PDZ domain containing 1 2.25609
GSPT2 G1 to S phase transition 2 2.19196
TRAPPC13 trafficking protein particle complex 13 2.17791
SYNPO2L synaptopodin 2-like 2.11821
CD37 CD37 molecule 2.09059
MTM1 myotubularin 1 2.08605
GFPT2 glutamine-fructose-6-phosphate transaminase 2 2.0211
CHN1 chimerin 1 2.00517

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.5312
GADD45B growth arrest and DNA-damage-inducible, beta -4.31634
TXNDC9 thioredoxin domain containing 9 -4.31406
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.84911
UNC50 unc-50 homolog (C. elegans) -2.51851
CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3 -2.48989
GPBP1L1 GC-rich promoter binding protein 1-like 1 -2.44636
SRP9 signal recognition particle 9kDa -2.38347
TMEM14B transmembrane protein 14B -2.28169
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.26286
TMEM131 transmembrane protein 131 -2.23181
CXCL14 chemokine (C-X-C motif) ligand 14 -2.19049
COX5B cytochrome c oxidase subunit Vb -2.1552
PIH1D1 PIH1 domain containing 1 -2.11528
KCNK1 potassium channel, two pore domain subfamily K, member 1 -2.10353
GBE1 glucan (1,4-alpha-), branching enzyme 1 -2.00201