CRCGN017_MCF10A.TP53.M_24H:M21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description penicillin-v-potassium 11.21 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

40 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:M21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCR4 chemokine (C-X-C motif) receptor 4 5.30598
STIMATE STIM activating enhancer 4.75739
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) 4.75322
TGFB3 transforming growth factor, beta 3 4.71826
CCP110 centriolar coiled coil protein 110kDa 4.63041
HBA1 hemoglobin, alpha 1 4.60163
WFS1 Wolfram syndrome 1 (wolframin) 4.4691
HBB hemoglobin, beta 4.08514
KIF5C kinesin family member 5C 3.97048
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 3.84246
CCDC85B coiled-coil domain containing 85B 3.63033
CADM1 cell adhesion molecule 1 3.07913
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 3.04069
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.99048
FZD7 frizzled class receptor 7 2.827
TMEM177 transmembrane protein 177 2.47644
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.45237
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 2.41662
MRPL4 mitochondrial ribosomal protein L4 2.36384
RAB3A RAB3A, member RAS oncogene family 2.26161
CNN1 calponin 1, basic, smooth muscle 2.23449
RTN1 reticulon 1 2.16448
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) 2.15266
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 2.15195
RPUSD2 RNA pseudouridylate synthase domain containing 2 2.05761
SF3A3 splicing factor 3a, subunit 3, 60kDa 2.04648
IMP4 IMP4, U3 small nucleolar ribonucleoprotein 2.04479
NUBP2 nucleotide binding protein 2 2.02926
COPS7B COP9 signalosome subunit 7B 2.01109

decreased expression

Symbol Name Standardized Value
WASHC4 WASH complex subunit 4 -4.97011
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -4.59519
ANKRD10 ankyrin repeat domain 10 -4.47371
TOMM70 translocase of outer mitochondrial membrane 70 -2.82909
PCCB propionyl CoA carboxylase, beta polypeptide -2.45626
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.24529
CTSL cathepsin L -2.23438
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 -2.19813
KDM3A lysine (K)-specific demethylase 3A -2.14796
JAK1 Janus kinase 1 -2.10343
ANKRD28 ankyrin repeat domain 28 -2.01021